2013
Repeatable Noninvasive Measurement of Mouse Myocardial Glucose Uptake with 18F-FDG: Evaluation of Tracer Kinetics in a Type 1 Diabetes Model
Thorn SL, deKemp RA, Dumouchel T, Klein R, Renaud JM, Wells RG, Gollob MH, Beanlands RS, DaSilva JN. Repeatable Noninvasive Measurement of Mouse Myocardial Glucose Uptake with 18F-FDG: Evaluation of Tracer Kinetics in a Type 1 Diabetes Model. Journal Of Nuclear Medicine 2013, 54: 1637-1644. PMID: 23940301, DOI: 10.2967/jnumed.112.110114.Peer-Reviewed Original ResearchConceptsMyocardial glucose uptakeImage-derived blood input functionAcute insulin treatmentInsulin treatmentBlood activityType 1 diabetic miceType 1 diabetic mouse modelML/min/Glucose uptakeVena cava diameterMyocardial glucose uptake ratesDiabetic mouse modelType 1 diabetesStandardized uptake valueTest-retest repeatabilityAcute insulin stimulationDiabetic miceCoefficient of repeatabilityFDG-PETBland-Altman analysisMyocardial glucoseContrast CTBaseline scanMouse modelTime-activity curvesChronic AMPK activity dysregulation produces myocardial insulin resistance in the human Arg302Gln-PRKAG2 glycogen storage disease mouse model
Thorn SL, Gollob MH, Harper ME, Beanlands RS, deKemp RA, DaSilva JN. Chronic AMPK activity dysregulation produces myocardial insulin resistance in the human Arg302Gln-PRKAG2 glycogen storage disease mouse model. EJNMMI Research 2013, 3: 48. PMID: 23829931, PMCID: PMC3707764, DOI: 10.1186/2191-219x-3-48.Peer-Reviewed Original ResearchMyocardial glucose uptakeCardiac glycogen storesSystolic functionInsulin resistanceAcute insulinMouse modelGlycogen storesDeoxyglucose positron emission tomographyProgressive conduction system diseaseGlucose uptakeSkeletal muscle glucose uptakeExcessive glycogen depositionDisease mouse modelMyocardial insulin resistanceMuscle glucose uptakeConduction system diseaseInsulin receptor expressionPositron emission tomographyPRKAG2 cardiac syndromeFrequent arrhythmiaInsulin stimulationMetabolic therapyReceptor expressionCardiac syndromeSystem diseases
2009
In Vivo Assessment of Myocardial Glucose Uptake by Positron Emission Tomography in Adults With the PRKAG2 Cardiac Syndrome
Ha AC, Renaud JM, deKemp RA, Thorn S, DaSilva J, Garrard L, Yoshinaga K, Abraham A, Green MS, Beanlands RS, Gollob MH. In Vivo Assessment of Myocardial Glucose Uptake by Positron Emission Tomography in Adults With the PRKAG2 Cardiac Syndrome. Circulation Cardiovascular Imaging 2009, 2: 485-491. PMID: 19920047, DOI: 10.1161/circimaging.109.853291.Peer-Reviewed Original ResearchMeSH KeywordsAdultAMP-Activated Protein KinasesCase-Control StudiesEchocardiographyFemaleFluorodeoxyglucose F18Heart DiseasesHumansMaleMetabolic DiseasesMiddle AgedMutationMyocardiumPhenotypeRadiographic Image Interpretation, Computer-AssistedRubidium RadioisotopesStatistics, NonparametricSyndromeTomography, Emission-ComputedConceptsMyocardial glucose uptakeSignificant myocardial scarFDG-PET imagingPRKAG2 cardiac syndromeCardiac syndromeGlucose uptakeAdult patientsMyocardial scarMetabolic diseasesControl groupMedian blood glucoseEuglycemic hyperinsulinemic clampStable blood glucose levelsBlood glucose levelsInherited metabolic diseaseMin/Positron emission tomography (PET) imagingEmission Tomography ImagingPositron emission tomographyMyocardial glucose transportPerfusion scanBlood glucoseControl subjectsHyperinsulinemic clampAffected patients