Change in Brain Magnetic Resonance Spectroscopy after Treatment during Acute HIV Infection
Sailasuta N, Ross W, Ananworanich J, Chalermchai T, DeGruttola V, Lerdlum S, Pothisri M, Busovaca E, Ratto-Kim S, Jagodzinski L, Spudich S, Michael N, Kim JH, Valcour V, Phanuphak N, Teeratakulpisarn N, Fletcher J, Suttichom D, Pinyakorn S, Rattanamanee S, Chomchey N, Mangum P, Ubolyam S, Suwanwela N, Chaisinanunkul N, Suthiponpaisan U, Sutthapas C, deSouza M, Ngauy V, Trichavaroj R, Akapirat S, Marovich M, Wendelken L, Busovaca E, Liu C, Mun E, Miller B. Change in Brain Magnetic Resonance Spectroscopy after Treatment during Acute HIV Infection. PLOS ONE 2012, 7: e49272. PMID: 23229129, PMCID: PMC3500278, DOI: 10.1371/journal.pone.0049272.Peer-Reviewed Original ResearchConceptsOccipital gray matterAntiretroviral therapyHIV infectionFrontal gray matterFrontal white matterN-acetyl aspartateBasal gangliaControl subjectsGray matterHIV-negative control subjectsInitiation of ARTSingle-voxel proton magnetic resonance spectroscopyBrain magnetic resonance spectroscopyAcute HIV infectionEarly antiretroviral therapyBrain metabolite levelsNegative control subjectsProton magnetic resonance spectroscopyMagnetic resonance spectroscopyHIV subjectsBrain inflammationNeuronal injuryHIV casesCNS injuryCellular inflammation
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