2012
The cerebrospinal fluid proteome in HIV infection: change associated with disease severity
Angel TE, Jacobs JM, Spudich SS, Gritsenko MA, Fuchs D, Liegler T, Zetterberg H, Camp DG, Price RW, Smith RD. The cerebrospinal fluid proteome in HIV infection: change associated with disease severity. Clinical Proteomics 2012, 9: 3. PMID: 22433316, PMCID: PMC3353874, DOI: 10.1186/1559-0275-9-3.Peer-Reviewed Original ResearchCNS HIV infectionHIV infectionCerebrospinal fluidChronic asymptomatic infectionSystemic HIV infectionNervous system infectionAmyloid precursor proteinCSF proteomic analysisCerebrospinal fluid proteomeCSF neopterinAntiretroviral therapyDifferent time pointsSystem infectionNeural injuryImmune activationMotor dysfunctionAsymptomatic infectionClinical spectrumCSF biomarkersCSF analysisDisease progressionCSF samplesNeuronal plasticityDisease severityInfection
2008
Antiretroviral Therapy and Central Nervous System HIV Type 1 Infection
Price RW, Spudich S. Antiretroviral Therapy and Central Nervous System HIV Type 1 Infection. The Journal Of Infectious Diseases 2008, 197: s294-s306. PMID: 18447615, PMCID: PMC2628635, DOI: 10.1086/533419.Peer-Reviewed Original ResearchConceptsCNS HIV-1 infectionAntiretroviral therapyHIV-1 infectionType 1 infectionCerebrospinal fluidHuman immunodeficiency virus type 1 (HIV-1) infectionSystemic infectionHIV Type 1 InfectionImmunodeficiency syndrome dementia complexVirus type 1 infectionUntreated systemic infectionCombination antiretroviral therapyCNS opportunistic infectionsMinority of patientsEarly treatment interventionLocal inflammatory reactionPrimary viremiaNeurological progressionOpportunistic infectionsDementia complexAsymptomatic infectionSilent infectionBrain injuryInflammatory reactionHIV-1