2024
Unveiling the Structure in Mental Disorder Presentations
Spiller T, Duek O, Helmer M, Murray J, Fielstein E, Pietrzak R, von Känel R, Harpaz-Rotem I. Unveiling the Structure in Mental Disorder Presentations. JAMA Psychiatry 2024, 81: 1101-1107. PMID: 39110437, PMCID: PMC11307158, DOI: 10.1001/jamapsychiatry.2024.2047.Peer-Reviewed Original ResearchSymptom combinationsNational Institute of Mental Health Data ArchivePosttraumatic stress disorderDiagnostic criteriaHeterogeneity of symptomsSecondary data analysisCross-sectional studyRevision of diagnostic criteriaSymptom-based definitionsDSM criteriaStress disorderSymptom heterogeneityDisorder presentationsClinical populationsMain OutcomesAssess symptomsGroup of individualsParticipantsSymptomsNational InstituteDisordersIndividualsSchizophreniaAnxietyIndividual frequenciesPosttraumatic Stress Disorder, Obesity, and Accelerated Epigenetic Aging Among US Military Veterans
Fischer I, Na P, Nagamatsu S, Jeste D, Cabrera-Mendoza B, Montalvo-Ortiz J, Krystal J, Polimanti R, Gelernter J, Pietrzak R. Posttraumatic Stress Disorder, Obesity, and Accelerated Epigenetic Aging Among US Military Veterans. JAMA Psychiatry 2024, 81 PMID: 39476130, DOI: 10.1001/jamapsychiatry.2024.3403.Peer-Reviewed Original ResearchPrevalence, Correlates, and Burden of Subthreshold PTSD in US Veterans.
Fischer I, Na P, Harpaz-Rotem I, Marx B, Pietrzak R. Prevalence, Correlates, and Burden of Subthreshold PTSD in US Veterans. The Journal Of Clinical Psychiatry 2024, 85 PMID: 39480145, DOI: 10.4088/jcp.24m15465.Peer-Reviewed Original ResearchConceptsSubthreshold posttraumatic stress disorderPosttraumatic stress disorderPosttraumatic stress disorder symptom clustersLifetime psychiatric disordersUS veteransUS military veteransSymptom-related distressStress disorderPsychiatric disordersSymptom clustersTreating veteransCriterion AMilitary veteransTraumatic eventsCognitive functionWorking case definitionMental healthCriterion FFunctional impairmentVeteransNationally representative sampleFunctional correlatesDisordersElevated oddsGreater oddsThe association of perceived social support, resilience, and posttraumatic stress symptoms among coronavirus disease patients in the United States
Li J, Wisnivesky J, Gonzalez A, Feder A, Pietrzak R, Chanumolu D, Hu L, Kale M. The association of perceived social support, resilience, and posttraumatic stress symptoms among coronavirus disease patients in the United States. Journal Of Affective Disorders 2024, 368: 390-397. PMID: 39293600, DOI: 10.1016/j.jad.2024.09.091.Peer-Reviewed Original ResearchCOVID-19-related posttraumatic stress disorderPosttraumatic stress disorderPre-existing mental disordersSocial supportMental disordersPosttraumatic Stress Disorder ChecklistPosttraumatic stress disorder symptomsRisk of posttraumatic stress disorderCD-RISCPosttraumatic stress symptomsAcute careAssociation of perceived social supportMedical Outcomes Study Social Support SurveyTargeting of preventive interventionsConnor-Davidson Resilience ScalePsychological consequences of COVID-19Low social supportSocial Support SurveyMeasures of resilienceDSM-5Associated with lower oddsStress disorderStress symptomsCross-sectional designPsychological resilienceAmygdala Cannabinoid 1 Receptor, Pain Response, and Emotional Numbing in Trauma-Exposed Individuals
Korem N, Hillmer A, D’Souza D, Nia A, Levy I, Pietrzak R, Harpaz-Rotem I. Amygdala Cannabinoid 1 Receptor, Pain Response, and Emotional Numbing in Trauma-Exposed Individuals. JAMA Network Open 2024, 7: e2432387. PMID: 39250156, PMCID: PMC11385051, DOI: 10.1001/jamanetworkopen.2024.32387.Peer-Reviewed Original ResearchMicroglia-mediated neuroimmune suppression in PTSD is associated with anhedonia
Bonomi R, Hillmer A, Woodcock E, Bhatt S, Rusowicz A, Angarita G, Carson R, Davis M, Esterlis I, Nabulsi N, Huang Y, Krystal J, Pietrzak R, Cosgrove K. Microglia-mediated neuroimmune suppression in PTSD is associated with anhedonia. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2406005121. PMID: 39172786, PMCID: PMC11363315, DOI: 10.1073/pnas.2406005121.Peer-Reviewed Original ResearchConceptsPTSD groupPrefrontal-limbic circuitsNeuroimmune responseAssociated with anhedoniaPosttraumatic stress disorderPositron emission tomography brain imagingTranslocator protein availabilityBrain immune functionAnhedonic symptomsStress disorderPeripheral immune dysfunctionPTSDGroup differencesSeverity of symptomsPsychiatric diseasesTranslocator proteinBrain imagingAdministration of lipopolysaccharideSymptomsMicroglial markersLPS-induced increaseCompared to controlsImmune functionSickness symptomsAnhedoniaSuccessful Aging in US Veterans with Mental Disorders: Results From the National Health and Resilience in Veterans Study
Shin J, Fischer I, Na P, Jeste D, Pietrzak R. Successful Aging in US Veterans with Mental Disorders: Results From the National Health and Resilience in Veterans Study. American Journal Of Geriatric Psychiatry 2024 PMID: 39214753, DOI: 10.1016/j.jagp.2024.07.018.Peer-Reviewed Original ResearchGeneralized anxiety disorderPosttraumatic stress disorderMental disordersSomatic symptomsNational Health and ResilienceUS military veteransSuccessful agingAnxiety disordersDepressive disorderUS veteransStress disorderPromote successful agingHigher gratitudeVeterans StudyMilitary veteransInterventions targeting psychosocial factorsOne-in-fiveVeteransMDDDisordersPsychosocial factorsGratitudeNegative associationSymptomsMultivariate logistic regressionMental Health Apps and U.S. Military Veterans: Perceived Importance and Utilization of the National Center for Posttraumatic Stress Disorder App Portfolio
Jaworski B, Ramsey K, Taylor K, Heinz A, Senti S, Mackintosh M, Rosen C, Owen J, Pietrzak R. Mental Health Apps and U.S. Military Veterans: Perceived Importance and Utilization of the National Center for Posttraumatic Stress Disorder App Portfolio. Psychological Services 2024, 21: 538-551. PMID: 37917475, DOI: 10.1037/ser0000806.Peer-Reviewed Original ResearchMental health appsPosttraumatic stress disorderU.S. veteransHealth appsStress disorderVeterans Affairs (VA) National CenterMental health treatmentLower household incomeMore mental health concernsSelf-management appMental health concernsU.S. military veteransNeeds of veteransMedical conditionsGeneral populationVeteran populationHealth treatmentWhite veteransHealth concernConsistent associationVariety of barriersHealth careMilitary veteransBlack veteransVeteransUnraveling PTSD: Symptom Cluster Change During and 1 Year After Veterans’ Residential PTSD Treatment
Gross G, Spiller T, Ben-Zion Z, Rubenstein A, Pietrzak R, Duek O, Hoff R, Harpaz-Rotem I. Unraveling PTSD: Symptom Cluster Change During and 1 Year After Veterans’ Residential PTSD Treatment. Psychological Trauma Theory Research Practice And Policy 2024 PMID: 38990694, DOI: 10.1037/tra0001734.Peer-Reviewed Original ResearchPosttraumatic stress disorderPosttraumatic stress disorder symptom clustersPosttraumatic stress disorder clustersSymptom clustersIntrusive symptomsResidential treatmentTreatment of posttraumatic stress disorderPosttraumatic stress disorder symptomsResidential PTSD treatmentPTSD symptom clustersNovel treatment interventionsDifferential treatment responseReduce symptom severityDifferential patterns of changeAvoidance symptomsPTSD treatmentTreatment gainsStress disorderVeterans AffairsSymptom severityCluster CTreatment interventionsCluster BIndividual symptomsCohort of veteransW35 Nicotine Use and Metabotropic Glutamate Receptor 5 (mGluR5) in Individuals With Major Depressive and Post Traumatic Stress Disorders
Baldassarri S, Asch R, Hillmer A, Pietrzak R, DellaGioia N, Esterlis I, Davis M. W35 Nicotine Use and Metabotropic Glutamate Receptor 5 (mGluR5) in Individuals With Major Depressive and Post Traumatic Stress Disorders. Drug And Alcohol Dependence 2024, 260: 110653. DOI: 10.1016/j.drugalcdep.2023.110653.Peer-Reviewed Original ResearchMaladaptive health factors as potential mediators for the association between posttraumatic stress disorder and cardiovascular disease: A sex-stratified analysis in the U.S. adult population
Pierce S, Reynolds K, Sommer J, El-Gabalawy R, Pietrzak R, Sumner J, Mota N. Maladaptive health factors as potential mediators for the association between posttraumatic stress disorder and cardiovascular disease: A sex-stratified analysis in the U.S. adult population. Journal Of Psychiatric Research 2024, 177: 102-108. PMID: 39002531, DOI: 10.1016/j.jpsychires.2024.06.028.Peer-Reviewed Original ResearchHealth risk factorsPosttraumatic stress disorderRisk factorsPotential mediatorsCardiovascular diseaseLow physical activityCross-sectional surveyNatural effect modelsSex-stratified analysesU.S. adult populationCardiovascular disease riskStress disorderPhysical activityNational Epidemiologic SurveyLogistic regression analysisHealth factorsEvaluate health risk factorsU.S. adultsHigher BMICausal pathwaysPrevention strategiesEffects of posttraumatic stress disorderWave 3Adult populationSubstance usePosttraumatic stress disorder and insomnia in US military veterans: Prevalence, correlates, and psychiatric and functional burden
Georgescu M, Fischer I, Beydoun M, McCarthy E, DeViva J, Pietrzak R. Posttraumatic stress disorder and insomnia in US military veterans: Prevalence, correlates, and psychiatric and functional burden. Journal Of Sleep Research 2024, e14269. PMID: 38845413, DOI: 10.1111/jsr.14269.Peer-Reviewed Original ResearchPosttraumatic stress disorderStress disorderMilitary veteransInsomnia groupCo-occurring posttraumatic stress disorderBurden of PTSDTreating posttraumatic stress disorderClinical management of insomniaRates of psychiatric conditionsGeneralized anxiety disorderCurrent suicidal ideationMitigate suicide riskUS veteransManagement of insomniaUS military veteransMental health burdenFunctional burdenAnxiety disordersDepressive disorderSuicidal ideationSuicide riskPsychiatric conditionsPsychosocial functioningSocial functioningInsomniaHelping the Helpers: Mental Health Challenges of Psychosocial Support Workers During the Russian-Ukrainian War
Kang H, Fischer I, Esterlis I, Kolyshkina A, Ponomarenko L, Chobanian A, Vus V, Pietrzak R. Helping the Helpers: Mental Health Challenges of Psychosocial Support Workers During the Russian-Ukrainian War. Disaster Medicine And Public Health Preparedness 2024, 18: e95. PMID: 38829179, DOI: 10.1017/dmp.2024.68.Peer-Reviewed Original ResearchConceptsPsychosocial support workersPosttraumatic stress disorderAssociated with greater oddsPresence of meaning in lifeMeaning in lifeSuicidal ideationMental health challengesGreater oddsMental healthLow optimismSupport workersHealth challengesMental health problemsCorrelates of burnoutPromote social connectednessStress disorderPsychosocial characteristicsGreater distressWar exposureGeneral populationHealth problemsSocial connectednessBurnoutOddsSocial relationshipsFunctional significance of posttraumatic growth in U.S. military veterans
Gower T, Fischer I, Tsai J, Kang H, Na P, Tedeschi R, Pietrzak R. Functional significance of posttraumatic growth in U.S. military veterans. Journal Of Affective Disorders 2024, 356: 267-273. PMID: 38614442, DOI: 10.1016/j.jad.2024.04.046.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderPosttraumatic stress disorder symptomsPosttraumatic growthPsychosocial functioningTraumatic eventsTrauma-exposed U.S. veteransNational Health and ResilienceMale veteran samplePost-trauma functioningPattern of findingsRetrospective self-reportsU.S. military veteransVeteran sampleStress disorderVeterans StudyExamined relationsCross-sectional designMilitary veteransNationally representative sampleU.S. veteransAssociated with functionsPhysical functionClinical interventionsPsychosocial characteristicsVeteransRandomized controlled trial of two internet-based written therapies for world trade center workers and survivors with persistent PTSD symptoms
Feder A, Kowalchyk M, Brinkman H, Cahn L, Aaronson C, Böttche M, Presseau C, Fred-Torres S, Markowitz J, Litz B, Yehuda R, Knaevelsrud C, Pietrzak R. Randomized controlled trial of two internet-based written therapies for world trade center workers and survivors with persistent PTSD symptoms. Psychiatry Research 2024, 336: 115885. PMID: 38603979, DOI: 10.1016/j.psychres.2024.115885.Peer-Reviewed Original ResearchPosttraumatic stress disorderPosttraumatic stress disorder symptom clustersWTC-related PTSD symptomsMental health-related functioningPTSD symptomsSymptom clustersHealth-related functioningPosttraumatic stress disorder's avoidancePosttraumatic stress disorder symptomsPosttraumatic Stress Disorder ChecklistPresent-centered therapyAssociated with significantly greater reductionsPersistent PTSD symptomsActive control interventionModerate-to-largeQuality of lifeSignificant main effectTreatment-by-time interactionWorld Trade Center survivorDSM-5PCL-5Stress disorderDepressive/anxiety symptomsWorld Trade CenterDepressive symptomsObesity in Latinx and White U.S. military veterans: Mental health, psychosocial burden, non-suicidal self-injury and suicidal behavior
Stefanovics E, Grilo C, Potenza M, Pietrzak R. Obesity in Latinx and White U.S. military veterans: Mental health, psychosocial burden, non-suicidal self-injury and suicidal behavior. Psychiatry Research 2024, 335: 115844. PMID: 38484606, DOI: 10.1016/j.psychres.2024.115844.Peer-Reviewed Original ResearchNon-suicidal self-injuryDrug use disordersU.S. military veteransMental health problemsMilitary veteransSelf-injuryUse disorderSymptoms of internalizing disordersLevels of childhood traumaNational Health and ResiliencePost-traumatic stress disorderIncreased risk of mental health problemsWhite veteransCoping self-efficacyRisk of mental health problemsLatinx ethnicityGeneralized anxietyStress disorderChildhood traumaHealth problemsSuicidal behaviorVeterans StudyCorrelates of obesityCulturally sensitive preventionNationally representative sampleDifferential associations of adverse childhood experiences and mental health outcomes in U.S. military veterans
Slavin A, Fischer I, Pietrzak R. Differential associations of adverse childhood experiences and mental health outcomes in U.S. military veterans. Journal Of Psychiatric Research 2024, 172: 261-265. PMID: 38412789, DOI: 10.1016/j.jpsychires.2024.02.040.Peer-Reviewed Original ResearchConceptsAdverse childhood experiencesMental health outcomesChildhood traumaEmotional neglectMilitary veteransChildhood experiencesNational Health and ResiliencePrevalence of childhood traumaAssociated with adverse mental health outcomesHealth outcomesChildhood emotional neglectPosttraumatic stress disorderEffects of adverse childhood experiencesU.S. military veteransAssociation of adverse childhood experiencesSample of veteransAdverse mental health outcomesAdverse mental health effectsStress disorderGeneralized anxietyPopulation-based sample of veteransVeterans StudySuicidal thoughtsPopulation-based sampleIndividual adverse childhood experiences
2023
Clinical significance of novel 8-factor model of DSM-5 PTSD in national VA PTSD residential treatment data: Internally- v. externally-cued intrusions
Gross G, Spiller T, Duek O, Pietrzak R, Harpaz-Rotem I. Clinical significance of novel 8-factor model of DSM-5 PTSD in national VA PTSD residential treatment data: Internally- v. externally-cued intrusions. Journal Of Affective Disorders 2023, 328: 255-260. PMID: 36806596, DOI: 10.1016/j.jad.2023.02.046.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderPTSD symptomsDysphoric arousalDSM-5 posttraumatic stress disorderDSM-5 PTSD symptomsDistinct underlying processesSelf-report measuresGeneralized anxiety symptomsSuperior model fitPhysical health functioningCore defining featuresStructural equation modelingWorse emotional functioningAnxious arousalSymptoms of depressionNegative affectIntrusion symptomsGreater avoidanceEmotional functioningStress disorderAnxiety symptomsPTSD ChecklistIntrusion factorCross-sectional designGeneralized anxietyInteractive association of posttraumatic stress disorder, apolipoprotein ε4 genotype, and age on cognitive functioning
Lawrence K, Rippey C, Welikson B, Pietrzak R, Adams T. Interactive association of posttraumatic stress disorder, apolipoprotein ε4 genotype, and age on cognitive functioning. International Journal Of Geriatric Psychiatry 2023, 38: e5888. PMID: 36757293, PMCID: PMC10168127, DOI: 10.1002/gps.5888.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderThree-way interactionCognitive functioningStress disorderOlder participantsTreatment of PTSDMain effectProbable posttraumatic stress disorderAge-related cognitive impairmentAPOE ε4U.S. military veteransApolipoprotein ε4 genotypeCognitive deficitsPsychomotor performanceAge-related associationsInteractive associationsVeterans StudyMilitary veteransCognitive impairmentPreliminary evidenceTwo-way interactionAPM performanceΕ4 carriersAnalysis of covarianceFunctioningSubjective cognitive difficulties and posttraumatic stress disorder interact to increase suicide risk among middle-aged and older US military veterans
Cations M, Cook J, Nichter B, Esterlis I, Pietrzak R. Subjective cognitive difficulties and posttraumatic stress disorder interact to increase suicide risk among middle-aged and older US military veterans. International Psychogeriatrics 2023, 36: 599-607. PMID: 36756753, DOI: 10.1017/s1041610222001053.Peer-Reviewed Original ResearchPosttraumatic stress disorderSubjective cognitive difficultiesCurrent suicidal intentSuicidal intentSuicidal ideationPatient Health Questionnaire-9Suicide riskStress disorderCurrent posttraumatic stress disorderMilitary veteransCross-sectional studyUnited States military veteransUS military veteransCognitive Functioning ScaleOlder U.S. veteransCognitive difficultiesSubjective cognitive impairmentQuestionnaire-9US veteransNational HealthSuicide Behaviors QuestionnaireOlder veteransCognitive impairmentConcentration difficultiesU.S. veterans