2016
Calcium and 1,25-dihydroxyvitamin D3 modulate genes of immune and inflammatory pathways in the human colon: a human crossover trial 1–3
Protiva P, Pendyala S, Nelson C, Augenlicht LH, Lipkin M, Holt PR. Calcium and 1,25-dihydroxyvitamin D3 modulate genes of immune and inflammatory pathways in the human colon: a human crossover trial 1–3. American Journal Of Clinical Nutrition 2016, 103: 1224-1231. PMID: 27009752, PMCID: PMC4841933, DOI: 10.3945/ajcn.114.105304.Peer-Reviewed Original ResearchConceptsWestern-style dietCalcium supplementationInflammatory pathwaysImmune responseHuman colorectumAdequate vitamin D statusHigh dietary calcium intakeLower colorectal cancer riskClinical trial evidenceDietary calcium intakePrimary study endpointVitamin D statusColorectal cancer riskUrinary calcium concentrationD statusCalcium intakeUrinary calciumStudy endpointCrossover trialTrial evidenceBiopsy specimensColorectal mucosaTrial protocolColonic mucosaAdaptive immunity
2008
Growth inhibition of colon cancer cells by polyisoprenylated benzophenones is associated with induction of the endoplasmic reticulum response
Protiva P, Hopkins ME, Baggett S, Yang H, Lipkin M, Holt PR, Kennelly EJ, Bernard WI. Growth inhibition of colon cancer cells by polyisoprenylated benzophenones is associated with induction of the endoplasmic reticulum response. International Journal Of Cancer 2008, 123: 687-694. PMID: 18470880, DOI: 10.1002/ijc.23515.Peer-Reviewed Original ResearchMeSH KeywordsActivating Transcription Factor 4ApoptosisBenzophenonesCaspasesCell CycleCell Line, TumorCell SurvivalColonic NeoplasmsDNA-Binding ProteinsEndoplasmic ReticulumGarciniaGene Expression Regulation, NeoplasticHCT116 CellsHT29 CellsHumansInhibitory Concentration 50Linear ModelsMitochondrial MembranesNuclear ProteinsPrenylationProtein KinasesReactive Oxygen SpeciesRegulatory Factor X Transcription FactorsSignal TransductionTOR Serine-Threonine KinasesTranscription Factor CHOPTranscription FactorsUp-RegulationX-Box Binding Protein 1ConceptsEndoplasmic reticulum stress responseMitochondrial membrane potentialColon cancer cellsReticulum stress responseCaspase activationGene expressionStress responseSurvival pathwaysDDIT3/CHOPGuttiferone EEndoplasmic reticulum responseHuman colon cancer cellsParallel molecular pathwaysCell survival pathwaysCancer cellsCell linesMembrane potentialColon cancer cell linesHuman colon cancer cell linesREDD1 geneGene arrayMTOR survival pathwayCell cycleMolecular pathwaysCancer cell lines