2012
Dietary Methyl Donor Depletion Protects Against Intestinal Tumorigenesis in ApcMin/+ Mice
Kadaveru K, Protiva P, Greenspan EJ, Kim YI, Rosenberg DW. Dietary Methyl Donor Depletion Protects Against Intestinal Tumorigenesis in ApcMin/+ Mice. Cancer Prevention Research 2012, 5: 911-920. PMID: 22677908, PMCID: PMC3397832, DOI: 10.1158/1940-6207.capr-11-0544.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiomarkers, TumorCaloric RestrictionDietFolic AcidFolic Acid DeficiencyGene Expression ProfilingGenes, APCHumansIntestinal NeoplasmsMiceMice, Inbred C57BLOligonucleotide Array Sequence AnalysisReal-Time Polymerase Chain ReactionReverse Transcriptase Polymerase Chain ReactionRNA, MessengerSignal TransductionConceptsWeeks of ageIntestinal tumorigenesisCancer protectionNormal-appearing colonic mucosaMethyl donor statusSmall intestinal tumorsHigh-risk populationDietary folate supplementationVitamin B12 depletionColon cancer riskIntestinal tumor formationBody weight gainMD miceTumor numberTumor sizeMDS groupIntestinal tumorsColonic mucosaFolate supplementationProtective effectB12 depletionInflammatory signalingCancer riskDeficient dietFolate deficiency
2011
Chemoprevention
Singerman J, Protiva P. Chemoprevention. Clinical Gastroenterology 2011, 187-200. DOI: 10.1007/978-1-60761-398-5_12.Peer-Reviewed Original ResearchColorectal cancerCancer-related death rateColorectal cancer riskCommon malignancyLynch syndromeCancer preventionFamily historyCancer killerCancer riskNutritional statusNew casesCancerDeath rateEnvironmental exposuresPharmaceutical agentsHeritable disorderRiskUnited StatesMost casesChemoprophylaxisChemopreventionHNPCCMalignancySyndromeAgents