Under-reporting and Poor Adherence to Monitoring Guidelines for Severe Cases of Isoniazid Hepatotoxicity
Hayashi P, Fontana R, Chalasani N, Stolz A, Talwalkar J, Navarro V, Lee W, Davern T, Kleiner D, Gu J, Hoofnagle J, Investigators D, Chalasani N, Vuppalanchi R, Molleston J, Lumeng L, Corne A, Plummer A, Bonkovsky H, Protiva P, Freston J, Rosson R, Levine R, Maliakkal B, Appleton P, Smialek M, Fontana R, Conjeevaram H, Moseley R, Gordon S, Welch S, Worley J, Kridler J, Trivedi S, Kochlar S, Watkins P, Hayashi P, Russo M, Guess H, Beaver K, Smith A, Lewis J, Pusek S, Russell T, Mehltretter L, Davern T, Bonacini M, Partovi K, Fajardo K, Tai S, Lee W, Rockey D, Larson A, Grant L, Landgraf K, Stoltz A, Kaplowitz N, Milstein S, Talwalker J, Johnson S, Navarro V, Reddy R, Vega M, Wirjosemito A, Evans K, Rochon J, McHutchison J, Tilllmann H, Maggio M, Yang H, Galan K, Cosslin E, Sunas L, Collini M, Rose T, Crowder M, Scharenbroich C, Rostami H, Jiezhun S, Monroe T, Hammett A, Rosado N, Serrano J, Seeff L, Hoofnagle J, Toke D, Witt D, Higgins H, Kleiner D, Avigan M, Senior J. Under-reporting and Poor Adherence to Monitoring Guidelines for Severe Cases of Isoniazid Hepatotoxicity. Clinical Gastroenterology And Hepatology 2015, 13: 1676-1682.e1. PMID: 25724701, PMCID: PMC4653068, DOI: 10.1016/j.cgh.2015.02.024.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAdverse Drug Reaction Reporting SystemsAgedAntitubercular AgentsChemical and Drug Induced Liver InjuryChildChild, PreschoolDrug-Related Side Effects and Adverse ReactionsFemaleGuideline AdherenceHealth Services ResearchHumansIsoniazidMaleMiddle AgedProspective StudiesRetrospective StudiesUnited StatesYoung AdultConceptsLiver transplantationATS guidelinesIsoniazid hepatotoxicityLeading causeATS criteriaMeeting criteriaAmerican Thoracic Society guidelinesUnderwent liver transplantationThoracic Society guidelinesSeverity Index scoreCases of hepatotoxicityLatent tuberculosisMedian ageLiver injurySociety guidelinesPoor adherenceSevere outcomesInclusion criteriaSevere casesSevere injuriesIndex scoreHepatotoxicityAbstractTextMonitoring guidelinesPatients
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