Lack of GPR88 enhances medium spiny neuron activity and alters motor- and cue-dependent behaviors
Quintana A, Sanz E, Wang W, Storey GP, Güler AD, Wanat MJ, Roller BA, La Torre A, Amieux PS, McKnight GS, Bamford NS, Palmiter RD. Lack of GPR88 enhances medium spiny neuron activity and alters motor- and cue-dependent behaviors. Nature Neuroscience 2012, 15: 1547-1555. PMID: 23064379, PMCID: PMC3483418, DOI: 10.1038/nn.3239.Peer-Reviewed Original ResearchMeSH KeywordsAnalysis of VarianceAnimalsAvoidance LearningBenzylaminesBiophysicsCells, CulturedChromonesCorpus StriatumCuesElectric StimulationEmbryo, MammalianExcitatory Amino Acid AntagonistsExcitatory Postsynaptic PotentialsFemaleGABA AntagonistsGamma-Aminobutyric AcidGene Expression ProfilingGreen Fluorescent ProteinsIn Vitro TechniquesMaleMaze LearningMiceMice, Inbred C57BLMice, TransgenicMotor ActivityMutationNeuronsOligonucleotide Array Sequence AnalysisPhosphinic AcidsReceptors, AMPAReceptors, GABA-BReceptors, G-Protein-CoupledRotarod Performance TestConceptsMedium spiny neuronsMedium spiny neuron activityStriatal medium spiny neuronsOrphan G protein-coupled receptorPoor motor coordinationG protein-coupled receptorsProtein-coupled receptorsSpiny neuronsMotor coordinationGPR88Neuron activityFiring rateReduced inhibitionHyperactivityMiceNeuronsReceptorsRegulation of prefrontal excitatory neurotransmission by dopamine in the nucleus accumbens core
Wang W, Dever D, Lowe J, Storey GP, Bhansali A, Eck EK, Nitulescu I, Weimer J, Bamford NS. Regulation of prefrontal excitatory neurotransmission by dopamine in the nucleus accumbens core. The Journal Of Physiology 2012, 590: 3743-3769. PMID: 22586226, PMCID: PMC3476631, DOI: 10.1113/jphysiol.2012.235200.Peer-Reviewed Original ResearchMeSH KeywordsAdenosineAmphetamineAnimalsDopamineEndocannabinoidsGreen Fluorescent ProteinsMaleMiceMice, TransgenicNucleus AccumbensOptical ImagingPrefrontal CortexPresynaptic TerminalsPyridinium CompoundsQuaternary Ammonium CompoundsReceptors, AMPAReceptors, Dopamine D1Receptors, GlutamateReceptors, N-Methyl-D-AspartateSynaptic TransmissionConceptsD2 receptor-expressing cellsReceptor-expressing cellsMedium spiny neuronsSpiny neuronsExcitatory inputsD2 receptor-expressing medium spiny neuronsReceptor-expressing medium spiny neuronsGroup 1 metabotropic glutamate receptorsActivation of NMDAReceptor null miceMetabotropic glutamate receptorsBacterial artificial chromosome transgenic miceDopamine D1 receptorsBasal ganglia pathwaysConvergence of excitatoryNucleus accumbens coreCortical terminalsGlutamate releaseGlutamatergic inputsStriatonigral pathwayInhibitory modulationGlutamatergic signalsD1 receptorsSlice preparationGlutamatergic synapses