2019
Dopamine Deficiency Reduces Striatal Cholinergic Interneuron Function in Models of Parkinson’s Disease
McKinley JW, Shi Z, Kawikova I, Hur M, Bamford IJ, Sudarsana Devi SP, Vahedipour A, Darvas M, Bamford NS. Dopamine Deficiency Reduces Striatal Cholinergic Interneuron Function in Models of Parkinson’s Disease. Neuron 2019, 103: 1056-1072.e6. PMID: 31324539, PMCID: PMC7102938, DOI: 10.1016/j.neuron.2019.06.013.Peer-Reviewed Original ResearchMeSH KeywordsAcetylcholineAmphetamineAnimalsCholinergic NeuronsCyclic AMP-Dependent Protein KinasesDisease Models, AnimalDopamineDopamine AgentsDopamine Plasma Membrane Transport ProteinsHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsInterneuronsMiceNeostriatumParkinson DiseasePatch-Clamp TechniquesReceptors, Dopamine D1Receptors, Dopamine D2Transcription, GeneticConceptsParkinson's diseaseDA deficiencyACh availabilityD1-type DA receptorsHyperpolarization-activated cation channelsRelease of acetylcholineStriatal acetylcholineDA receptorsStriatal interneuronsMotor deficitsDopamine deficiencyDA releasePharmacological treatmentResidual axonsStriatal synapsesMotor functionInterneuron functionAcetylcholineCognitive functionHCN channelsDiseaseCation channelsDopamineSpike timingDeficiency
2015
Dopamine-dependent corticostriatal synaptic filtering regulates sensorimotor behavior
Wong MY, Borgkvist A, Choi SJ, Mosharov EV, Bamford NS, Sulzer D. Dopamine-dependent corticostriatal synaptic filtering regulates sensorimotor behavior. Neuroscience 2015, 290: 594-607. PMID: 25637802, PMCID: PMC4494866, DOI: 10.1016/j.neuroscience.2015.01.022.Peer-Reviewed Original ResearchConceptsReceptor agonistD2-like receptor agonistDopamine D2-like receptor agonistsSensorimotor responsesNigrostriatal dopamine axonsD2 receptor activationD2 receptor agonistCB1 receptor antagonistLeft dorsal striatumSensorimotor behaviorSynaptic filteringCB1 endocannabinoid receptorLesioned miceCorticostriatal terminalsCorticostriatal synapsesSensorimotor deficitsReplacement therapyD2 agonistMetabotropic glutamateReceptor antagonistCB1 receptorsEndocannabinoid receptorsSynaptic activityControl disordersCorticostriatal activity
2012
Overinhibition of corticostriatal activity following prenatal cocaine exposure
Wang W, Nitulescu I, Lewis JS, Lemos JC, Bamford IJ, Posielski NM, Storey GP, Phillips PE, Bamford NS. Overinhibition of corticostriatal activity following prenatal cocaine exposure. Annals Of Neurology 2012, 73: 355-369. PMID: 23225132, PMCID: PMC3766752, DOI: 10.1002/ana.23805.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAnalysis of VarianceAnesthetics, LocalAnimalsBiophysicsCerebral CortexCocaineCorpus StriatumDopamineDopamine AgentsDopamine Uptake InhibitorsDrug InteractionsElectric StimulationEmbryo, MammalianExcitatory Amino Acid AntagonistsExcitatory Postsynaptic PotentialsExploratory BehaviorFemaleGABA AgentsGreen Fluorescent ProteinsHindlimb SuspensionIn Vitro TechniquesInterneuronsLidocaineMaleMiceMice, Inbred C57BLMice, TransgenicNerve Tissue ProteinsNeural InhibitionNeuronal PlasticityPatch-Clamp TechniquesPregnancyPrenatal Exposure Delayed EffectsQuinoxalinesQuinpiroleReceptors, GABA-ARotarod Performance TestSodium Channel BlockersStatistics, NonparametricTetrodotoxinConceptsPrenatal cocaine exposureCocaine exposureCorticostriatal activityTonic GABA currentsGABAA receptor antagonistBasal ganglia functionDopamine-dependent behaviorsCorticostriatal terminalsGABA interneuronsCorticostriatal synapsesDopamine-dependent plasticityGABAergic mechanismsGlutamate releaseGABAB receptorsMotor abnormalitiesGanglia functionTonic inhibitionReceptor antagonistStriatal synapsesAdolescent miceGABAergic signalingGABA currentsClinical studiesD2 receptorsPolysubstance abuse
2009
Age-Dependent Alterations of Corticostriatal Activity in the YAC128 Mouse Model of Huntington Disease
Joshi PR, Wu NP, André VM, Cummings DM, Cepeda C, Joyce JA, Carroll JB, Leavitt BR, Hayden MR, Levine MS, Bamford NS. Age-Dependent Alterations of Corticostriatal Activity in the YAC128 Mouse Model of Huntington Disease. Journal Of Neuroscience 2009, 29: 2414-2427. PMID: 19244517, PMCID: PMC2670193, DOI: 10.1523/jneurosci.5687-08.2009.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgingAnalysis of VarianceAnimalsBiophysicsCadmiumCells, CulturedCerebral CortexChromosomes, Artificial, YeastCorpus StriatumDisease Models, AnimalDopamine AgentsDose-Response Relationship, DrugElectric StimulationExcitatory Amino Acid AgentsExcitatory Postsynaptic PotentialsHumansHuntington DiseaseIn Vitro TechniquesMembrane PotentialsMiceNeural PathwaysNeuronsPyridinium CompoundsQuaternary Ammonium CompoundsStatistics, NonparametricTime FactorsTrinucleotide Repeat ExpansionConceptsYAC128 mouse modelGlutamate releaseCorticostriatal pathwayHuntington's diseaseCorticostriatal activityMouse modelSynaptic currentsMedium spiny neuronsAge-dependent alterationsGenetic neurodegenerative disorderAge-dependent changesBehavioral phenotypesSpiny neuronsCortical neuronsDisease progressionReceptor modulationSynaptic dysregulationDegenerative changesBrain slicesCorticostriatal functionPresynaptic terminalsCognitive deficitsNeurodegenerative disordersDiseaseMonths
2004
Dopamine Modulates Release from Corticostriatal Terminals
Bamford NS, Robinson S, Palmiter RD, Joyce JA, Moore C, Meshul CK. Dopamine Modulates Release from Corticostriatal Terminals. Journal Of Neuroscience 2004, 24: 9541-9552. PMID: 15509741, PMCID: PMC6730145, DOI: 10.1523/jneurosci.2891-04.2004.Peer-Reviewed Original ResearchConceptsCorticostriatal terminalsMedium spiny neuronsD2 receptorsDD miceSpiny neuronsD2-like receptor agonist quinpiroleExtracellular striatal glutamateFM1-43 destainingNormal striatal functionReserpine-treated miceCortical glutamatergic neuronsReceptor agonist quinpiroleActivity-dependent releaseMidbrain dopamine neuronsFM1-43Styryl dye FM1-43Aberrant cytoarchitectureGlutamate densityStriatal stimulationStriatal glutamateDopamine depletionAgonist quinpiroleControl miceDopamine deficiencyGlutamatergic neurons