2024
Localization and function of humanized F508del-CFTR in mouse intestine following activation of serum glucocorticoid kinase 1 and Trikafta
Dastoor P, Muiler C, Garrison A, Egan M, Carlos Dos Reis D, Santos A, Ameen N. Localization and function of humanized F508del-CFTR in mouse intestine following activation of serum glucocorticoid kinase 1 and Trikafta. European Journal Of Pharmacology 2024, 978: 176771. PMID: 38925289, DOI: 10.1016/j.ejphar.2024.176771.Peer-Reviewed Original ResearchSerum glucocorticoid kinase 1Glucocorticoid kinase 1F508del-CFTRCystic fibrosisMouse modelF508del-CFTR miceCFTR-expressing epithelial cellsCF mouse modelsHumanized mouse modelTreatment of ratsIntestinal diseaseIntestinal segmentsKinase 1CFTR modulatorsCFTR mutationsCF patientsTrikaftaDex treatmentLung diseaseEfficacy of compoundsDelta F508CFTRCombined treatmentEpithelial cellsLoss of function
2023
555 Elexacaftor-tezacaftor-ivacaftor and serum glucocorticoid kinase 1 activation on humanized dF508 mouse intestine
Ameen N, Dastoor P, dos Reis D, Barone C, Garrison A, Egan M. 555 Elexacaftor-tezacaftor-ivacaftor and serum glucocorticoid kinase 1 activation on humanized dF508 mouse intestine. Journal Of Cystic Fibrosis 2023, 22: s293-s294. DOI: 10.1016/s1569-1993(23)01478-9.Peer-Reviewed Original Research