2023
Proteomic profiling demonstrates inflammatory and endotheliopathy signatures associated with impaired cardiopulmonary exercise hemodynamic profile in Post Acute Sequelae of SARS‐CoV‐2 infection (PASC) syndrome
Singh I, Leitner B, Wang Y, Zhang H, Joseph P, Lutchmansingh D, Gulati M, Possick J, Damsky W, Hwa J, Heerdt P, Chun H. Proteomic profiling demonstrates inflammatory and endotheliopathy signatures associated with impaired cardiopulmonary exercise hemodynamic profile in Post Acute Sequelae of SARS‐CoV‐2 infection (PASC) syndrome. Pulmonary Circulation 2023, 13: e12220. PMID: 37091121, PMCID: PMC10113513, DOI: 10.1002/pul2.12220.Peer-Reviewed Original ResearchInvasive cardiopulmonary exercise testPASC patientsPost-acute sequelaeAcute sequelaeInfection syndromeUnexplained exertional intoleranceCardiopulmonary exercise testSystemic oxygen deliveryPersistent inflammatory stateVenous blood plasmaExertional intolerancePeak exerciseEndothelial dysfunctionHemodynamic profileInflammatory stateExercise testFibrotic processPathophysiological hallmarkAberrant protein expressionExpression of proteinsOxygen deliveryOxygen extractionProteomic profilingPatientsPhysiologic responses
2019
Peripheral Blood Proteomic Profiling to Distinguish Disease Biomarkers in the Multicenter IPF-PRO Registry Cohort
Todd J, Durham K, Overton R, Neely M, Belperio J, Gulati M, Huang H, Roman J, Newby L, Noth I, Vinisko R, Liu Y, Hesslinger C, Leonard T, Flaherty K, Palmer S, on behalf of the IPF-PRO Registry i. Peripheral Blood Proteomic Profiling to Distinguish Disease Biomarkers in the Multicenter IPF-PRO Registry Cohort. 2019, a4325-a4325. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a4325.Peer-Reviewed Original Research