2021
Coagulopathy, Bleeding Events, and Outcome According to Rotational Thromboelastometry in Patients With Acute Liver Injury/Failure
Stravitz RT, Fontana RJ, Meinzer C, Durkalski‐Mauldin V, Hanje AJ, Olson J, Koch D, Hamid B, Schilsky M, McGuire B, Ganger D, Liou I, Karvellas CJ, Rule JA, Lisman T, Clasen K, Reuben A, Cripps M, Lee WM, Group A. Coagulopathy, Bleeding Events, and Outcome According to Rotational Thromboelastometry in Patients With Acute Liver Injury/Failure. Hepatology 2021, 74: 937-949. PMID: 33636020, PMCID: PMC10668528, DOI: 10.1002/hep.31767.Peer-Reviewed Original ResearchConceptsALI/ALFROTEM parametersRotational thromboelastometryDisease severityAcute liver injury/failureAbnormal hemostatic profileSevere systemic complicationsAcute liver injuryBleeding eventsBleeding riskLiver transplantationSystemic complicationsHemostatic failureLiver injuryIllness severityNative liverAbnormal hemostasisHemostatic profileStudy groupHigh incidencePatientsNormal rangeLaboratory evidenceClot formationClot stability
2015
Prospective Pilot Study of a Single Daily Dosage of Trientine for the Treatment of Wilson Disease
Ala A, Aliu E, Schilsky ML. Prospective Pilot Study of a Single Daily Dosage of Trientine for the Treatment of Wilson Disease. Digestive Diseases And Sciences 2015, 60: 1433-1439. PMID: 25605552, PMCID: PMC4427615, DOI: 10.1007/s10620-014-3495-6.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, OralAdultAgedChelating AgentsDrug Administration ScheduleFemaleHepatolenticular DegenerationHumansMaleMedication AdherenceMiddle AgedPatient DropoutsPatient SatisfactionPilot ProjectsProspective StudiesSurveys and QuestionnairesTime FactorsTreatment OutcomeTrientineYoung AdultConceptsSingle daily doseWilson's diseaseDaily doseDaily treatment regimenStable Wilson's diseaseProspective pilot studyLiver synthetic functionSingle daily dosageEnd of treatmentResultsAll patientsMaintenance therapyTreatment regimenDaily dosageLifelong therapyLarge trialsZinc excretionUrine copperTreatment stoppageSide effectsTreatment efficacyTrientineTherapyPatientsPilot studyDiseaseTherapeutic hypothermia in acute liver failure: A multicenter retrospective cohort analysis
Karvellas CJ, Stravitz R, Battenhouse H, Lee WM, Schilsky ML, Group F. Therapeutic hypothermia in acute liver failure: A multicenter retrospective cohort analysis. Liver Transplantation 2015, 21: 4-12. PMID: 25308108, PMCID: PMC4939841, DOI: 10.1002/lt.24021.Peer-Reviewed Original ResearchMeSH KeywordsAcetaminophenAdultAnalgesics, Non-NarcoticBrain EdemaChemical and Drug Induced Liver InjuryChi-Square DistributionFemaleHumansHypothermia, InducedLiver Failure, AcuteLogistic ModelsMaleMiddle AgedMultivariate AnalysisOdds RatioRegistriesRetrospective StudiesRisk FactorsTime FactorsTreatment OutcomeUnited StatesConceptsAcute liver failureNon-APAP patientsALF patientsTherapeutic hypothermiaAPAP patientsLiver failureUS Acute Liver Failure Study GroupAcute Liver Failure Study GroupImpact of THMulticenter retrospective cohort analysisTransplant-free survival rateEnd-stage liver diseaseAPAP-ALF patientsRetrospective cohort studyRetrospective cohort analysisAcetaminophen patientsSpontaneous survivalCerebral edemaCohort studyProspective trialHepatic encephalopathyLiver diseaseTracheal infectionGrade IIIWorse outcomes
2013
Human Monoclonal Antibody MBL-HCV1 Delays HCV Viral Rebound Following Liver Transplantation: A Randomized Controlled Study
Chung R, Gordon F, Curry M, Schiano T, Emre S, Corey K, Markmann J, Hertl M, Pomposelli J, Pomfret E, Florman S, Schilsky M, Broering T, Finberg R, Szabo G, Zamore P, Khettry U, Babcock G, Ambrosino D, Leav B, Leney M, Smith H, Molrine D. Human Monoclonal Antibody MBL-HCV1 Delays HCV Viral Rebound Following Liver Transplantation: A Randomized Controlled Study. American Journal Of Transplantation 2013, 13: 1047-1054. PMID: 23356386, PMCID: PMC3618536, DOI: 10.1111/ajt.12083.Peer-Reviewed Original ResearchConceptsLiver transplantationHepatitis C virusViral reboundViral loadPlacebo-controlled pilot studyAntibody-treated groupDays of transplantResistance-associated variantsHCV genotype 1aHuman monoclonal antibodyAllograft infectionRibavirin therapyPlacebo groupActing antiviralsPlacebo treatmentMedian timeViral clearanceSingle infusionC virusHCV E2Median changeGenotype 1aLimited efficacyDay 1Day 3
2008
Screening for Wilson disease in acute liver failure: A comparison of currently available diagnostic tests
Korman JD, Volenberg I, Balko J, Webster J, Schiodt FV, Squires RH, Fontana RJ, Lee WM, Schilsky ML, Groups P. Screening for Wilson disease in acute liver failure: A comparison of currently available diagnostic tests. Hepatology 2008, 48: 1167-1174. PMID: 18798336, PMCID: PMC4881751, DOI: 10.1002/hep.22446.Peer-Reviewed Original ResearchConceptsAcute liver failureDiagnosis of ALFSerum copper levelsFulminant Wilson's diseaseWilson's diseaseLiver failureDiagnostic sensitivityEmergency liver transplantationChronic liver diseaseAlkaline phosphataseAvailable diagnostic testsCopper levelsAvailable laboratory testsALF patientsTransplant listingLikelihood ratioLiver transplantationSerum aminotransferasesLiver diseaseALT ratioSerum ceruloplasminBilirubin ratioPatientsSerum CpRapid diagnosis
2005
Survival after liver transplantation in patients with hepatic iron overload: the national hemochromatosis transplant registry.
Kowdley K, Brandhagen D, Gish R, Bass N, Weinstein J, Schilsky M, Fontana R, McCashland T, Cotler S, Bacon B, Keeffe E, Gordon F, Polissar N. Survival after liver transplantation in patients with hepatic iron overload: the national hemochromatosis transplant registry. Gastroenterology 2005, 129: 494-503. PMID: 16083706, DOI: 10.1016/j.gastro.2005.05.004.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAnalysis of VarianceCause of DeathCohort StudiesConfidence IntervalsFemaleGenetic MarkersGenotypeHemochromatosisHistocompatibility Antigens Class IHumansIron OverloadLiver Function TestsLiver TransplantationMaleMiddle AgedMutationProbabilityPrognosisProportional Hazards ModelsRegistriesSensitivity and SpecificitySeverity of Illness IndexSurvival AnalysisConceptsHepatic iron overloadHepatic iron indexHepatic iron concentrationLiver transplantationIron overloadPosttransplantation survivalC282Y/H63D mutationsEnd-stage liver diseaseHFE gene testingHFE mutation statusLiver transplantation centerNon-HH patientsOrgan Sharing statusYear of transplantationWild-type patientsPostliver transplantationTransplant RegistryHazard ratioTransplantation centersUncontrolled studiesLiver diseasePoor outcomeUnited NetworkIron indicesEarly diagnosis
2001
ORTHOTOPIC LIVER TRANSPLANTATION FOR WILSON’S DISEASE
Emre S, Atillasoy E, Ozdemir S, Schilsky M, Varma C, Thung S, Sternlieb I, Guy S, Sheiner P, Schwartz M, Miller C. ORTHOTOPIC LIVER TRANSPLANTATION FOR WILSON’S DISEASE. Transplantation 2001, 72: 1232-1236. PMID: 11602847, DOI: 10.1097/00007890-200110150-00008.Peer-Reviewed Original ResearchConceptsOrthotopic liver transplantationOne-year patientFulminant Wilson's diseaseLiver transplantationWilson's diseaseGraft survivalRenal failureDisease cureAcute renal failureLate postoperative complicationsChronic liver diseaseFulminant liver failureNormal liver functionLong-term survivalHepatic complicationsPost-OLTBiliary copper excretionPostoperative complicationsPatient agePatient demographicsSupportive careDisease recurrenceLiver failureLiver injuryMedical therapy
1998
Fractionation of Rat Hepatocyte Subpopulations with Varying Metabolic Potential, Proliferative Capacity, and Retroviral Gene Transfer Efficiency
Rajvanshi P, Liu D, Ott M, Gagandeep S, Schilsky M, Gupta S. Fractionation of Rat Hepatocyte Subpopulations with Varying Metabolic Potential, Proliferative Capacity, and Retroviral Gene Transfer Efficiency. Experimental Cell Research 1998, 244: 405-419. PMID: 9806791, DOI: 10.1006/excr.1998.4223.Peer-Reviewed Original ResearchConceptsH4 cellsGene expressionRetroviral gene transfer efficiencyHepatocyte subpopulationsMetabolic potentialCellular DNA synthesisLiver growth controlComplex cytoplasmRetroviral gene transferGrowth controlHepatic gene expressionGene transferHepatocyte growth factorBiosynthetic rateCell proliferationDNA synthesisGene transfer efficiencyViral receptorsProliferative capacityPolyploid hepatocytesGrowth factorCytoplasmCellsBiological differencesCytoplasmic ratioIdentification of B10, an alkaline phosphodiesterase of the apical plasma membrane of hepatocytes and biliary cells, in rat serum: Increased levels following bile duct ligation and during the development of cholangiocarcinoma
Meerson N, Delautier D, Durand‐Schneider A, Moreau A, Schilsky M, Sternlieb I, Feldmann G, Maurice M. Identification of B10, an alkaline phosphodiesterase of the apical plasma membrane of hepatocytes and biliary cells, in rat serum: Increased levels following bile duct ligation and during the development of cholangiocarcinoma. Hepatology 1998, 27: 563-568. PMID: 9462658, DOI: 10.1002/hep.510270234.Peer-Reviewed Original Research
1995
An array of mitochondrial alterations in the hepatocytes of long‐evans cinnamon rats
Sternlieb I, Quintana N, Volenberg I, Schilsky M. An array of mitochondrial alterations in the hepatocytes of long‐evans cinnamon rats. Hepatology 1995, 22: 1782-1787. PMID: 7489989, DOI: 10.1002/hep.1840220626.Peer-Reviewed Original ResearchConditional immortalization of gunn rat hepatocytes: An ex vivo model for evaluating methods for bilirubin‐UDP‐glucuronosyltransferase gene transfer
Fox I, Chowdhury N, Gupta S, Kondapalli R, Schilsky M, Stockert R, Chowdhury J. Conditional immortalization of gunn rat hepatocytes: An ex vivo model for evaluating methods for bilirubin‐UDP‐glucuronosyltransferase gene transfer. Hepatology 1995, 21: 837-846. PMID: 7875682, DOI: 10.1002/hep.1840210334.Peer-Reviewed Original ResearchConceptsLarge T antigenSV40 large T antigenGene transfer vectorsT antigenGunn rat hepatocytesMutant SV40 large T antigenImmortalized cellsPrimary hepatocytesTransfer vectorsRecombinant Moloney murine leukemia virusMoloney murine leukemia virusMurine leukemia virusCorresponding mRNAExpression of albuminT promoterRat hepatocytesConditional immortalizationASGRGene transferCell growthViral vectorsBilirubin UGTDNA synthesisUDP-glucuronosyltransferase deficiencyHepatocyte clones
1994
Liver transplantation for Wilson's disease: Indications and outcome
Schilsky M, Scheinberg I, Sternlieb I. Liver transplantation for Wilson's disease: Indications and outcome. Hepatology 1994, 19: 583-587. PMID: 8119682, DOI: 10.1002/hep.1840190307.Peer-Reviewed Original ResearchConceptsOrthotopic liver transplantationLiver transplantationNeurological Wilson's diseaseHepatic insufficiencyWilson's diseaseFulminant hepatitisSevere hepatic insufficiencyManagement of patientsIntractable neurological diseasesNonfatal complicationsGastrointestinal hemorrhageVascular complicationsMedian survivalMedical therapyRetrospective reviewPsychiatric manifestationsStudy groupPsychiatric symptomsPatientsTransplantationNeurological diseasesInsufficiencyDiseaseTransplantHepatitis
1991
Prognosis of Wilsonian chronic active hepatitis
Schilsky M, Scheinberg I, Sternlieb I. Prognosis of Wilsonian chronic active hepatitis. Gastroenterology 1991, 100: 762-767. PMID: 1993498, DOI: 10.1016/0016-5085(91)80023-3.Peer-Reviewed Original ResearchConceptsChronic active hepatitisActive hepatitisWilson's diseaseD-penicillamineAbnormal water retentionPresence of cirrhosisMonths of treatmentSuccessful pharmacological treatmentMajority of subjectsLiver transplantSalt restrictionLaboratory featuresSymptomatic improvementLiver diseaseTherapeutic regimenPharmacological treatmentAlanine aminotransferasePatientsAspartate aminotransferaseHepatitisNormal levelsDiseaseCirrhosisTrientinePrognosis