2000
A Primitive ATP Receptor from the Little Skate Raja erinacea *
Dranoff J, O'Neill A, Franco A, Cai S, Connolly G, Ballatori N, Boyer J, Nathanson M. A Primitive ATP Receptor from the Little Skate Raja erinacea *. Journal Of Biological Chemistry 2000, 275: 30701-30706. PMID: 10900200, DOI: 10.1074/jbc.m003366200.Peer-Reviewed Original ResearchConceptsLittle skate Raja erinaceaSkate Raja erinaceaDegenerate oligonucleotide probeRaja erinaceaP2Y receptor pharmacologySingle polymerase chain reaction productXenopus oocyte expression systemLiver cDNA libraryATP receptorsHigher organismsEvolutionary forerunnerCommon ancestorOocyte expression systemPhylogenetic analysisP2Y receptorsCDNA clonesPrimitive organismsCDNA libraryGene productsSubstrate preferenceMolecular basisExpression systemNucleotide specificityMammalian tissuesRange of nucleotidesMolecular identification of a primitive P2Y ATP receptor in liver from the little skate Raja erinacea
Dranoff J, O’Neill A, Cai S, Franco A, Connelly G, Ballatori N, Boyer J, Nathanson M. Molecular identification of a primitive P2Y ATP receptor in liver from the little skate Raja erinacea. Gastroenterology 2000, 118: a911. DOI: 10.1016/s0016-5085(00)85777-7.Peer-Reviewed Original Research
1994
Effects of protein kinase C and cytosolic Ca2+ on exocytosis in the isolated perfused rat liver
Bruck R, Nathanson M, Roelofsen H, Boyer J. Effects of protein kinase C and cytosolic Ca2+ on exocytosis in the isolated perfused rat liver. Hepatology 1994, 20: 1032-1040. PMID: 7927205, DOI: 10.1002/hep.1840200436.Peer-Reviewed Original ResearchConceptsProtein kinase CKinase CApical exocytosisRegulation of exocytosisProtein kinase C inhibitor HHorseradish peroxidase concentrationCytosolic Ca2ExocytosisCell typesInhibitor HProtein kinase C activator phorbol dibutyrateHorseradish peroxidase excretionPhorbol dibutyrateCa2Rat liverRelative importanceNet excretionPeroxidase concentrationsHepatocytes
1993
Effects of tauroursodeoxycholic acid on cytosolic Ca2+ signals in isolated rat hepatocytes
Beuers U, Nathanson M, Boyer J. Effects of tauroursodeoxycholic acid on cytosolic Ca2+ signals in isolated rat hepatocytes. Gastroenterology 1993, 104: 604-612. PMID: 8425704, DOI: 10.1016/0016-5085(93)90433-d.Peer-Reviewed Original ResearchConceptsEffect of TUDCATauroursodeoxycholic acidAdministration of TUDCAIP3-independent mechanismCytosolic free calciumIP3-sensitive Ca2Trihydroxy bile acidsCholestatic disordersHepatocyte secretionTreatment periodExtracellular Ca2Bile acidsTaurolithocholic acidMumol/Rat hepatocytesFree calciumBasal levelsTransient increaseCytosolic Ca2Levels of inositolFree mediumPhysiological concentrationsIsolated rat hepatocytesHepatocytesFourfold increase
1992
Effects of Ca2+ agonists on cytosolic Ca2+ in isolated hepatocytes and on bile secretion in the isolated perfused rat liver
Nathanson M, Gautam A, Bruck R, Isales C, Boyer J. Effects of Ca2+ agonists on cytosolic Ca2+ in isolated hepatocytes and on bile secretion in the isolated perfused rat liver. Hepatology 1992, 15: 107-116. PMID: 1727785, DOI: 10.1002/hep.1840150119.Peer-Reviewed Original ResearchConceptsBile flowPerfusion pressureBile secretionCytosolic Ca2Rat liverProtein kinase CIonophore-induced increaseBromo-A23187Hepatic vasoconstrictionVasodilator papaverineProtein kinase C inhibitor HExtracellular Ca2Kinase CSecretionLiverVasopressinAgonist vasopressinBenzohydroquinoneEffect of Ca2HepatocytesActivate protein kinase CInhibitor HTwo-thirdsIsolated hepatocytesSensitive photoprotein aequorin
1991
Mechanisms and regulation of bile secretion
Nathanson M, Boyer J. Mechanisms and regulation of bile secretion. Hepatology 1991, 14: 551-566. PMID: 1874500, DOI: 10.1002/hep.1840140324.Peer-Reviewed Original Research