2024
Association Between Body Mass Index, Testing Performance And Clinical Outcomes In Patients With Stable Chest Pain: Insights From The PRECISE (Prospective Randomized Trial Of The Optimal Evaluation Of Cardiac Symptoms And Revascularization) Trial
Ferencik M, Vemulapalli S, Nanna M, Kelsey M, Mark D, Leipsic J, Ng N, Maurovich-Horvat P, Mullen S, Rogers C, Udelson J, Douglas P. Association Between Body Mass Index, Testing Performance And Clinical Outcomes In Patients With Stable Chest Pain: Insights From The PRECISE (Prospective Randomized Trial Of The Optimal Evaluation Of Cardiac Symptoms And Revascularization) Trial. Journal Of Cardiovascular Computed Tomography 2024, 18: s38. DOI: 10.1016/j.jcct.2024.05.087.Peer-Reviewed Original ResearchMachine learning prediction of one-year mortality after percutaneous coronary intervention in acute coronary syndrome patients
Hosseini K, Behnoush A, Khalaji A, Etemadi A, Soleimani H, Pasebani Y, Jenab Y, Masoudkabir F, Tajdini M, Mehrani M, Nanna M. Machine learning prediction of one-year mortality after percutaneous coronary intervention in acute coronary syndrome patients. International Journal Of Cardiology 2024, 409: 132191. PMID: 38777044, DOI: 10.1016/j.ijcard.2024.132191.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionLogistic regressionPost-PCI mortalityPrediction of one-year mortalityCoronary interventionPrediction of 1-year mortalityBody mass indexAcute coronary syndrome patientsOne-year mortalityIndividual-level assessmentsReceiver operating characteristic curveAcute coronary syndromeCoronary syndrome patientsTehran Heart CenterRates of comorbiditiesMass indexHigher ageSyndrome patientsCoronary syndromeHeart CenterFollow-upLipid profileU-shaped correlationPatientsCharacteristic curveFrailty in the cardiac intensive care unit: assessment and impact
Moumneh M, Jamil Y, Kalra K, Ijaz N, Campbell G, Kochar A, Nanna M, van Diepen S, Damluji A. Frailty in the cardiac intensive care unit: assessment and impact. European Heart Journal Acute Cardiovascular Care 2024, 13: 506-514. PMID: 38525951, PMCID: PMC11214587, DOI: 10.1093/ehjacc/zuae039.Peer-Reviewed Original ResearchCardiac intensive care unitIntensive care unitCardiac intensive care unit admissionCare unitAcute cardiovascular illnessHigher comorbidity burdenAcute cardiovascular conditionsYears of ageOptimal therapyYounger patientsClinical outcomesFrail patientsClinical syndromeComorbidity burdenPhysiological reserveCardiovascular diseasePatientsCardiovascular conditionsGeriatric syndromesCardiovascular illnessFrailtyOlder adultsCognitive function
2023
Trends and Inhospital Outcomes of Intravascular Imaging on Single-Vessel Coronary Chronic Total Occlusion Treated With Percutaneous Coronary Intervention
Park D, Hu J, Kanitsoraphan C, Al-Ogaili A, Murthi M, Vardar U, Ahmad Y, Nanna M, Vij A. Trends and Inhospital Outcomes of Intravascular Imaging on Single-Vessel Coronary Chronic Total Occlusion Treated With Percutaneous Coronary Intervention. The American Journal Of Cardiology 2023, 206: 79-85. PMID: 37683583, PMCID: PMC10901566, DOI: 10.1016/j.amjcard.2023.08.051.Peer-Reviewed Original ResearchPercutaneous coronary interventionChronic total occlusionInhospital mortalityIntravascular ultrasoundOptical coherence tomographyInhospital outcomesIntravascular imagingCoronary interventionTotal occlusionCTO-PCISingle-vessel chronic total occlusionSingle-vessel percutaneous coronary interventionCoronary chronic total occlusionsUse of IVUSLarge national analysisUse of OCTIVUS useOCT useCoherence tomographyLogistic regressionPatientsAbsolute numberCochran-ArmitageMortalityLess increaseInsight Into the Optimal Timing of Percutaneous Coronary Intervention and Transcatheter Aortic Valve Replacement
Park D, Simonato M, Ahmad Y, Banks A, Lowenstern A, Nanna M. Insight Into the Optimal Timing of Percutaneous Coronary Intervention and Transcatheter Aortic Valve Replacement. Current Problems In Cardiology 2023, 49: 102050. PMID: 37643698, PMCID: PMC10924682, DOI: 10.1016/j.cpcardiol.2023.102050.Peer-Reviewed Original ResearchTranscatheter aortic valve replacementPercutaneous coronary artery interventionAcute kidney injuryAortic valve replacementKidney injuryValve replacementPercutaneous coronary interventionCoronary artery diseaseCoronary artery interventionPaucity of dataHospital mortalityNonhome dischargeCoronary interventionSecondary outcomesSelect patientsArtery diseaseArtery interventionClinical outcomesHigher oddsPCI timingPatientsReadmissionOptimal timingSame daySignificant differencesAssessment and Management of Older Adults Undergoing PCI, Part 1 A JACC: Advances Expert Panel
Nanna M, Sutton N, Kochar A, Rymer J, Lowenstern A, Gackenbach G, Hummel S, Goyal P, Rich M, Kirkpatrick J, Krishnaswami A, Alexander K, Forman D, Bortnick A, Batchelor W, Damluji A, Councils A. Assessment and Management of Older Adults Undergoing PCI, Part 1 A JACC: Advances Expert Panel. JACC Advances 2023, 2: 100389. PMID: 37584013, PMCID: PMC10426754, DOI: 10.1016/j.jacadv.2023.100389.Peer-Reviewed Original ResearchHigh-risk percutaneous coronary interventionOlder adultsProportion of patientsPercutaneous coronary interventionHigh-risk groupCardiac catheterization laboratoryConventional risk assessment toolsRisk assessment toolCardiovascular riskCoronary interventionGeriatric syndromesGeriatric domainsCardiovascular SocietyProcedural riskCatheterization laboratoryHemodynamic riskPopulation agesDisproportionate riskExpert panelStructured risk assessmentPatientsRiskAdultsAssessment toolMorbidityD-22 | Trajectories of Patients Treated With Beta Blockers and Calcium Channel Blockers for Stable Ischemic Heart Disease and Diabetes Mellitus (from the Bypass Angioplasty Revascularization Investigation 2 Diabetes Trial)
Jamil Y, Park D, Chongthammakun V, Al Damluji A, Nanna M. D-22 | Trajectories of Patients Treated With Beta Blockers and Calcium Channel Blockers for Stable Ischemic Heart Disease and Diabetes Mellitus (from the Bypass Angioplasty Revascularization Investigation 2 Diabetes Trial). Journal Of The Society For Cardiovascular Angiography & Interventions 2023, 2: 100876. DOI: 10.1016/j.jscai.2023.100876.Peer-Reviewed Original ResearchCarcinoid Heart Disease-Induced Right-Sided Heart Failure as a Culprit for Significant Ascites
Huang Y, Park D, Almoghrabi A, Nanna M. Carcinoid Heart Disease-Induced Right-Sided Heart Failure as a Culprit for Significant Ascites. Case Reports In Gastroenterology 2023, 17: 179-184. PMID: 36974060, PMCID: PMC10039415, DOI: 10.1159/000529633.Peer-Reviewed Original ResearchCarcinoid heart diseaseDiagnosis of carcinoid heart diseaseManagement of carcinoid heart diseaseSerum-ascites albumin gradientHeart diseaseAlcohol use disorderSignificant ascitesNeuroendocrine neoplasmsPortal hypertensionCase reportAlbumin gradientHeart failurePhysical examinationEarly diagnosisUse disorderAscitesFluid analysisPatient outcomesPeritoneal fluid analysisDiagnosisMultidisciplinary approachPatientsEarly interventionDiseaseRelevant specialistsClinical and cost implications of deferred testing in low-risk patients with stable chest pain: a simulation using the PROMISE trial
Nanna M, Yow E, Vemulapalli S, Mark D, Kelsey M, Patel M, Al-Khalidi H, Rogers C, Udelson J, Douglas P. Clinical and cost implications of deferred testing in low-risk patients with stable chest pain: a simulation using the PROMISE trial. American Heart Journal 2023, 261: 124-126. PMID: 36828202, PMCID: PMC10903188, DOI: 10.1016/j.ahj.2023.02.010.Peer-Reviewed Original Research
2022
Lipid‐lowering treatment among older patients with atherosclerotic cardiovascular disease
Nanna M, Nelson A, Haynes K, Shambhu S, Eapen Z, Cziraky M, Calvert S, Pagidipati N, Granger C. Lipid‐lowering treatment among older patients with atherosclerotic cardiovascular disease. Journal Of The American Geriatrics Society 2022, 71: 1243-1249. PMID: 36538393, PMCID: PMC10089944, DOI: 10.1111/jgs.18172.Peer-Reviewed Original ResearchConceptsHigh-intensity statinsLipid-lowering therapyModerate-intensity statinsU.S. older adultsOlder adultsPCSK9 inhibitorsNon-statin lipid-lowering therapyMulticenter retrospective cohort studyRetrospective cohort studyMinority of patientsAtherosclerotic cardiovascular diseaseCoronary artery diseaseEligible older adultsCohort studyOlder patientsOverall cohortArtery diseaseIntensive treatmentCardiovascular diseaseASCVDSecondary measuresStatinsUntreated individualsPatientsTherapyDeprescription of aspirin for primary prevention is uncommon at discharge in hospitalised patients with gastrointestinal bleeding
Li D, Ong S, Hughes M, Hung K, Agarwal R, Alexis J, Damianos J, Sharma S, Pires J, Nanna M, Laine L. Deprescription of aspirin for primary prevention is uncommon at discharge in hospitalised patients with gastrointestinal bleeding. Alimentary Pharmacology & Therapeutics 2022, 57: 94-102. PMID: 36394111, DOI: 10.1111/apt.17278.Peer-Reviewed Original ResearchConceptsMajor adverse cardiovascular eventsGastrointestinal bleedingPrimary preventionCardiovascular eventsRisk of MACEYale-New Haven HospitalPrimary cardiovascular preventionAdverse cardiovascular eventsKaplan-Meier curvesLong-term outcomesRisk-benefit ratioLog-rank testAspirin 81Hospitalised patientsPrimary endpointSecondary endpointsCardiovascular preventionSubsequent hospitalisationMedian ageDeprescriptionHigh riskAspirinHospitalisationPatientsPreventionChoice of antihypertensive agent in isolated systolic hypertension and isolated diastolic hypertension: A secondary analysis of the ALLHAT trial
Wang SY, Hanna JM, Gongal P, Onuma O, Nanna MG. Choice of antihypertensive agent in isolated systolic hypertension and isolated diastolic hypertension: A secondary analysis of the ALLHAT trial. American Heart Journal 2022, 254: 30-34. PMID: 35932912, PMCID: PMC10908340, DOI: 10.1016/j.ahj.2022.07.006.Peer-Reviewed Original ResearchConceptsDiastolic hypertensionSystolic hypertensionAntihypertensive agentsSecondary analysisPrevent Heart Attack TrialBroad treatment recommendationsDifferent antihypertensive agentsUse of chlorthalidoneLipid-Lowering TreatmentHeart Attack TrialCoronary heart diseaseCause mortalityPrimary outcomeAttack TrialALLHAT trialHeart diseaseTreatment recommendationsHypertensionPatientsTrialsAntihypertensivesAmlodipineLisinoprilStrokeAgentsFrailty and outcomes following revascularization of lower-extremity peripheral artery disease: Insights from the Vascular Quality Initiative (VQI)
Al-Damluji MS, Smolderen KG, Meng C, Dai F, Nanna MG, Sumpio B, Henke P, Mena-Hurtado C. Frailty and outcomes following revascularization of lower-extremity peripheral artery disease: Insights from the Vascular Quality Initiative (VQI). Vascular Medicine 2022, 27: 251-257. PMID: 35485400, DOI: 10.1177/1358863x221083701.Peer-Reviewed Original ResearchConceptsRisk Analysis IndexVascular Quality InitiativeLower extremity revascularizationFrailty screening toolsMFI-5Lower extremity peripheral artery diseaseScreening toolFrailty detectionAddition of frailtyPAD risk factorsPeripheral artery diseasePAD populationRevascularization typeVascular cohortMajor amputationPerioperative outcomesArtery diseaseFrailty indexFrailty toolsAdjusted analysisUnplanned amputationRisk factorsHigher oddsPredictive valuePatientsPROGNOSTIC VALIDITY OF FRAILTY ASSESSMENT TOOLS IN PREDICTION OF MORTALITY AND MAJOR AMPUTATION IN PATIENTS UNDERGOING REVASCULARIZATION FOR LOWER EXTREMITY ARTERIAL DISEASE
Nikooie R, Smolderen K, Al-Damluji M, Meng C, Dai F, Nanna M, Sumpio B, Henke P, Mena-Hurtado C. PROGNOSTIC VALIDITY OF FRAILTY ASSESSMENT TOOLS IN PREDICTION OF MORTALITY AND MAJOR AMPUTATION IN PATIENTS UNDERGOING REVASCULARIZATION FOR LOWER EXTREMITY ARTERIAL DISEASE. Journal Of The American College Of Cardiology 2022, 79: 1779. DOI: 10.1016/s0735-1097(22)02770-x.Peer-Reviewed Original Research
2021
Moving the Field Forward: Untangling the Impact of Frailty on Patients With Advanced Heart Failure and on Prognosticating Outcomes
Clark KAA, Nanna MG. Moving the Field Forward: Untangling the Impact of Frailty on Patients With Advanced Heart Failure and on Prognosticating Outcomes. Journal Of Cardiac Failure 2021, 28: 775-777. PMID: 34936895, PMCID: PMC9106896, DOI: 10.1016/j.cardfail.2021.12.006.Peer-Reviewed Original Research
2020
In ACS, ticagrelor and prasugrel each reduce some ischemic events but increase major bleeding vs. clopidogrel.
Nanna MG, Granger CB. In ACS, ticagrelor and prasugrel each reduce some ischemic events but increase major bleeding vs. clopidogrel. Annals Of Internal Medicine 2020, 173: jc44. PMID: 33075264, DOI: 10.7326/acpj202010200-044.Peer-Reviewed Original ResearchPresentation, Treatment, and Outcomes of the Oldest-Old Patients with Acute Myocardial Infarction: The SILVER-AMI Study
Gupta A, Tsang S, Hajduk A, Krumholz HM, Nanna MG, Green P, Dodson JA, Chaudhry SI. Presentation, Treatment, and Outcomes of the Oldest-Old Patients with Acute Myocardial Infarction: The SILVER-AMI Study. The American Journal Of Medicine 2020, 134: 95-103. PMID: 32805225, PMCID: PMC7752813, DOI: 10.1016/j.amjmed.2020.07.020.Peer-Reviewed Original ResearchConceptsOldest-old patientsMyocardial infarctionFunctional impairmentOlder patientsMobility impairmentsCox proportional hazards regressionMiddle-old patientsProportional hazards regressionAcute myocardial infarctionCase fatality rateAcute myocardial infarction hospitalizationsSILVER-AMI StudyYears of ageMyocardial infarction hospitalizationsChest painCoronary revascularizationAtypical presentationHazards regressionClinical variablesRisk factorsAdvanced agePrimary symptomsPatientsFatality rateHealth statusWeight change in heart failure inpatients not associated with 30-day readmission
Nanna MG, Sullivan AE, Bazylevska V, Wong R, Murphy TE, Bellumkonda L, McNamara RL. Weight change in heart failure inpatients not associated with 30-day readmission. Future Cardiology 2020, 16: 289-296. PMID: 32286858, PMCID: PMC7607390, DOI: 10.2217/fca-2019-0047.Peer-Reviewed Original ResearchConceptsHF-specific readmissionsHeart failureWeight changeWeight lossHeart failure inpatientsHospital weight lossDecompensated heart failureShort-term readmissionHF inpatientsCause readmissionDischarge weightSingle centerReadmissionLogistic regressionPatientsInpatientsCauseAssociationWeight dataAdmissionEVALUATING THE 2018 AHA/ACC LIPID GUIDELINE PERFORMANCE TO IDENTIFY PATIENTS AT HIGH RISK FOR PREMATURE CARDIOVASCULAR DISEASE
Zeitouni M, Nanna M, Sun J, Chiswell K, Peterson E, Navar A. EVALUATING THE 2018 AHA/ACC LIPID GUIDELINE PERFORMANCE TO IDENTIFY PATIENTS AT HIGH RISK FOR PREMATURE CARDIOVASCULAR DISEASE. Journal Of The American College Of Cardiology 2020, 75: 1981. DOI: 10.1016/s0735-1097(20)32608-5.Peer-Reviewed Original Research
2019
PRACTICE-LEVEL VARIATION IN STATIN USE AND LDL-C CONTROL IN THE UNITED STATES: RESULTS FROM THE PATIENT AND PROVIDER ASSESSMENT OF LIPID MANAGEMENT (PALM) REGISTRY
Nanna M, Navar A, Wang T, Li S, Li Z, Robinson J, Roger V, Virani S, Wilson P, Goldberg A, Koren A, Louie M, Peterson E. PRACTICE-LEVEL VARIATION IN STATIN USE AND LDL-C CONTROL IN THE UNITED STATES: RESULTS FROM THE PATIENT AND PROVIDER ASSESSMENT OF LIPID MANAGEMENT (PALM) REGISTRY. Journal Of The American College Of Cardiology 2019, 73: 1706. DOI: 10.1016/s0735-1097(19)32312-5.Peer-Reviewed Original Research