2024
Quality of Life in Older Adults With Stable Ischemic Heart Disease and Diabetes Mellitus: A Post Hoc Analysis of the BARI 2D Trial
Park D, Jamil Y, Moumneh M, Batchelor B W, Nanna M, Damluji A. Quality of Life in Older Adults With Stable Ischemic Heart Disease and Diabetes Mellitus: A Post Hoc Analysis of the BARI 2D Trial. The American Journal Of Cardiology 2024, 223: 58-69. PMID: 38797195, PMCID: PMC11214881, DOI: 10.1016/j.amjcard.2024.05.016.Peer-Reviewed Original ResearchDuke Activity Status IndexOlder adultsYears of follow-upStable ischemic heart diseaseIntensive medical therapyQoL measuresStatus indexIschemic heart diseaseDistress ratingsOlder adult populationOlder adult patientsBARI 2D trialDiabetes mellitusQuality of lifeQuality-of-lifeHeart diseaseMultivariate linear regressionFollow-upMedical therapyAdult populationQoLCognitive impairmentOlder patientsPost hoc analysisChronic total occlusion
2023
Do Clinical Outcomes and Quality of Life Differ by the Number of Antianginals for Stable Ischemic Heart Disease? Insights from the BARI 2D Trial
Jamil Y, Park D, Verde L, Sherwood M, Tehrani B, Batchelor W, Frampton J, Damluji A, Nanna M. Do Clinical Outcomes and Quality of Life Differ by the Number of Antianginals for Stable Ischemic Heart Disease? Insights from the BARI 2D Trial. The American Journal Of Cardiology 2023, 214: 66-76. PMID: 38160927, PMCID: PMC10923116, DOI: 10.1016/j.amjcard.2023.12.045.Peer-Reviewed Original ResearchStable ischemic heart diseaseAnti-anginal agentIntensive medical therapyIschemic heart diseaseMedical therapyQOL metricsHeart diseaseFindings merit further researchMajor adverse cardiovascular eventsAnti-anginal treatmentBARI 2D trialGreater QoL improvementAdverse cardiovascular eventsMyocardial jeopardy indexCardiovascular eventsCause mortalityCardiovascular endpointsClinical confoundersPatient characteristicsDiabetes mellitusHeart failureTherapy intensityClinical outcomesQOL improvementMyocardial infarctionBeyond MACE: a multidimensional approach to outcomes in clinical trials for older adults with stable ischemic heart disease
Kalra K, Moumneh M, Nanna M, Damluji A. Beyond MACE: a multidimensional approach to outcomes in clinical trials for older adults with stable ischemic heart disease. Frontiers In Cardiovascular Medicine 2023, 10: 1276370. PMID: 38045910, PMCID: PMC10690830, DOI: 10.3389/fcvm.2023.1276370.Peer-Reviewed Original ResearchStable ischemic heart diseaseIschemic heart diseaseClinical trialsOlder adult populationOlder adultsHeart diseaseHealth outcomesAdult populationMajor adverse cardiovascular outcomesHigh cardiovascular riskAdverse cardiovascular outcomesMultiple chronic diseasesPatient-centered approachCardiovascular clinical trialsPoor health outcomesMore effective careQuality of lifeHolistic health outcomesCardiovascular outcomesCardiovascular riskGeriatric syndromesRandomized trialsPatient populationPatient preferencesChronic diseasesComplex Percutaneous Coronary Intervention Outcomes in Older Adults
Hanna J, Wang S, Kochar A, Park D, Damluji A, Henry G, Ahmad Y, Curtis J, Nanna M. Complex Percutaneous Coronary Intervention Outcomes in Older Adults. Journal Of The American Heart Association 2023, 12: e029057. PMID: 37776222, PMCID: PMC10727245, DOI: 10.1161/jaha.122.029057.Peer-Reviewed Original ResearchConceptsNoncomplex percutaneous coronary interventionsComplex percutaneous coronary interventionStable ischemic heart diseasePercutaneous coronary interventionIschemic heart diseaseTarget lesion revascularizationEvent-free survivalHeart diseaseOlder adultsCause deathLesion revascularizationClinical characteristicsElective percutaneous coronary interventionPercutaneous coronary intervention outcomesWorse event-free survivalMedical therapy useCox regression modelLarge health systemNoncardiac comorbiditiesRevascularization riskCoronary interventionTherapy useClinical outcomesDisease featuresLower riskD-22 | Trajectories of Patients Treated With Beta Blockers and Calcium Channel Blockers for Stable Ischemic Heart Disease and Diabetes Mellitus (from the Bypass Angioplasty Revascularization Investigation 2 Diabetes Trial)
Jamil Y, Park D, Chongthammakun V, Al Damluji A, Nanna M. D-22 | Trajectories of Patients Treated With Beta Blockers and Calcium Channel Blockers for Stable Ischemic Heart Disease and Diabetes Mellitus (from the Bypass Angioplasty Revascularization Investigation 2 Diabetes Trial). Journal Of The Society For Cardiovascular Angiography & Interventions 2023, 2: 100876. DOI: 10.1016/j.jscai.2023.100876.Peer-Reviewed Original ResearchD-24 | Quality of Life After Revascularization versus Medical Therapy in Older Adults With Stable Ischemic Heart Disease at 5 Year Follow-up in the BARI2D Trial
Park D, Jamil Y, Chongthammakun V, Nanna M, Al Damluji A. D-24 | Quality of Life After Revascularization versus Medical Therapy in Older Adults With Stable Ischemic Heart Disease at 5 Year Follow-up in the BARI2D Trial. Journal Of The Society For Cardiovascular Angiography & Interventions 2023, 2: 100878. DOI: 10.1016/j.jscai.2023.100878.Peer-Reviewed Original ResearchManagement of Stable Angina in the Older Adult Population
Nanna M, Wang S, Damluji A. Management of Stable Angina in the Older Adult Population. Circulation Cardiovascular Interventions 2023, 16: e012438. PMID: 36916288, PMCID: PMC10121835, DOI: 10.1161/circinterventions.122.012438.Peer-Reviewed Original ResearchConceptsStable ischemic heart diseaseIschemic heart diseaseStable anginaHeart diseaseOlder adultsOlder patientsGuideline-recommended treatment optionsGoals of careComplex treatment decisionsOlder Adult PopulationAdverse eventsYounger patientsMedical therapyClinical presentationGreater morbidityTreatment optionsSubgroup analysisOverall burdenHigh burdenObservational studyTreatment decisionsPatient prioritiesAnginaAdult populationEnd point
2022
Readmission and adverse outcomes after percutaneous coronary intervention in patients with dementia
Park D, Hu J, Alexander K, Nanna M. Readmission and adverse outcomes after percutaneous coronary intervention in patients with dementia. Journal Of The American Geriatrics Society 2022, 71: 1034-1046. PMID: 36409823, PMCID: PMC10089937, DOI: 10.1111/jgs.18120.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionInhospital adverse eventsKidney injuryAdverse eventsCoronary interventionAdverse outcomesHigher readmission riskMultivariable Cox modelingAcute kidney injuryThirty-day readmissionIschemic heart diseaseCox proportional hazardsLogistic regression modelingDiagnosis of dementiaInhospital mortalityNoncardiac proceduresIndex hospitalizationReadmission ratesCox modelingReadmission riskCardiac arrestHeart diseasePCI experienceHigher oddsReadmissionIn-hospital outcomes and readmission in older adults treated with percutaneous coronary intervention for stable ischemic heart disease
Park DY, Hanna JM, Kadian S, Kadian M, Jones WS, Damluji AA, Kochar A, Curtis JP, Nanna MG. In-hospital outcomes and readmission in older adults treated with percutaneous coronary intervention for stable ischemic heart disease. Journal Of Geriatric Cardiology 2022, 19: 631-642. PMID: 36284680, PMCID: PMC9548058, DOI: 10.11909/j.issn.1671-5411.2022.09.006.Peer-Reviewed Original ResearchStable ischemic heart diseasePercutaneous coronary interventionInpatient percutaneous coronary interventionIschemic heart diseaseHospital mortalityOlder adultsIndex hospitalizationCoronary interventionHospital chargesHeart diseaseNational Readmission DatabaseTotal hospital chargesHigh-risk cohortOlder adult patientsPeriprocedural morbidityCardiovascular causesGastrointestinal hemorrhageHospital lengthHospital outcomesAdult patientsSecondary outcomesLonger LOSPrimary outcomeIntracranial hemorrhageProcedural risk