2024
Frailty in the cardiac intensive care unit: assessment and impact
Moumneh M, Jamil Y, Kalra K, Ijaz N, Campbell G, Kochar A, Nanna M, van Diepen S, Damluji A. Frailty in the cardiac intensive care unit: assessment and impact. European Heart Journal Acute Cardiovascular Care 2024, 13: 506-514. PMID: 38525951, PMCID: PMC11214587, DOI: 10.1093/ehjacc/zuae039.Peer-Reviewed Original ResearchCardiac intensive care unitIntensive care unitCardiac intensive care unit admissionCare unitAcute cardiovascular illnessHigher comorbidity burdenAcute cardiovascular conditionsYears of ageOptimal therapyYounger patientsClinical outcomesFrail patientsClinical syndromeComorbidity burdenPhysiological reserveCardiovascular diseasePatientsCardiovascular conditionsGeriatric syndromesCardiovascular illnessFrailtyOlder adultsCognitive functionRole of Cognitive Frailty in Older Adults With Cardiovascular Disease
Ijaz N, Jamil Y, Brown C, Krishnaswami A, Orkaby A, Stimmel M, Gerstenblith G, Nanna M, Damluji A. Role of Cognitive Frailty in Older Adults With Cardiovascular Disease. Journal Of The American Heart Association 2024, 13: e033594. PMID: 38353229, PMCID: PMC11010094, DOI: 10.1161/jaha.123.033594.Peer-Reviewed Original ResearchConceptsCognitive frailtyCardiovascular diseaseDecreased cognitive reserveOlder adult populationCognitive impairmentEvidence of dementiaPresence of cognitive impairmentTargeted intervention studiesSedentary behaviorTobacco usePhysical frailtyOlder adultsGeriatric syndromesIntervention studiesCardiovascular cliniciansFrailtyAdult populationAssociated with poor outcomesCognitive reserveRisk factorsOlder patientsCliniciansPoor outcomeTherapeutic strategiesPathophysiological underpinningsChronic Coronary Disease in Older Adults
Ambrosini A, Fishman E, Damluji A, Nanna M. Chronic Coronary Disease in Older Adults. Medical Clinics Of North America 2024, 108: 581-594. PMID: 38548465, PMCID: PMC11040602, DOI: 10.1016/j.mcna.2023.12.004.Peer-Reviewed Original Research
2023
Beyond MACE: a multidimensional approach to outcomes in clinical trials for older adults with stable ischemic heart disease
Kalra K, Moumneh M, Nanna M, Damluji A. Beyond MACE: a multidimensional approach to outcomes in clinical trials for older adults with stable ischemic heart disease. Frontiers In Cardiovascular Medicine 2023, 10: 1276370. PMID: 38045910, PMCID: PMC10690830, DOI: 10.3389/fcvm.2023.1276370.Peer-Reviewed Original ResearchStable ischemic heart diseaseIschemic heart diseaseClinical trialsOlder adult populationOlder adultsHeart diseaseHealth outcomesAdult populationMajor adverse cardiovascular outcomesHigh cardiovascular riskAdverse cardiovascular outcomesMultiple chronic diseasesPatient-centered approachCardiovascular clinical trialsPoor health outcomesMore effective careQuality of lifeHolistic health outcomesCardiovascular outcomesCardiovascular riskGeriatric syndromesRandomized trialsPatient populationPatient preferencesChronic diseasesLife’s Essential 8 Optimizing Health in Older Adults
Kumar M, Orkaby A, Tighe C, Villareal D, Billingsley H, Nanna M, Kwak M, Rohant N, Patel S, Goyal P, Hummel S, Al-Malouf C, Kolimas A, Krishnaswami A, Rich M, Kirkpatrick J, Damluji A, Kuchel G, Forman D, Alexander K. Life’s Essential 8 Optimizing Health in Older Adults. JACC Advances 2023, 2: 100560. PMID: 37664644, PMCID: PMC10470487, DOI: 10.1016/j.jacadv.2023.100560.Peer-Reviewed Original ResearchClinical cardiovascular diseaseOlder adultsPrevention targetsTraditional CVD risk factorsCVD-free survivalCVD risk factorsGoals of careAmerican Heart AssociationQuality of lifeGeriatric syndromesHeart AssociationRisk factorsCardiovascular diseaseHigh prevalenceCell exhaustionChronologic ageSleep healthOlder individualsMitochondrial dysfunctionStem cell exhaustionResult of advancesCellular senescenceAdultsPublic healthIntercellular communicationA Geriatric Approach to Percutaneous Coronary Interventions in Older Adults, Part II A JACC: Advances Expert Panel
Nanna M, Sutton N, Kochar A, Rymer J, Lowenstern A, Gackenbach G, Hummel S, Goyal P, Rich M, Kirkpatrick J, Krishnaswami A, Alexander K, Forman D, Bortnick A, Batchelor W, Damluji A. A Geriatric Approach to Percutaneous Coronary Interventions in Older Adults, Part II A JACC: Advances Expert Panel. JACC Advances 2023, 2: 100421. PMID: 37575202, PMCID: PMC10419335, DOI: 10.1016/j.jacadv.2023.100421.Peer-Reviewed Original ResearchPercutaneous coronary interventionCoronary interventionOlder adultsPreprocedural risk assessmentGoals of carePatient-centered outcomesInterventional cardiology practiceOlder adult populationHeart team membersGeriatric approachOlder patientsHeart teamGeriatric syndromesPharmacotherapeutic considerationsGeriatric specialistsCardiology practiceGeriatric principlesGeriatric risksAdult populationExpert panelAdultsRisk assessmentInterventionFacilitate uptakeCurrent knowledgeAssessment and Management of Older Adults Undergoing PCI, Part 1 A JACC: Advances Expert Panel
Nanna M, Sutton N, Kochar A, Rymer J, Lowenstern A, Gackenbach G, Hummel S, Goyal P, Rich M, Kirkpatrick J, Krishnaswami A, Alexander K, Forman D, Bortnick A, Batchelor W, Damluji A, Councils A. Assessment and Management of Older Adults Undergoing PCI, Part 1 A JACC: Advances Expert Panel. JACC Advances 2023, 2: 100389. PMID: 37584013, PMCID: PMC10426754, DOI: 10.1016/j.jacadv.2023.100389.Peer-Reviewed Original ResearchHigh-risk percutaneous coronary interventionOlder adultsProportion of patientsPercutaneous coronary interventionHigh-risk groupCardiac catheterization laboratoryConventional risk assessment toolsRisk assessment toolCardiovascular riskCoronary interventionGeriatric syndromesGeriatric domainsCardiovascular SocietyProcedural riskCatheterization laboratoryHemodynamic riskPopulation agesDisproportionate riskExpert panelStructured risk assessmentPatientsRiskAdultsAssessment toolMorbidity