2001
Intestinal and Hemodynamic Impairment Following Mesenteric Ischemia/Reperfusion
Khanna A, Rossman J, Fung H, Caty M. Intestinal and Hemodynamic Impairment Following Mesenteric Ischemia/Reperfusion. Journal Of Surgical Research 2001, 99: 114-119. PMID: 11421612, DOI: 10.1006/jsre.2001.6103.Peer-Reviewed Original ResearchConceptsMean arterial pressureR injuryRat modelHeart rateAnimal modelsMesenteric ischemia/reperfusionBarrier functionReperfusion injury resultsSuperior mesenteric arteryIschemia/reperfusionNormal barrier functionArterial pressureHemodynamic effectsIntestinal damageMesenteric occlusionHemodynamic measurementsMesenteric arterySmall bowelFemoral arterySustained fallIntestinal permeabilityInjury resultsAnesthetized ratsIntestinal impairmentHistological disruption
1997
Mucosal Protection from Intestinal Ischemia–Reperfusion Reduces Oxidant Injury to the Lung
Rossman J, Caty M, Zheng S, Karamanoukian H, Thusu K, Azizkhan R, Dandona P. Mucosal Protection from Intestinal Ischemia–Reperfusion Reduces Oxidant Injury to the Lung. Journal Of Surgical Research 1997, 73: 41-46. PMID: 9441791, DOI: 10.1006/jsre.1997.5196.Peer-Reviewed Original ResearchConceptsIntestinal mucosal injuryLung injuryMucosal injuryOxygenated perfluorocarbonLipid peroxidationDistant organ injuryIntestinal ischemia reperfusionLung lipid peroxidationPortal venous circulationPortal venous effluentOrgan injuryIschemia reperfusionMucosal protectionPortal bloodVenous effluentVenous circulationLung tissueLuminal perfusionIntraluminal oxygenOxidant injurySmall intestineInjuryOxidant generationReactive oxygen speciesPrimary effectorOxygenated intraluminal perfluorocarbon protects intestinal muscosa from ischemia/reperfusion injury
O'Donnell K, Caty M, Zheng S, Rossman J, Azizkhan R. Oxygenated intraluminal perfluorocarbon protects intestinal muscosa from ischemia/reperfusion injury. Journal Of Pediatric Surgery 1997, 32: 361-365. PMID: 9044154, DOI: 10.1016/s0022-3468(97)90211-6.Peer-Reviewed Original ResearchConceptsIschemia/reperfusion injurySuperior mesenteric arteryMucosal injuryReperfusion injuryMucosal integrityOxygenated perfluorocarbonNew treatment modalitiesR groupMesenteric insufficiencyR injuryMesenteric arteryMucosal functionTreatment modalitiesIntraluminal perfusionMucosal preservationIschemic disordersRat modelIntraluminal flowIntestinal mucosaClinical situationsInjuryIschemiaTissue sectionsReperfusionFeasible technique