2002
Bladder cancer detection with urinary survivin, an inhibitor of apoptosis.
Sharp JD, Hausladen DA, Maher MG, Wheeler MA, Altieri DC, Weiss RM. Bladder cancer detection with urinary survivin, an inhibitor of apoptosis. Frontiers In Bioscience-Landmark 2002, 7: e36-41. PMID: 11815300, DOI: 10.2741/sharp.Peer-Reviewed Original ResearchMeSH KeywordsApoptosisBiomarkersCarcinoma, Transitional CellChromosomal Proteins, Non-HistoneCystoscopyCytodiagnosisHumansImmunoblottingInhibitor of Apoptosis ProteinsMicrotubule-Associated ProteinsNeoplasm ProteinsNeoplasm Recurrence, LocalSensitivity and SpecificitySurvivinUrinary Bladder Neoplasms
1998
Expression of AP-2 transcription factors in human breast cancer correlates with the regulation of multiple growth factor signalling pathways.
Turner B, Zhang J, Gumbs A, Maher M, Kaplan L, Carter D, Glazer P, Hurst H, Haffty B, Williams T. Expression of AP-2 transcription factors in human breast cancer correlates with the regulation of multiple growth factor signalling pathways. Cancer Research 1998, 58: 5466-72. PMID: 9850080.Peer-Reviewed Original ResearchMeSH KeywordsBinding SitesBreastBreast NeoplasmsDNA-Binding ProteinsEpitheliumFemaleHumansImmunohistochemistryPrognosisPromoter Regions, GeneticReceptor, ErbB-2Receptor, IGF Type 1Receptors, EstrogenReceptors, Growth FactorReceptors, ProgesteroneSignal TransductionTranscription Factor AP-2Transcription FactorsTumor Cells, CulturedUp-RegulationConceptsAP-2 transcription factorsAP-2-binding sitesTranscription factorsAP-2gammaAP-2alphaAP-2 gene familyAP-2 geneAP-2 family membersInsulin-like growth factor I receptorAP-2 familySignal transduction moleculesAP-2 proteinsAP-2alpha proteinMammalian developmentGene familyHuman breast cancerGrowth factor receptorTransduction moleculesProximal promoterBreast cancerReceptor promoterMultiple growth factorsBreast cancer cell linesCell growthAP-2gamma expressionPrognostic significance of colony-stimulating factor receptor expression in ipsilateral breast cancer recurrence.
Maher M, Sapi E, Turner B, Gumbs A, Perrotta P, Carter D, Kacinski B, Haffty B. Prognostic significance of colony-stimulating factor receptor expression in ipsilateral breast cancer recurrence. Clinical Cancer Research 1998, 4: 1851-6. PMID: 9717811.Peer-Reviewed Original ResearchConceptsIpsilateral breast tumor recurrenceCSF-1R antibodyCSF-1R expressionIpsilateral breast cancer recurrenceBreast tumor recurrenceBreast cancer patientsBreast cancer recurrencePoor prognostic roleColony-stimulating factor receptor expressionCSF-1RFactor receptor expressionEarly stage IBreast carcinoma cellsDifferentiation of macrophagesConservative surgeryControl patientsLocal relapseNodal statusPrognostic roleDistant metastasisClinical stagePrognostic significanceCancer patientsTumor recurrenceCancer recurrence
1997
Recognition of activated CSF-1 receptor in breast carcinomas by a tyrosine 723 phosphospecific antibody
Flick M, Sapi E, Perrotta P, Maher M, Halaban R, Carter D, Kacinski B. Recognition of activated CSF-1 receptor in breast carcinomas by a tyrosine 723 phosphospecific antibody. Oncogene 1997, 14: 2553-2561. PMID: 9191055, DOI: 10.1038/sj.onc.1201092.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsAntibodiesAntibody SpecificityBreast NeoplasmsCarcinoma in SituCells, CulturedCross ReactionsEpitopesFibroblastsGenes, fmsHumansImmunohistochemistryMacrophagesMiceMice, Inbred BALB CPhosphopeptidesPhosphorylationPhosphotyrosineProto-Oncogene MasReceptor, Macrophage Colony-Stimulating FactorTumor Cells, CulturedConceptsCSF-1RMultiple signal transduction pathwaysC-fms proto-oncogenePhosphorylation state-specific antibodiesSignal transduction pathwaysCSF-1 receptorAnchorage-independent growthImmunoblots of lysatesActivation/phosphorylationEffector proteinsVivo phosphorylationCytoplasmic domainDifferentiation of macrophagesPhosphospecific antibodiesTransduction pathwaysCellular phenotypesInvasive human breast tumoursSpecific phosphopeptidesC-fms oncogeneCSF-1Proto-oncogeneHuman breast carcinomaFirst direct evidenceNormal proliferationFactor receptor