2022
Trends in characteristics, management, and outcomes of patients presenting with gastrointestinal bleeding to emergency departments in the United States from 2006 to 2019
Zheng NS, Tsay C, Laine L, Shung DL. Trends in characteristics, management, and outcomes of patients presenting with gastrointestinal bleeding to emergency departments in the United States from 2006 to 2019. Alimentary Pharmacology & Therapeutics 2022, 56: 1543-1555. PMID: 36173090, PMCID: PMC9669230, DOI: 10.1111/apt.17238.Peer-Reviewed Original ResearchConceptsGastrointestinal bleedingLength of stayEmergency departmentMultivariable analysisIncidence of GIBRed blood cell transfusionNationwide Emergency Department SampleBlood cell transfusionIncidence of patientsOutcomes of patientsSex-adjusted incidenceEmergency Department SampleCase fatality rateRecent epidemiologic studiesProportion of casesED dischargeMore comorbiditiesCell transfusionRBC transfusionMore patientsComorbid populationEpidemiological evaluationInpatient costsPrimary diagnosisEpidemiologic studies
2021
Fresh frozen plasma transfusion in acute variceal haemorrhage: Results from a multicentre cohort study
Mohanty A, Kapuria D, Canakis A, Lin H, Amat MJ, Paniz G, Placone NT, Thomasson R, Roy H, Chak E, Baffy G, Curry MP, Laine L, Rustagi T. Fresh frozen plasma transfusion in acute variceal haemorrhage: Results from a multicentre cohort study. Liver International 2021, 41: 1901-1908. PMID: 33969607, DOI: 10.1111/liv.14936.Peer-Reviewed Original ResearchConceptsAcute variceal hemorrhageFresh frozen plasma transfusionFrozen plasma transfusionFFP transfusionLength of stayPlasma transfusionVariceal hemorrhageCohort studyClinical outcomesEnd-stage liver disease (MELD) scoreStage liver disease scoreTertiary health care centerSevere variceal bleedingLiver Disease scoreMulticentre cohort studyRetrospective cohort studyHigh-risk patientsOdds of mortalityPoor clinical outcomeHealth care centersMultivariable regression analysisEligible patientsActive bleedingVariceal bleedingMultivariable analysis
2016
No Benefit From Platelet Transfusion for Gastrointestinal Bleeding in Patients Taking Antiplatelet Agents
Zakko L, Rustagi T, Douglas M, Laine L. No Benefit From Platelet Transfusion for Gastrointestinal Bleeding in Patients Taking Antiplatelet Agents. Clinical Gastroenterology And Hepatology 2016, 15: 46-52. PMID: 27464591, DOI: 10.1016/j.cgh.2016.07.017.Peer-Reviewed Original ResearchConceptsGastrointestinal bleedingAntiplatelet agentsPlatelet transfusionsCardiovascular eventsNon-variceal upper gastrointestinal bleedingYale-New Haven HospitalRecurrent gastrointestinal bleedingSerious gastrointestinal bleedingMajor cardiovascular eventsRetrospective cohort studySevere gastrointestinal bleedingUpper gastrointestinal bleedingLower blood pressureMultivariable regression analysisHigher heart rateLack of benefitRecurrent bleedingBaseline characteristicsCohort studyBlood pressurePrimary outcomeSuch patientsHemoglobin levelsMultivariable analysisIntensive care
2008
Systematic Review of the Predictors of Recurrent Hemorrhage After Endoscopic Hemostatic Therapy for Bleeding Peptic Ulcers
Elmunzer BJ, Young SD, Inadomi JM, Schoenfeld P, Laine L. Systematic Review of the Predictors of Recurrent Hemorrhage After Endoscopic Hemostatic Therapy for Bleeding Peptic Ulcers. The American Journal Of Gastroenterology 2008, 103: ajg2008521. PMID: 18684171, DOI: 10.1111/j.1572-0241.2008.02070.x.Peer-Reviewed Original ResearchConceptsEndoscopic therapyIndependent predictorsRecurrent hemorrhageProspective studySystematic reviewIntensive care unit observationLarge ulcer sizePosterior duodenal ulcerSecond-look endoscopyEndoscopic hemostatic therapySignificant independent predictorsPrespecified inclusion criteriaComorbid illnessesHemodynamic instabilityHemostatic therapyDuodenal ulcerEndoscopic predictorsPrimary outcomeUlcer sizeMultivariable analysisPooled ratePeptic ulcerClinical managementBibliographic database searchInclusion criteriaLower Gastrointestinal Events in a Double-Blind Trial of the Cyclo-Oxygenase-2 Selective Inhibitor Etoricoxib and the Traditional Nonsteroidal Anti-Inflammatory Drug Diclofenac
Laine L, Curtis SP, Langman M, Jensen DM, Cryer B, Kaur A, Cannon CP. Lower Gastrointestinal Events in a Double-Blind Trial of the Cyclo-Oxygenase-2 Selective Inhibitor Etoricoxib and the Traditional Nonsteroidal Anti-Inflammatory Drug Diclofenac. Gastroenterology 2008, 135: 1517-1525. PMID: 18823986, DOI: 10.1053/j.gastro.2008.07.067.Peer-Reviewed Original ResearchMeSH KeywordsAgedAnti-Inflammatory Agents, Non-SteroidalConfidence IntervalsCyclooxygenase InhibitorsDiclofenacDose-Response Relationship, DrugEtoricoxibFemaleFollow-Up StudiesGastrointestinal HemorrhageHumansIncidenceMaleMiddle AgedOdds RatioOsteoarthritisProspective StudiesPyridinesRisk FactorsSulfonesTreatment OutcomeConceptsLower GI eventsClinical eventsGI eventsRisk factorsCOX-2 selective inhibitorsBlinded adjudication committeeLower Gastrointestinal EventsTraditional NSAID diclofenacUpper GI eventsDouble-blind trialSignificant risk factorsMajor risk factorAnti-inflammatory drugsSelective inhibitorNonsteroidal anti-inflammatory drug diclofenacGastrointestinal eventsNSAID useProspective trialMultivariable analysisRheumatoid arthritisAdjudication committeeMean durationCyclo-oxygenaseNSAID diclofenacAbstractText