2004
Indications of Linkage and Association of Gilles de la Tourette Syndrome in Two Independent Family Samples: 17q25 Is a Putative Susceptibility Region
Paschou P, Feng Y, Pakstis A, Speed W, DeMille M, Kidd J, Jaghori B, Kurlan R, Pauls D, Sandor P, Barr C, Kidd K. Indications of Linkage and Association of Gilles de la Tourette Syndrome in Two Independent Family Samples: 17q25 Is a Putative Susceptibility Region. American Journal Of Human Genetics 2004, 75: 545-560. PMID: 15303240, PMCID: PMC1182043, DOI: 10.1086/424389.Peer-Reviewed Original ResearchMeSH KeywordsC-Reactive ProteinChromosome MappingChromosomes, Human, Pair 17Gene FrequencyGenetic LinkageGenetic Predisposition to DiseaseGenotypeHaplotypesHumansLinkage DisequilibriumLod ScoreMicrosatellite RepeatsMicrotubule-Associated ProteinsNerve Tissue ProteinsPedigreePolymorphism, Single NucleotideTourette SyndromeWhite PeopleConceptsSingle nucleotide polymorphismsLinkage disequilibriumSusceptibility regionsThree-site haplotypesPutative susceptibility regionsBackground linkage disequilibriumSignificant association resultsIndication of linkageNonparametric LOD scoreGenomic regionsThree-marker haplotypeComplex genetic backgroundAdditional microsatellite markersFine mappingGenetic basisHigher LD valuesMicrosatellite markersExpression profilesAssociation resultsTransmission/disequilibrium testChromosome 17Genetic componentGenetic backgroundGenesLOD score
1995
An international two–stage genome–wide search for schizophrenia susceptibility genes
Moises H, Yang L, Kristbjarnarson H, Wiese C, Byerley W, Macciardi F, Arolt V, Blackwood D, Liu X, Sjögren B, Aschauer H, Hwu H, Jang K, Livesley W, Kennedy J, Zoega T, Ivarsson O, Bui M, Yu M, Havsteen B, Commenges D, Weissenbach J, Schwinger E, Gottesman I, Pakstis A, Wetterberg L, Kidd K, Helgason T. An international two–stage genome–wide search for schizophrenia susceptibility genes. Nature Genetics 1995, 11: 321-324. PMID: 7581457, DOI: 10.1038/ng1195-321.Peer-Reviewed Original ResearchConceptsGenome-wide searchChromosome 6pIDDM susceptibility genesModel-free linkage analysisSchizophrenia susceptibility genesFine mappingOligogenic transmissionAssociation studiesLinkage analysisGeographical isolatesLinkage findingsSusceptibility genesGenesLocus heterogeneityLarge pedigreeComplex disorderSecond International Collaborative StudyComplex modesHLA regionMultifactorial disease