2021
PIWI-mediated control of tissue-specific transposons is essential for somatic cell differentiation
Li D, Taylor D, van Wolfswinkel J. PIWI-mediated control of tissue-specific transposons is essential for somatic cell differentiation. Cell Reports 2021, 37: 109776. PMID: 34610311, PMCID: PMC8532177, DOI: 10.1016/j.celrep.2021.109776.Peer-Reviewed Original ResearchConceptsPIWI-interacting RNAsPIWI proteinsCell differentiationDefective cell differentiationLineage-specific genesSubset of transposonsAdult pluripotent stem cellsSomatic cell differentiationStem cell systemStem cell biologyPluripotent stem cellsTransposon derepressionAnimal germlineSpecific chromatinRegenerative animalsPlanarian neoblastsCell biologyTransposonStem cellsProteinDifferentiationIntricate interplayCell systemAddition causesTissue dysfunction
2014
Piwi and Potency: PIWI Proteins in Animal Stem Cells and Regeneration
van Wolfswinkel JC. Piwi and Potency: PIWI Proteins in Animal Stem Cells and Regeneration. Integrative And Comparative Biology 2014, 54: 700-713. PMID: 24948137, DOI: 10.1093/icb/icu084.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsArgonaute ProteinsGene Expression RegulationRegenerationRNA, Small InterferingStem CellsConceptsPIWI proteinsSomatic stem cellsStem cellsDifferent animal phylaGerm cell lineageStem cell systemAnimal stem cellsAnimal germlineGermline developmentAncestral roleAnimal phylaDiverse animalsCell lineagesDifferentiation potentialProteinGermlineCell systemCellsSuch cellsPiwiPiRNAsPhylaLineagesTransposonAvailable reveals
2012
Differential Impact of the HEN1 Homolog HENN-1 on 21U and 26G RNAs in the Germline of Caenorhabditis elegans
Kamminga LM, van Wolfswinkel JC, Luteijn MJ, Kaaij LJ, Bagijn MP, Sapetschnig A, Miska EA, Berezikov E, Ketting RF. Differential Impact of the HEN1 Homolog HENN-1 on 21U and 26G RNAs in the Germline of Caenorhabditis elegans. PLOS Genetics 2012, 8: e1002702. PMID: 22829772, PMCID: PMC3400576, DOI: 10.1371/journal.pgen.1002702.Peer-Reviewed Original ResearchConceptsHENN-1G RNAAGO proteinsSRNA moleculesSmall RNAsGene expressionC. elegans piRNAsGermline-expressed genesSequence-specific recruitmentDifferent RNAi pathwaysGlobal gene expression analysisGlobal gene expressionLoss of methylationGene expression analysisEndogenous RNAiRNAi pathwayC. elegansRNA classesRNA displayGene activityRNA interferenceExpression analysisSequence specificityTarget RNARNA