2014
Whole-Body Acoel Regeneration Is Controlled by Wnt and Bmp-Admp Signaling
Srivastava M, Mazza-Curll K, van Wolfswinkel J, Reddien P. Whole-Body Acoel Regeneration Is Controlled by Wnt and Bmp-Admp Signaling. Current Biology 2014, 24: 1107-1113. PMID: 24768051, DOI: 10.1016/j.cub.2014.03.042.Peer-Reviewed Original ResearchConceptsWhole-body regenerationMolecular mechanismsLast common ancestorEarly branching positionDorsal-ventral axisYears of evolutionEnigmatic phylumBilaterian evolutionMolecular resourcesUnderlying molecular mechanismsSystemic RNAiAccessible embryosCommon ancestorHofsteniaPhylogenetic analysisVentral cellsAcoelsMolecular studiesTranscriptomePhylaRNAiPlanariansAncestorBranching positionModel system
2005
Assessment of potency of allergenic activity of low molecular weight compounds based on IL-1α and IL-18 production by a murine and human keratinocyte cell line
Van Och F, Van Loveren H, Van Wolfswinkel J, Machielsen A, Vandebriel R. Assessment of potency of allergenic activity of low molecular weight compounds based on IL-1α and IL-18 production by a murine and human keratinocyte cell line. Toxicology 2005, 210: 95-109. PMID: 15840424, DOI: 10.1016/j.tox.2005.01.004.Peer-Reviewed Original ResearchConceptsLocal lymph node assayPotency of allergensCytokine productionMurine local lymph node assayGuinea pig maximisation testIL-18 productionProduction of cytokinesLymph node assayHuman keratinocyte cell line HaCaT.Cell linesKeratinocyte cell line HaCaT.Assessment of potencyPresent studyIL-1αIL-1alphaStimulation indexHuman keratinocyte cell lineAnimal modelsAllergen concentrationsKeratinocyte cell lineDose-response dataVivo modelAllergenic potencyAllergenic activitySkin sensitisation