2023
Insights in piRNA targeting rules
van Wolfswinkel J. Insights in piRNA targeting rules. Wiley Interdisciplinary Reviews - RNA 2023, 15: e1811. PMID: 37632327, PMCID: PMC10895071, DOI: 10.1002/wrna.1811.Peer-Reviewed Original ResearchPIWI-interacting RNAsTarget transcriptsProtein-RNA interactionsRNA-RNA interactionsPotential target transcriptsPIWI proteinsProtein-RNARNA interactionsSequence complementarityCells of animalsTranscriptionEffective downregulationStructural studiesProteinPIWITransposonGermlineStem cellsRNATargetCleavageDownregulationDefense
2016
A widely employed germ cell marker is an ancient disordered protein with reproductive functions in diverse eukaryotes
Carmell M, Dokshin G, Skaletsky H, Hu Y, van Wolfswinkel J, Igarashi K, Bellott D, Nefedov M, Reddien P, Enders G, Uversky V, Mello C, Page D. A widely employed germ cell marker is an ancient disordered protein with reproductive functions in diverse eukaryotes. ELife 2016, 5: e19993. PMID: 27718356, PMCID: PMC5098910, DOI: 10.7554/elife.19993.Peer-Reviewed Original ResearchConceptsDedicated germlineMajor eukaryotic lineagesDNA damage repairGerm cell markersEukaryotic lineagesDiverse eukaryotesEukaryotic evolutionMulticellular organismsMulticellular animalsSexual reproductionEarly eukaryotesGenomic integrityPhylogenetic analysisAncient familyReproductive cellsDamage repairGene expressionEukaryotesHeritable genomeGerm cellsProteinStem cellsGCNAGermlineCell markers
2014
Piwi and Potency: PIWI Proteins in Animal Stem Cells and Regeneration
van Wolfswinkel JC. Piwi and Potency: PIWI Proteins in Animal Stem Cells and Regeneration. Integrative And Comparative Biology 2014, 54: 700-713. PMID: 24948137, DOI: 10.1093/icb/icu084.Peer-Reviewed Original ResearchConceptsPIWI proteinsSomatic stem cellsStem cellsDifferent animal phylaGerm cell lineageStem cell systemAnimal stem cellsAnimal germlineGermline developmentAncestral roleAnimal phylaDiverse animalsCell lineagesDifferentiation potentialProteinGermlineCell systemCellsSuch cellsPiwiPiRNAsPhylaLineagesTransposonAvailable reveals
2005
Chromatin and RNAi factors protect the C. elegans germline against repetitive sequences
Robert VJ, Sijen T, van Wolfswinkel J, Plasterk RH. Chromatin and RNAi factors protect the C. elegans germline against repetitive sequences. Genes & Development 2005, 19: 782-787. PMID: 15774721, PMCID: PMC1074315, DOI: 10.1101/gad.332305.Peer-Reviewed Original ResearchConceptsRepetitive sequencesRepetitive transgenesCaenorhabditis elegans germlineC. elegans germlineProtection of genomeRNA interference screenChromatin factorsRNAi factorsTranscriptional geneChromatin remodelingEndogenous genesInterference screenMolecular dataCatalog genesSelective silencingPutative roleGenesRNAiGermlineSequenceTransgeneTrans effectCosuppressionChromatinGenome