2016
Using the Ubiquitin-modified Proteome to Monitor Distinct and Spatially Restricted Protein Homeostasis Dysfunction*
Gendron JM, Webb K, Yang B, Rising L, Zuzow N, Bennett EJ. Using the Ubiquitin-modified Proteome to Monitor Distinct and Spatially Restricted Protein Homeostasis Dysfunction*. Molecular & Cellular Proteomics 2016, 15: 2576-2593. PMID: 27185884, PMCID: PMC4974337, DOI: 10.1074/mcp.m116.058420.Peer-Reviewed Original ResearchConceptsUbiquitylation eventsProtein homeostasisProtein populationHomeostasis dysfunctionGlobal protein homeostasisP97/VCPDistinct protein populationsQuantitative proteomics methodHomeostasis functionsUbiquitin-proteasome systemDistinct functional outcomesProteomic methodsProteasome systemSubcellular fractionationProteomeFluorescent reportersHuman pathologiesProteasome dysfunctionDistinct insultsUbReporterPotent inhibitorHomeostasisUnique alterationsKey role
2014
Using the ubiquitin‐modified proteome to monitor protein synthesis fidelity (353.1)
Bennett E, Webb K, Zuzow N, Gendron J. Using the ubiquitin‐modified proteome to monitor protein synthesis fidelity (353.1). The FASEB Journal 2014, 28 DOI: 10.1096/fasebj.28.1_supplement.353.1.Peer-Reviewed Original ResearchUbiquitin-modified proteomeUPS-dependent degradationUbiquitin-dependent destructionUbiquitylation eventsUbiquitylation substratesUbiquitylated proteinsProtein translationTranslation productsProteomic techniquesDeleterious accumulationLysine residuesHomeostasis functionsProteinDefense strategiesImmunoaffinity methodProteomeLarge poolTrypsinolysisResiduesPrevious studiesAccumulationPoolPeptides