2015
The Unfolded Protein Response Triggers Site-Specific Regulatory Ubiquitylation of 40S Ribosomal Proteins
Higgins R, Gendron JM, Rising L, Mak R, Webb K, Kaiser SE, Zuzow N, Riviere P, Yang B, Fenech E, Tang X, Lindsay SA, Christianson JC, Hampton RY, Wasserman SA, Bennett EJ. The Unfolded Protein Response Triggers Site-Specific Regulatory Ubiquitylation of 40S Ribosomal Proteins. Molecular Cell 2015, 59: 35-49. PMID: 26051182, PMCID: PMC4491043, DOI: 10.1016/j.molcel.2015.04.026.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsCell LineCell SurvivalDrosophilaEIF-2 KinaseEndoplasmic ReticulumEndoplasmic Reticulum StressEukaryotic Initiation Factor-2Gene Expression RegulationHumansMolecular Sequence DataPhosphorylationProtein BiosynthesisRibosome Subunits, Small, EukaryoticSaccharomyces cerevisiaeUbiquitinationUnfolded Protein ResponseConceptsUnfolded protein responseRegulatory ubiquitylationRibosomal proteinsUPR activationEukaryotic translational controlUbiquitin-dependent regulationER-resident proteinsChronic UPR activationTranslational reprogrammingER homeostasisTranslational controlCytoplasmic ribosomesProtein foldingTranslation inhibitionProtein responseUbiquitylationPERK signalingUbiquitin proteomicsOptimal cell survivalCell survivalProtein synthesisProteinDegradation capacityReprogrammingActivation
2007
A Proteomics Study of Brassinosteroid Response in Arabidopsis *
Deng Z, Zhang X, Tang W, Oses-Prieto JA, Suzuki N, Gendron JM, Chen H, Guan S, Chalkley RJ, Peterman TK, Burlingame AL, Wang ZY. A Proteomics Study of Brassinosteroid Response in Arabidopsis *. Molecular & Cellular Proteomics 2007, 6: 2058-2071. PMID: 17848588, PMCID: PMC2966871, DOI: 10.1074/mcp.m700123-mcp200.Peer-Reviewed Original ResearchConceptsTwo-dimensional DIGEProteomic studiesBiosynthesis of hormonesSpecific cellular processesPrevious microarray studyBri1-116Bzr1-1DBrassinosteroid responsesBR regulationBR actionVesicle traffickingBR responsesCellular processesRT-PCR analysisPosttranslational modificationsBrassinosteroidsCytoskeleton rearrangementMolecular detailsProtein responseBR treatmentPlant steroidsBR mutantsMolecular networksDiverse processesPhysiological processes