2007
An Essential Role for 14-3-3 Proteins in Brassinosteroid Signal Transduction in Arabidopsis
Gampala SS, Kim TW, He JX, Tang W, Deng Z, Bai MY, Guan S, Lalonde S, Sun Y, Gendron JM, Chen H, Shibagaki N, Ferl RJ, Ehrhardt D, Chong K, Burlingame AL, Wang ZY. An Essential Role for 14-3-3 Proteins in Brassinosteroid Signal Transduction in Arabidopsis. Developmental Cell 2007, 13: 177-189. PMID: 17681130, PMCID: PMC2000337, DOI: 10.1016/j.devcel.2007.06.009.Peer-Reviewed Original ResearchMeSH Keywords14-3-3 ProteinsAmino Acid SequenceArabidopsisArabidopsis ProteinsBinding SitesCell NucleusDNA-Binding ProteinsDNA, PlantDown-RegulationModels, BiologicalMolecular Sequence DataMutationNuclear ProteinsPhosphorylationPlant LeavesProtein BindingProtein KinasesProtein TransportSignal TransductionSteroids, HeterocyclicConceptsPlant growthTranscription factorsNuclear localizationGene expressionBZR2/BES1Brassinosteroid signal transductionSignal transduction pathwaysKey transcription factorRapid nuclear localizationBZR1 proteinCell surface receptorsBR regulationBR deficiencyTransgenic plantsGSK3 kinaseBR responsesCytoplasmic retentionSignal transductionTransduction pathwaysCytoplasmic localizationDNA bindingBrassinosteroidsBR treatmentBZR1Essential hormone
2002
The GSK3-like kinase BIN2 phosphorylates and destabilizes BZR1, a positive regulator of the brassinosteroid signaling pathway in Arabidopsis
He JX, Gendron JM, Yang Y, Li J, Wang ZY. The GSK3-like kinase BIN2 phosphorylates and destabilizes BZR1, a positive regulator of the brassinosteroid signaling pathway in Arabidopsis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2002, 99: 10185-10190. PMID: 12114546, PMCID: PMC126645, DOI: 10.1073/pnas.152342599.Peer-Reviewed Original ResearchMeSH KeywordsArabidopsisArabidopsis ProteinsCalcium-Calmodulin-Dependent Protein KinasesDNA-Binding ProteinsGene Expression Regulation, PlantGlycogen Synthase Kinase 3Glycogen Synthase KinasesGreen Fluorescent ProteinsLuminescent ProteinsNuclear ProteinsPhosphorylationPhytosterolsPlants, Genetically ModifiedProtein KinasesSignal TransductionConceptsPositive regulatorBZR2/BES1Two-hybrid assayBZR1 proteinReceptor BRI1BZR1Proteasome machineryBrassinosteroidsBIN2 activityNegative regulatorBIN2Protein accumulationRegulatorNormal growthDephosphorylationProteasome inhibitorsAccumulationBES1BRI1ArabidopsisPhosphorylatesSteroid hormonesMG132YeastPhosphorylationNuclear-Localized BZR1 Mediates Brassinosteroid-Induced Growth and Feedback Suppression of Brassinosteroid Biosynthesis
Wang Z, Nakano T, Gendron J, He J, Chen M, Vafeados D, Yang Y, Fujioka S, Yoshida S, Asami T, Chory J. Nuclear-Localized BZR1 Mediates Brassinosteroid-Induced Growth and Feedback Suppression of Brassinosteroid Biosynthesis. Developmental Cell 2002, 2: 505-513. PMID: 11970900, DOI: 10.1016/s1534-5807(02)00153-3.Peer-Reviewed Original ResearchConceptsBR biosynthesisBR signal transduction pathwayCell surface receptor kinasePlant steroid hormonesSignal transduction pathwaysBZR1 proteinBrassinosteroid biosynthesisBR responsesPositive regulatorReceptor kinaseTransduction pathwaysBrassinosteroidsBZR1Gene expressionDominant mutationsFeedback regulationBiosynthesisNuclear componentsMutationsRegulationPathwayBRI1Steroid hormonesKinaseHypocotyls