2007
The Spatial Distribution of Inositol 1,4,5-Trisphosphate Receptor Isoforms Shapes Ca2+ Waves*
Hernandez E, Leite MF, Guerra MT, Kruglov EA, Bruna-Romero O, Rodrigues MA, Gomes DA, Giordano FJ, Dranoff JA, Nathanson MH. The Spatial Distribution of Inositol 1,4,5-Trisphosphate Receptor Isoforms Shapes Ca2+ Waves*. Journal Of Biological Chemistry 2007, 282: 10057-10067. PMID: 17284437, PMCID: PMC2825872, DOI: 10.1074/jbc.m700746200.Peer-Reviewed Original ResearchMolecular basis for calcium signaling in hepatic stellate cells
Kruglov EA, Correa PR, Arora G, Yu J, Nathanson MH, Dranoff JA. Molecular basis for calcium signaling in hepatic stellate cells. AJP Gastrointestinal And Liver Physiology 2007, 292: g975-g982. PMID: 17204544, DOI: 10.1152/ajpgi.00401.2006.Peer-Reviewed Original ResearchMeSH KeywordsActive Transport, Cell NucleusAdenosine TriphosphateAnimalsCalcium SignalingCalreticulinCell NucleusCell ShapeCell Surface ExtensionsCells, CulturedEndoplasmic ReticulumInositol 1,4,5-Trisphosphate ReceptorsLiverLiver CirrhosisMaleMicroscopy, ConfocalMicroscopy, VideoRatsRats, Sprague-DawleyReceptors, Purinergic P2RNA, MessengerTime FactorsConceptsHepatic stellate cellsCell extensionsLipid-storing cellsSubcellular organizationLiver fibrosisMolecular basisStellate cellsSubcellular signalingTrisphosphate receptorChronic liver failureProgressive liver fibrosisSufficient machineryExtracellular ATPMyofibroblastic transdifferentiationOrgan fibrosisLiver failureP2Y receptorsHealthy liverATPLocal controlCellsCritical stepLocal applicationImportant mediatorFibrosis
2002
The type II inositol 1,4,5-trisphosphate receptor can trigger Ca2+ waves in rat hepatocytes
Hirata K, Pusl T, O'Neill AF, Dranoff JA, Nathanson MH. The type II inositol 1,4,5-trisphosphate receptor can trigger Ca2+ waves in rat hepatocytes. Gastroenterology 2002, 122: 1088-1100. PMID: 11910359, DOI: 10.1053/gast.2002.32363.Peer-Reviewed Original ResearchAdenosine Diphosphate RiboseAnimalsCalciumCalcium ChannelsCalcium SignalingCyclic ADP-RiboseGene ExpressionHemostaticsHepatocytesImage Processing, Computer-AssistedInositol 1,4,5-Trisphosphate ReceptorsIsomerismMaleMicroscopy, ConfocalRatsRats, Sprague-DawleyReceptors, Cytoplasmic and NuclearSecond Messenger SystemsVasopressins