2011
Increased Tubular Proliferation as an Adaptive Response to Glomerular Albuminuria
Guo JK, Marlier A, Shi H, Shan A, Ardito TA, Du ZP, Kashgarian M, Krause DS, Biemesderfer D, Cantley LG. Increased Tubular Proliferation as an Adaptive Response to Glomerular Albuminuria. Journal Of The American Society Of Nephrology 2011, 23: 429-437. PMID: 22193389, PMCID: PMC3294312, DOI: 10.1681/asn.2011040396.Peer-Reviewed Original ResearchMeSH KeywordsAlbuminuriaAnimalsAxl Receptor Tyrosine KinaseCell ProliferationDisease Models, AnimalFemaleHeparin-binding EGF-like Growth FactorIntegrasesIntercellular Signaling Peptides and ProteinsIntracellular Signaling Peptides and ProteinsKidney GlomerulusKidney Tubules, ProximalMaleMembrane ProteinsMiceMice, TransgenicPodocytesProteinuriaProto-Oncogene ProteinsReceptor Protein-Tyrosine KinasesConceptsGlomerular proteinuriaTubular injuryTubular proliferationStructural glomerular injuryProteinuric renal diseaseOnset of albuminuriaRenal tubular atrophyDiphtheria toxin receptorRenal tubular cellsProximal tubule cellsGlomerular albuminuriaRenal failureSystemic inflammationTubular damageProgressive glomerulosclerosisRenal diseaseTubular atrophyGlomerular injuryRenal responsePodocyte lossProliferative responseTubular cellsAnimal modelsProteinuriaReceptor Axl
2006
Prevention of mesangial sclerosis by bone marrow transplantation
Guo J, Ardito TA, Kashgarian M, Krause DS. Prevention of mesangial sclerosis by bone marrow transplantation. Kidney International 2006, 70: 910-913. PMID: 16850025, DOI: 10.1038/sj.ki.5001698.Peer-Reviewed Original ResearchConceptsBone marrow transplantationMesangial sclerosisMarrow transplantationUrinary albumin lossSimilar therapeutic effectsOnset of diseaseWild-type BMIntrarenal administrationRenal functionRenal histologyRenal diseaseDisease onsetRenal pathologyBM cellsTherapeutic effectEngraftment levelsRenal cellsAlbumin lossKidney samplesMiceSclerosisTransplantationUntreated controlsDiseaseAdministrationAn Inducible Mouse Model for PAX2-Dependent Glomerular Disease: Insights into a Complex Pathogenesis
Wagner KD, Wagner N, Guo JK, Elger M, Dallman MJ, Bugeon L, Schedl A. An Inducible Mouse Model for PAX2-Dependent Glomerular Disease: Insights into a Complex Pathogenesis. Current Biology 2006, 16: 793-800. PMID: 16631587, DOI: 10.1016/j.cub.2006.02.072.Peer-Reviewed Original ResearchConceptsInducible mouse modelGlomerular diseaseMouse modelAngiotensin-converting enzyme inhibitorEnd-stage renal failureTreatment of miceHealthy adult animalsRenal failureRenal functionRenal diseaseComplex pathogenesisNephrin expressionEnzyme inhibitorsDiseaseAdult animalsPodocytesDedifferentiated phenotypePersistent expressionMature podocytesPAX2MicePax genesFunctional relevanceTranscriptional repressorActivation
2005
Bone Marrow Transplantation Can Attenuate the Progression of Mesangial Sclerosis
Guo J, Schedl A, Krause DS. Bone Marrow Transplantation Can Attenuate the Progression of Mesangial Sclerosis. Stem Cells 2005, 24: 406-415. PMID: 16150922, DOI: 10.1634/stemcells.2005-0139.Peer-Reviewed Original ResearchConceptsBone marrow transplantationBM transplantationWild-type BMMesangial sclerosisMarrow transplantationBeneficial effectsLong-term beneficial effectsLower urinary albuminBM-derived cellsDonor BM cellsWild-type recipientsSignificant beneficial effectLong-term improvementProlongation of lifespanMaximal ameliorationRenal diseaseUrinary albuminRenal parenchymaBM cellsTherapeutic effectAlbuminuriaTransplantationTherapeutic potentialLethal doseHeterozygous mice