2001
Hepatocyte growth factor is a mitogen for olfactory ensheathing cells
Yan H, Nie X, Kocsis J. Hepatocyte growth factor is a mitogen for olfactory ensheathing cells. Journal Of Neuroscience Research 2001, 66: 698-704. PMID: 11746390, PMCID: PMC2605377, DOI: 10.1002/jnr.10009.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodiesBrain Tissue TransplantationCell DivisionCell SizeCell SurvivalCells, CulturedColforsinCulture Media, Serum-FreeCyclic AMPDose-Response Relationship, DrugDrug InteractionsFemaleGlial Fibrillary Acidic ProteinHepatocyte Growth FactorImmunohistochemistryMitogensNeurogliaOlfactory BulbProto-Oncogene Proteins c-metRatsRats, WistarReceptor, Nerve Growth FactorS100 ProteinsTrauma, Nervous SystemConceptsHepatocyte growth factorActivity of HGFAdult rat olfactory bulbHGF/c-Met systemGrowth factorOEC proliferationMitogenic activityOlfactory Ensheathing CellsRat olfactory bulbAbility of HGFC-Met receptorAddition of forskolinCultured OECsOlfactory bulbVariety of cellsDNA synthesisC-MetSerum-free mediumPotential mitogenic activityPotent mitogenMulti-functional effectsImmunocytochemical analysisCell proliferationOlfactory systemOECs
2000
Transplantation of human olfactory ensheathing cells elicits remyelination of demyelinated rat spinal cord
Kato T, Honmou O, Uede T, Hashi K, Kocsis J. Transplantation of human olfactory ensheathing cells elicits remyelination of demyelinated rat spinal cord. Glia 2000, 30: 209-218. PMID: 10756071, PMCID: PMC2605375, DOI: 10.1002/(sici)1098-1136(200005)30:3<209::aid-glia1>3.0.co;2-8.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCation Transport ProteinsCell SizeCells, CulturedDemyelinating DiseasesDNA ProbesFemaleFungal ProteinsHumansIn Situ HybridizationMembrane Transport ProteinsMicroscopy, ElectronMiddle AgedMyelin SheathNeurogliaOlfactory NerveRatsRats, WistarSaccharomyces cerevisiae ProteinsSpinal CordConceptsSpinal cordDemyelinated rat spinal cordHuman olfactoryImmunosuppressed adult ratsDemyelinated spinal cordAdult mammalian CNSRat spinal cordExtensive remyelinationHuman OECsDemyelinated axonsOlfactory nervePeripheral typeSchwann cellsAdult ratsLesion siteMammalian CNSMyelin sheathRemyelinationCordAxonsSitu hybridizationSimilar numberOlfactoryCellsLarge nuclei
1998
Mechanisms of enhancement of neurite regeneration in vitro following a conditioning sciatic nerve lesion
Lankford K, Waxman S, Kocsis J. Mechanisms of enhancement of neurite regeneration in vitro following a conditioning sciatic nerve lesion. The Journal Of Comparative Neurology 1998, 391: 11-29. PMID: 9527536, PMCID: PMC2605358, DOI: 10.1002/(sici)1096-9861(19980202)391:1<11::aid-cne2>3.0.co;2-u.Peer-Reviewed Original ResearchConceptsDorsal root gangliaConditioning lesionNerve injuryNerve regenerationAffected dorsal root ganglionControl dorsal root gangliaDenervated peripheral nervePrior nerve injurySciatic nerve lesionCultured DRG neuronsSciatic nerve transectionPeripheral target tissuesPeripheral nerve stumpRapid nerve regenerationAbility of neuronsSecond axotomyNerve lesionsDRG neuronsNerve transectionNerve stumpRoot gangliaControl neuronsPeripheral nervesNerve tractsAdult rats