2000
Voltage-Gated Calcium Currents in Axotomized Adult Rat Cutaneous Afferent Neurons
Baccei M, Kocsis J. Voltage-Gated Calcium Currents in Axotomized Adult Rat Cutaneous Afferent Neurons. Journal Of Neurophysiology 2000, 83: 2227-2238. PMID: 10758131, DOI: 10.1152/jn.2000.83.4.2227.Peer-Reviewed Original ResearchConceptsVoltage-gated calcium currentsCutaneous afferent neuronsPA/pFNerve injuryCutaneous afferentsType 1 cellsBarium currentsAfferent neuronsHVA currentsCalcium currentLow threshold T-type currentWhole-cell patch-clamp techniqueDorsal root ganglion neuronsCell patch-clamp techniqueFluoro-Gold labelingOmega-agatoxin TKSciatic nerve injuryOmega-conotoxin GVIAPercentage of neuronsType 2 phenotypeT-type currentType 2 neuronsCalcium current propertiesType 1 neuronsControl cells
1998
Peripheral Axotomy Induces Long-Term c-Jun Amino-Terminal Kinase-1 Activation and Activator Protein-1 Binding Activity by c-Jun and junD in Adult Rat Dorsal Root Ganglia In Vivo
Kenney A, Kocsis J. Peripheral Axotomy Induces Long-Term c-Jun Amino-Terminal Kinase-1 Activation and Activator Protein-1 Binding Activity by c-Jun and junD in Adult Rat Dorsal Root Ganglia In Vivo. Journal Of Neuroscience 1998, 18: 1318-1328. PMID: 9454841, PMCID: PMC2605350, DOI: 10.1523/jneurosci.18-04-01318.1998.Peer-Reviewed Original ResearchConceptsC-Jun proteinC-JunC-Jun amino-terminal kinase 1Nerve injuryAxonal regenerationAmino-terminal phosphorylationLumbar dorsal root ganglion neuronsActivator protein-1 bindingEarly post-injury periodJun kinase activationAdult rat dorsal root gangliaDorsal root ganglion neuronsRat dorsal root gangliaKinase 1 activationC-Jun phosphorylationSciatic nerve injuryActivator protein-1 binding activityPost-injury periodSciatic nerve transectionAdult rat DRGDorsal root gangliaLong-term upregulationPeripheral axonal regenerationAP-1 bindingProtein-1 binding
1997
Timing of c-jun protein induction in lumbar dorsal root ganglia after sciatic nerve transection varies with lesion distance
Kenney A, Kocsis J. Timing of c-jun protein induction in lumbar dorsal root ganglia after sciatic nerve transection varies with lesion distance. Brain Research 1997, 751: 90-95. PMID: 9098571, DOI: 10.1016/s0006-8993(96)01402-3.Peer-Reviewed Original ResearchConceptsSciatic nerve transectionNerve transectionDorsal root gangliaNerve injuryRoot gangliaLumbar dorsal root ganglion neuronsL5 dorsal root gangliaLumbar dorsal root gangliaDorsal root ganglion neuronsSciatic nerve injurySciatic nerve crushC-Jun proteinProtein inductionC-Jun responseNerve crushGanglion neuronsImmunohistochemical studyLesion distanceTransectionInduces upregulationEarly increaseC-jun mRNAEarly inductionChemiluminescent immunoblottingGanglia
1993
Increased spike‐frequency adaptation and tea sensitivity in dorsal root fibers after sciatic nerve injury
Utzschneider D, Bhisitkhul R, Kocsis J. Increased spike‐frequency adaptation and tea sensitivity in dorsal root fibers after sciatic nerve injury. Muscle & Nerve 1993, 16: 958-963. PMID: 8355727, DOI: 10.1002/mus.880160912.Peer-Reviewed Original ResearchConceptsCompound action potentialDorsal root axonsNerve injuryDorsal rootsPotassium channel blockerAction potentialsSciatic nerveChannel blockersSpike adaptationSciatic nerve injuryPeripheral nerve injurySucrose gap chamberBrief tetanic stimulationDorsal root fibersWhole nerve recordingsSpike frequency adaptationTransection groupBurst dischargesTetanic stimulationNerve recordingsControl groupInjuryRoot fibersBurst responseNerve