A summary of mechanistic hypotheses of gabapentin pharmacology
Taylor C, Gee N, Su T, Kocsis J, Welty D, Brown J, Dooley D, Boden P, Singh L. A summary of mechanistic hypotheses of gabapentin pharmacology. Epilepsy Research 1998, 29: 233-249. PMID: 9551785, DOI: 10.1016/s0920-1211(97)00084-3.Peer-Reviewed Original ResearchConceptsAmyotrophic lateral sclerosisNon-vesicular GABA releaseCellular mechanismsVoltage-sensitive Ca2Specific amino acid transportersGabapentin bindsGABA releaseNeuronal deathElectrophysiology resultsAnticonvulsant drugsLateral sclerosisNeuroprotective activityNeurobehavioral actionsPharmacological actionsGabapentinAnimal modelsHuman whole bloodBrain tissueMonoamine neurotransmittersAmino acid transportersWhole bloodAcid transportersAuxiliary subunitsPharmacologyRate of synthesis
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