2001
Transplantation of Cryopreserved Adult Human Schwann Cells Enhances Axonal Conduction in Demyelinated Spinal Cord
Kohama I, Lankford K, Preiningerova J, White F, Vollmer T, Kocsis J. Transplantation of Cryopreserved Adult Human Schwann Cells Enhances Axonal Conduction in Demyelinated Spinal Cord. Journal Of Neuroscience 2001, 21: 944-950. PMID: 11157080, PMCID: PMC2605383, DOI: 10.1523/jneurosci.21-03-00944.2001.Peer-Reviewed Original ResearchConceptsHuman Schwann cellsSchwann cellsDorsal columnsSural nerveAxonal conductionIntra-axonal recording techniquesDorsal column lesionLegs of patientsDemyelinated spinal cordHuman sural nerveAdult human Schwann cellsFunctional remyelinationExtensive remyelinationCell-based therapiesMultiple sclerosisVascular diseaseSpinal cordWistar ratsConduction blockAdult CNSConduction velocityLesion zoneAction potentialsMonoclonal antibodiesLesions
2000
[Characteristic improvement of the function following Schwann cell transplantation for demyelinated spinal cord].
Imaizumi T, Lankford K, Kocsis J, Honmou O, Kohama I, Hashi K. [Characteristic improvement of the function following Schwann cell transplantation for demyelinated spinal cord]. No Shinkei Geka. Neurological Surgery 2000, 28: 705-11. PMID: 11002493.Peer-Reviewed Original ResearchConceptsCompound action potentialDorsal rootsSchwann cellsSC transplantationSC myelinationAdult ratsConduction velocityTransplantation of SCsNormal DCsDorsal root ganglion neuronsDorsal column axonsLower conduction velocityGanglion neuronsSpinal cordDemyelinated axonsHistological examinationTransplantationAction potentialsRemyelinationAxonsOligodendrocytesRatsMyelinationAnatomical differencesLow amplitude[Comparison of myelin-forming cells as candidates for therapeutic transplantation in demyelinated CNS axons].
Imaizumi T, Lankford K, Kocsis J, Sasaki M, Akiyama Y, Hashi K. [Comparison of myelin-forming cells as candidates for therapeutic transplantation in demyelinated CNS axons]. Brain And Nerve 脳と神経 2000, 52: 609-15. PMID: 10934721.Peer-Reviewed Original ResearchConceptsDemyelinated CNS axonsSchwann cellsBrain cellsSpinal cordConduction velocityCNS axonsAdult rat spinal cordFronto-temporal lobesRat spinal cordAdult Schwann cellsDemyelination of axonsMyelin-forming cellsBlock of conductionAdult olfactoryDemyelinated diseasesDemyelinated axonsLess myelinationHistological examinationCNS tissueTherapeutic approachesStimulus trainsDay 28Transplanted OECsAmplitude decrementRemyelination
1998
Transplanted Olfactory Ensheathing Cells Remyelinate and Enhance Axonal Conduction in the Demyelinated Dorsal Columns of the Rat Spinal Cord
Imaizumi T, Lankford K, Waxman S, Greer C, Kocsis J. Transplanted Olfactory Ensheathing Cells Remyelinate and Enhance Axonal Conduction in the Demyelinated Dorsal Columns of the Rat Spinal Cord. Journal Of Neuroscience 1998, 18: 6176-6185. PMID: 9698311, PMCID: PMC2605360, DOI: 10.1523/jneurosci.18-16-06176.1998.Peer-Reviewed Original ResearchConceptsDorsal column axonsRat spinal cordSpinal cordRemyelinated axonsDorsal columnsAdult rat spinal cordExtent of remyelinationTransplantation of OECsSpinal cord lesionsCell injection siteQuantitative histological analysisFunctional remyelinationCord lesionsAxonal conductionNeonatal ratsFocal injectionsConduction blockSchwann cellsConduction velocityInjection siteElectrophysiological propertiesAction potentialsAxonsHistological analysisTransplantation
1997
Functional Repair of Myelinated Fibers in the Spinal Cord by Transplantation of Glial Cells
Waxman S, Kocsis J. Functional Repair of Myelinated Fibers in the Spinal Cord by Transplantation of Glial Cells. Altschul Symposia Series 1997, 283-298. DOI: 10.1007/978-1-4615-5949-8_28.Peer-Reviewed Original ResearchConduction velocityMyelinated axonsMyelin sheathNon-myelinated fibresClinical deficitsMyelin damageConduction abnormalitiesDemyelinated axonsSpinal cordGlial cellsMyelinated fibersConduction blockSynaptic terminalsAction potentialsRefractory periodCell bodiesDemyelinated fibersAxonsFunctional repair
1992
Conduction properties of spinal cord axons in the myelin-deficient rat mutant
Utzschneider D, Black J, Kocsis J. Conduction properties of spinal cord axons in the myelin-deficient rat mutant. Neuroscience 1992, 49: 221-228. PMID: 1407548, DOI: 10.1016/0306-4522(92)90090-o.Peer-Reviewed Original ResearchConceptsDorsal column axonsMyelin-deficient rat mutantsSpinal cordFrequency-dependent conduction blockNormal age-matched ratsBrain slice chamberMyelin-deficient rat spinal cordAction potential dischargeRat mutantAge-matched ratsRat spinal cordSpinal cord axonsAction potential conductionControl ratsDemyelinated axonsConduction blockConduction velocityRefractory periodPotential dischargeControl axonsSlice chamberPharmacological resultsPotential conductionAxonsCompensatory mechanisms
1988
Buspirone, 8-OH-DPAT and ipsapirone: effects on hippocampal cerebellar and sciatic fiber excitability
Hiner B, Mauk M, Peroutka S, Kocsis J. Buspirone, 8-OH-DPAT and ipsapirone: effects on hippocampal cerebellar and sciatic fiber excitability. Brain Research 1988, 461: 1-9. PMID: 2906267, DOI: 10.1016/0006-8993(88)90719-6.Peer-Reviewed Original ResearchConceptsCerebellar parallel fibersSerotonergic mechanismsNerve excitabilityFiber excitabilityAction potentialsSucrose gap recordingsEffects of serotoninNovel anxiolytic buspironeCompound action potentialDose-dependent reductionSchaffer collateral fibersParallel fibersAfferent fibersSciatic nerveReversible decrementsCollateral fibersAnxiolytic buspironeConduction velocityDPATIpsapironeGap recordingsBuspironeCerebellar neuronsAxonal responseExcitability
1987
Activity-evoked increases in extracellular potassium modulate presynaptic excitability in the CA1 region of the hippocampus
Poolos N, Mauk M, Kocsis J. Activity-evoked increases in extracellular potassium modulate presynaptic excitability in the CA1 region of the hippocampus. Journal Of Neurophysiology 1987, 58: 404-416. PMID: 3655875, DOI: 10.1152/jn.1987.58.2.404.Peer-Reviewed Original ResearchConceptsEnd of stimulationConduction velocityRepetitive stimulationCA1 afferentsStratum radiatumCA1 regionPostsynaptic elementsPostsynaptic activityBiphasic changeRat hippocampal slice preparationCompound action potentialHippocampal slice preparationCharacteristic field potentialHigher stimulation frequenciesPostsynaptic modulationPresynaptic volleyKynurenic acidPyramidal cellsSlice preparationPresynaptic axonsPresynaptic excitabilitySynaptic transmissionConduction blockIon-sensitive microelectrodesPostsynaptic activation
1979
Variation in conduction velocity during the relative refractory and supernormal periods: A mechanism for impulse entrainment in central axons
Kocsis J, Swadlow H, Waxman S, Brill M. Variation in conduction velocity during the relative refractory and supernormal periods: A mechanism for impulse entrainment in central axons. Experimental Neurology 1979, 65: 230-236. PMID: 262231, DOI: 10.1016/0014-4886(79)90263-2.Peer-Reviewed Original ResearchA supernormal period in central axons following single cell stimulation
Kocsis J, VanderMaelen C. A supernormal period in central axons following single cell stimulation. Experimental Brain Research 1979, 36: 381-386. PMID: 488207, DOI: 10.1007/bf00238919.Peer-Reviewed Original Research