2001
[The role of transplanted astrocytes for the regeneration of CNS axons].
Imaizumi T, Lankford K, Kocsis J, Hashi K. [The role of transplanted astrocytes for the regeneration of CNS axons]. Brain And Nerve 脳と神経 2001, 53: 632-8. PMID: 11517487.Peer-Reviewed Original ResearchConceptsCompound action potentialRegenerated axonsSC transplantationAxonal regenerationAdult ratsLong-tract axonsMyelin associated proteinsDorsal column axonsRegeneration of axonsDC axonsCell transplantationDorsal rootsNeonatal ratsSpinal cordReduction of scarsHistological examinationTransplantationMammalian CNSCNS axonsAction potentialsAxonsMyelin formationLesionsThree daysRats
2000
[Characteristic improvement of the function following Schwann cell transplantation for demyelinated spinal cord].
Imaizumi T, Lankford K, Kocsis J, Honmou O, Kohama I, Hashi K. [Characteristic improvement of the function following Schwann cell transplantation for demyelinated spinal cord]. No Shinkei Geka. Neurological Surgery 2000, 28: 705-11. PMID: 11002493.Peer-Reviewed Original ResearchConceptsCompound action potentialDorsal rootsSchwann cellsSC transplantationSC myelinationAdult ratsConduction velocityTransplantation of SCsNormal DCsDorsal root ganglion neuronsDorsal column axonsLower conduction velocityGanglion neuronsSpinal cordDemyelinated axonsHistological examinationTransplantationAction potentialsRemyelinationAxonsOligodendrocytesRatsMyelinationAnatomical differencesLow amplitude
1998
Resistance to anoxic injury in the dorsal columns of adult rat spinal cord following demyelination
Imaizumi T, Kocsis J, Waxman S. Resistance to anoxic injury in the dorsal columns of adult rat spinal cord following demyelination. Brain Research 1998, 779: 292-296. PMID: 9473700, DOI: 10.1016/s0006-8993(97)01171-2.Peer-Reviewed Original ResearchConceptsCompound action potentialDorsal columnsSpinal cordAction potentialsWhite matterSpinal cord dorsal columnAdult rat spinal cordAdult spinal cordRat spinal cordMin of reoxygenationAdult white matterAction potential conductionControl ratsFocal demyelinationAnoxic injurySupramaximal stimulationOnset of anoxiaAdult ratsDemyelinationPotential conductionCordX-irradiationRatsGreater recoveryOnset
1993
Increased spike‐frequency adaptation and tea sensitivity in dorsal root fibers after sciatic nerve injury
Utzschneider D, Bhisitkhul R, Kocsis J. Increased spike‐frequency adaptation and tea sensitivity in dorsal root fibers after sciatic nerve injury. Muscle & Nerve 1993, 16: 958-963. PMID: 8355727, DOI: 10.1002/mus.880160912.Peer-Reviewed Original ResearchConceptsCompound action potentialDorsal root axonsNerve injuryDorsal rootsPotassium channel blockerAction potentialsSciatic nerveChannel blockersSpike adaptationSciatic nerve injuryPeripheral nerve injurySucrose gap chamberBrief tetanic stimulationDorsal root fibersWhole nerve recordingsSpike frequency adaptationTransection groupBurst dischargesTetanic stimulationNerve recordingsControl groupInjuryRoot fibersBurst responseNerve
1991
Tea‐sensitive potassium channels and inward rectification in regenerated rat sciatic nerve
Gardon T, Kocsis J, Waxman S. Tea‐sensitive potassium channels and inward rectification in regenerated rat sciatic nerve. Muscle & Nerve 1991, 14: 640-646. PMID: 1922170, DOI: 10.1002/mus.880140707.Peer-Reviewed Original ResearchConceptsCompound action potentialRat sciatic nerveNerve crushRegenerated axonsSciatic nerveRegenerated nervesInward rectificationIntra-axonal recording techniquesAdult rat sciatic nerveTEA-sensitive potassium channelsPotassium channelsRegenerated rat sciatic nerveSucrose gap recordingsSciatic nerve crushPeripheral nerve axonsWhole nerve recordingsIntra-axonal recordingsVoltage-sensitive sodium channelsCrush injuryNormal nervesSensitive relaxationRepetitive stimulationAfterhyperpolarizationGap recordingsNerve recordingsDifferential sensitivity to hypoxia of the peripheral versus central trajectory of primary afferent axons
Utzschneider D, Kocsis J, Waxman S. Differential sensitivity to hypoxia of the peripheral versus central trajectory of primary afferent axons. Brain Research 1991, 551: 136-141. PMID: 1913145, DOI: 10.1016/0006-8993(91)90924-k.Peer-Reviewed Original ResearchConceptsDorsal columnsDorsal rootsAfferent fibersCentral nervous system componentsPrimary afferent fibersSucrose gap chamberAction potential amplitudePrimary afferent axonsCompound action potentialDorsal spinal rootsNervous system componentsAxonal trunksPeripheral nervesSpinal cordSpinal rootsAfferent axonsCNS portionSchwann cellsAdult ratsPotential amplitudeAxon branchesAction potentialsHypoxiaMembrane potential changesMembrane depolarization
1988
Buspirone, 8-OH-DPAT and ipsapirone: effects on hippocampal cerebellar and sciatic fiber excitability
Hiner B, Mauk M, Peroutka S, Kocsis J. Buspirone, 8-OH-DPAT and ipsapirone: effects on hippocampal cerebellar and sciatic fiber excitability. Brain Research 1988, 461: 1-9. PMID: 2906267, DOI: 10.1016/0006-8993(88)90719-6.Peer-Reviewed Original ResearchConceptsCerebellar parallel fibersSerotonergic mechanismsNerve excitabilityFiber excitabilityAction potentialsSucrose gap recordingsEffects of serotoninNovel anxiolytic buspironeCompound action potentialDose-dependent reductionSchaffer collateral fibersParallel fibersAfferent fibersSciatic nerveReversible decrementsCollateral fibersAnxiolytic buspironeConduction velocityDPATIpsapironeGap recordingsBuspironeCerebellar neuronsAxonal responseExcitabilityDiminished dorsal root GABA sensitivity following chronic peripheral nerve injury
Kingery W, Fields R, Kocsis J. Diminished dorsal root GABA sensitivity following chronic peripheral nerve injury. Experimental Neurology 1988, 100: 478-490. PMID: 3366201, DOI: 10.1016/0014-4886(88)90033-7.Peer-Reviewed Original ResearchConceptsGamma-aminobutyric acidPrimary afferent depolarizationDorsal rootsGABA sensitivityNerve lesionsSciatic nerveDorsal root compound action potentialsChronic peripheral nerve injurySciatic crush injurySciatic nerve lesionChronic pain syndromeLumbar dorsal rootsPeripheral nerve injuryPeripheral nerve lesionsPeripheral nerve transectionSucrose gap chamberCompound action potentialDorsal root fibersRat lumbar dorsal rootsDorsal root axotomyPain syndromeNerve injuryCrush injuryNerve transectionSciatic axotomy
1987
Physiological effects of 4‐aminopyridine on demyelinated mammalian motor and sensory fibers
Bowe C, Kocsis J, Targ E, Waxman S. Physiological effects of 4‐aminopyridine on demyelinated mammalian motor and sensory fibers. Annals Of Neurology 1987, 22: 264-268. PMID: 2821876, DOI: 10.1002/ana.410220212.Peer-Reviewed Original ResearchConceptsSensory fibersClinical trialsAction potentialsPotassium channel blockadeDorsal root axonsCompound action potentialDorsal spinal rootsSingle action potentialMammalian motorIntrathecal injectionMultiple sclerosisSensory dysfunctionVentral rootsSpinal rootsNeuromuscular disordersSpecific fiber typesElectrophysiological responsesSingle stimulusPhysiological effectsTrialsFiber typesResponseParesthesiaSclerosisDysfunctionActivity-evoked increases in extracellular potassium modulate presynaptic excitability in the CA1 region of the hippocampus
Poolos N, Mauk M, Kocsis J. Activity-evoked increases in extracellular potassium modulate presynaptic excitability in the CA1 region of the hippocampus. Journal Of Neurophysiology 1987, 58: 404-416. PMID: 3655875, DOI: 10.1152/jn.1987.58.2.404.Peer-Reviewed Original ResearchConceptsEnd of stimulationConduction velocityRepetitive stimulationCA1 afferentsStratum radiatumCA1 regionPostsynaptic elementsPostsynaptic activityBiphasic changeRat hippocampal slice preparationCompound action potentialHippocampal slice preparationCharacteristic field potentialHigher stimulation frequenciesPostsynaptic modulationPresynaptic volleyKynurenic acidPyramidal cellsSlice preparationPresynaptic axonsPresynaptic excitabilitySynaptic transmissionConduction blockIon-sensitive microelectrodesPostsynaptic activationPhysiological properties of regenerated rat sciatic nerve following lesions at different postnatal ages
Bowe C, Kocsis J, Waxman S, Hildebrand C. Physiological properties of regenerated rat sciatic nerve following lesions at different postnatal ages. Brain Research 1987, 34: 123-131. DOI: 10.1016/0165-3806(87)90201-x.Peer-Reviewed Original ResearchControl nervesPostnatal ageSciatic nerveRegenerated nervesRegenerated rat sciatic nerveFrequency-following abilityOlder postnatal ageSciatic crush lesionRegenerated sciatic nerveAge 3 weeksCompound action potentialDifferent postnatal agesRat sciatic nerveWhole-nerve responseMonths of ageRelative refractory periodCrush lesionPharmacological blockadeNerve responsesSlight prolongationNerveElectrophysiological propertiesAction potentialsRefractory periodOlder age
1986
Action potential characteristics of demyelinated rat sciatic nerve following application of 4-aminopyridine
Targ E, Kocsis J. Action potential characteristics of demyelinated rat sciatic nerve following application of 4-aminopyridine. Brain Research 1986, 363: 1-9. PMID: 3004637, DOI: 10.1016/0006-8993(86)90652-9.Peer-Reviewed Original ResearchConceptsAction potentialsSciatic nerveFrequency-following abilityMultiple spike dischargesSite of demyelinationCompound action potentialPotassium channel blockerRat sciatic nerveAction potential characteristicsVariety of abnormalitiesAbsolute refractory periodExcitability changesPharmacological blockadeSpontaneous firingDemyelinated axonsChannel blockersConduction slowingConduction blockSpike dischargesLesion siteRefractory periodExcitability propertiesClinical useAxonsPotassium channels
1985
Differences between mammalian ventral and dorsal spinal roots in response to blockade of potassium channels during maturation
Bowe C, Kocsis J, Waxman S. Differences between mammalian ventral and dorsal spinal roots in response to blockade of potassium channels during maturation. Proceedings Of The Royal Society B 1985, 224: 355-366. PMID: 2410932, DOI: 10.1098/rspb.1985.0037.Peer-Reviewed Original ResearchConceptsDorsal spinal rootsSensory fibersMammalian motorPotassium channelsSpinal rootsAction potentialsRoot fibersCompound action potentialSingle sensory fibresDorsal root fibersVentral root fibersClasses of axonsIndividual action potentialsPharmacological blockadeVentral rootsYoung rootsSensory axonsWhole nervePotassium conductanceAxon responsesCourse of maturationBlockadeAxonsRoots resultsDifferential sensitivityLigature‐induced injury in peripheral nerve: Electrophysiological observations on changes in action potential characteristics following blockade of potassium conductance
Waxman S, Kocsis J, Eng D. Ligature‐induced injury in peripheral nerve: Electrophysiological observations on changes in action potential characteristics following blockade of potassium conductance. Muscle & Nerve 1985, 8: 85-92. PMID: 2414652, DOI: 10.1002/mus.880080202.Peer-Reviewed Original ResearchConceptsAction potentialsRepetitive firingSingle stimulusPotassium channelsCompound action potentialRat sciatic nerveAction potential propertiesWhole-nerve responseAction potential characteristicsIntra-axonal recordingsAction potential waveformNerve segmentsSciatic nerveNerve responsesPeripheral nervesInjury siteMyelinated fibersLater spikesElectrophysiological observationsNerveRefractory periodFiring patternsPotassium conductancePotential waveformInitial spikeAminopyridine-sensitivity of spinal cord white matter studied in vitro
Kocsis J. Aminopyridine-sensitivity of spinal cord white matter studied in vitro. Experimental Brain Research 1985, 57: 620-624. PMID: 2984039, DOI: 10.1007/bf00237849.Peer-Reviewed Original ResearchConceptsCentral nervous system extensionSpinal cord white matterAction potential dischargeDorsal column axonsSucrose gap chamberCompound action potentialPeripheral nervous systemCord white matterVentral root fibersAction potential characteristicsSensory fibersDorsal columnsDorsal rootsSpinal cordNervous systemWhite matterAction potentialsPotential dischargeRoot fibersPotassium channelsCourse of maturationOcclusion experimentsAxonsPronounced increaseCord
1982
Regenerating mammalian nerve fibres: changes in action potential waveform and firing characteristics following blockage of potassium conductance
Kocsis J, Waxman S, Hildebrand C, Ruiz J. Regenerating mammalian nerve fibres: changes in action potential waveform and firing characteristics following blockage of potassium conductance. Proceedings Of The Royal Society B 1982, 217: 77-87. PMID: 6131423, DOI: 10.1098/rspb.1982.0095.Peer-Reviewed Original ResearchConceptsRegenerating axonsNerve fibersFiring propertiesAction potentialsPotassium conductancePotassium channelsCompound action potentialSciatic nerve fibersEarly regenerating axonsAction potential waveformRat nerve fibresMammalian nerve fibresDemyelinated axonsMyelinated fibersExtracellular applicationAxonsRecording techniquesSingle stimulusFiring characteristicsPotential waveformPresent study