2020
Hormonal Regulation of Cholangiocyte Secretion
Gigliozzi A, Fraioli F, Boyer J. Hormonal Regulation of Cholangiocyte Secretion. 2020, 89-95. DOI: 10.1201/9780367813888-8.Peer-Reviewed Original ResearchVasoactive intestinal peptideCholangiocyte secretionBicarbonate secretionBicarbonate-rich choleresisPost-prandial phaseExert inhibitory effectsCGMP-independent pathwayBicarbonate excretionIntestinal peptideParasympathetic systemPKA-dependent pathwayHepatic bileCholangiocyte proliferationActivation of calcineurinMaximal stimulationInhibitory effectSecretionBicarbonate requirementEnhanced expressionAdenylyl cyclaseHormonal regulationDigestive functionMajor determinantActivationCorticosteroids
2002
Mechanisms of Hepatic Transport of Drugs: Implications for Cholestatic Drug Reactions
Bohan A, Boyer J. Mechanisms of Hepatic Transport of Drugs: Implications for Cholestatic Drug Reactions. Seminars In Liver Disease 2002, 22: 123-136. PMID: 12016544, DOI: 10.1055/s-2002-30099.Peer-Reviewed Original ResearchConceptsDrug-induced cholestasisCholestatic drug reactionDrug reactionsDrug transporter expressionNumber of drugsBiliary excretionCanalicular transport proteinsAnimal modelsHepatic uptakeHepatobiliary transportersCholestasisTransporter expressionHepatic transportGenetic polymorphismsNormal functionDrugsMajor determinantForeign compoundsStudy of mechanismsTransportersExcretion