2018
Solute Carrier Organic Anion Transporter Family Member 3A1 Is a Bile Acid Efflux Transporter in Cholestasis
Pan Q, Zhang X, Zhang L, Cheng Y, Zhao N, Li F, Zhou X, Chen S, Li J, Xu S, Huang D, Chen Y, Li L, Wang H, Chen W, Cai SY, Boyer JL, Chai J. Solute Carrier Organic Anion Transporter Family Member 3A1 Is a Bile Acid Efflux Transporter in Cholestasis. Gastroenterology 2018, 155: 1578-1592.e16. PMID: 30063921, PMCID: PMC6221191, DOI: 10.1053/j.gastro.2018.07.031.Peer-Reviewed Original ResearchConceptsBile duct ligationLiver tissueBile acidsHepatic levelsHepatoma cell lineFibroblast growth factor 19Cholestatic liver tissuesEfflux transportersCholic acid dietDevelopment of cholestasisGrowth factor 19Sprague-Dawley ratsShorter survival timeBile acid homeostasisHealthy liver tissueReal-time quantitative polymerase chain reactionNuclear factor κBCell linesQuantitative polymerase chain reactionHuman primary hepatocytesMessenger RNALiver injuryCa dietControl miceC57BL/6J mice
1993
Phylogenic and ontogenic expression of hepatocellular bile acid transport.
Boyer J, Hagenbuch B, Ananthanarayanan M, Suchy F, Stieger B, Meier P. Phylogenic and ontogenic expression of hepatocellular bile acid transport. Proceedings Of The National Academy Of Sciences Of The United States Of America 1993, 90: 435-438. PMID: 8421672, PMCID: PMC45677, DOI: 10.1073/pnas.90.2.435.Peer-Reviewed Original ResearchConceptsAcid transportMammalian speciesFull-length cDNA probeDependent bile acid transportMammalian fetal developmentAcid cotransport systemVertebrate evolutionBile acid transportOntogenic expressionLower vertebratesNonmammalian speciesPrior functional studiesHepatoma cell lineNorthern analysisAcid transportersDedifferentiated hepatocytesCDNA probeTransport systemAcid cotransporterFunctional studiesXenopus oocytesSmall skateSpeciesMRNACell lines