2012
In Vivo Imaging of Cerebral Microvascular Plasticity from Birth to Death
Harb R, Whiteus C, Freitas C, Grutzendler J. In Vivo Imaging of Cerebral Microvascular Plasticity from Birth to Death. Cerebrovascular And Brain Metabolism Reviews 2012, 33: 146-156. PMID: 23093067, PMCID: PMC3597363, DOI: 10.1038/jcbfm.2012.152.Peer-Reviewed Original ResearchConceptsVascular stabilityYoung adult miceFirst postnatal monthDegenerative neurological disordersVessel formationHypoxia-induced angiogenesisCerebral functionPostnatal monthAdult brainAdult miceIntact brainMicrovascular plasticityNeurological disordersFirst monthMicrovessel formationOlder adultsMetabolic challengesTwo-photon microscopyNew vesselsBaseline turnoverLong-term adaptive responsesIndividual microvesselsMiceVivo patternBrain
2004
Age‐associated synapse elimination in mouse parasympathetic ganglia
Coggan JS, Grutzendler J, Bishop DL, Cook MR, Gan W, Heym J, Lichtman JW. Age‐associated synapse elimination in mouse parasympathetic ganglia. Developmental Neurobiology 2004, 60: 214-226. PMID: 15266652, DOI: 10.1002/neu.20022.Peer-Reviewed Original ResearchConceptsSynapse eliminationExcitatory postsynaptic potential amplitudeSubmandibular ganglion neuronsPostsynaptic potential amplitudeNumber of synapsesMonths of ageMammalian nervous systemAge-related changesMiniature EPSPsSMG neuronsSynapse efficacyParasympathetic gangliaGanglion neuronsEPSP amplitudeSynaptic contactsSynaptic transmissionSynaptic inputsAged animalsPotential amplitudeNervous systemSynaptic boutonsAxonal processesNeuronsOld animalsPostsynaptic membrane