Featured Publications
Lifelong cortical myelin plasticity and age-related degeneration in the live mammalian brain
Hill RA, Li AM, Grutzendler J. Lifelong cortical myelin plasticity and age-related degeneration in the live mammalian brain. Nature Neuroscience 2018, 21: 683-695. PMID: 29556031, PMCID: PMC5920745, DOI: 10.1038/s41593-018-0120-6.Peer-Reviewed Original ResearchConceptsMyelin degenerationYears of ageAge-related degenerationMyelin plasticityMyelin remodelingNeural processing speedBrain pathogenesisOligodendrocyte deathUnmyelinated axonsAxonal myelinMyelin coverageStructural remodelingMouse cortexMammalian brainPeak myelinationOligodendrocyte generationIndividual axonsMyelinating oligodendrocytesMyelin distributionDegenerationMyelin internodesNetwork homeostasisAxonsStructural plasticityRemodeling
2006
Two-photon imaging of synaptic plasticity and pathology in the living mouse brain
Grutzendler J, Gan WB. Two-photon imaging of synaptic plasticity and pathology in the living mouse brain. Neurotherapeutics 2006, 3: 489-496. PMID: 17012063, PMCID: PMC3593400, DOI: 10.1016/j.nurx.2006.07.005.Peer-Reviewed Original ResearchConceptsTwo-photon microscopyMouse brainAcute brain injuryPostsynaptic dendritic spinesAdult mouse brainCerebral ischemiaSynaptic pathologyCerebrovascular diseaseBrain injuryMouse modelDendritic spinesAnimal modelsBrain cellsIntact brainTwo-photon imagingNeuronal connectionsSynaptic plasticityAlzheimer's diseaseNeuronal structuresDiseaseBrainStructural plasticityPathologyTechnical considerationsIschemia
2000
Multicolor “DiOlistic” Labeling of the Nervous System Using Lipophilic Dye Combinations
Gan W, Grutzendler J, Wong W, Wong R, Lichtman J. Multicolor “DiOlistic” Labeling of the Nervous System Using Lipophilic Dye Combinations. Neuron 2000, 27: 219-225. PMID: 10985343, DOI: 10.1016/s0896-6273(00)00031-3.Peer-Reviewed Original ResearchConceptsNervous systemGolgi-like labelingNormal synaptic responsesComplex neuronal networksDendritic remodelingSynaptic responsesNeuronal preparationsNeuronal connectivityNeuronal circuitsIndividual neuronsNeuronsDye-coated particlesGene gunNeuronal networksStructural plasticityLipophilic dyeCellsGliaDiOlisticsLabeling