Featured Publications
ATP mediates rapid microglial response to local brain injury in vivo
Davalos D, Grutzendler J, Yang G, Kim JV, Zuo Y, Jung S, Littman DR, Dustin ML, Gan WB. ATP mediates rapid microglial response to local brain injury in vivo. Nature Neuroscience 2005, 8: 752-758. PMID: 15895084, DOI: 10.1038/nn1472.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphateAnimalsApyraseAstrocytesBrainBrain InjuriesCell CommunicationChemotaxisConnexinsGliosisGreen Fluorescent ProteinsMiceMice, TransgenicMicrogliaPhagocytosisPurinergic P2 Receptor AntagonistsReaction TimeReceptors, Purinergic P2Receptors, Purinergic P2Y1Signal TransductionConceptsRapid microglial responseMicroglial processesMicroglial responseBrain injuryG protein-coupled purinergic receptorsLocal brain injuryTraumatic brain injurySite of injuryPrincipal immune cellsPresence of apyraseParenchymal microgliaImmune cellsLocal injectionPurinergic receptorsBaseline motilityIntact brainTwo-photon imagingChannel inhibitorsMouse cortexInjuryExtracellular ATPMicrogliaEnzyme apyraseAstrocytesChemotactic response
2018
Activation of pial and dural macrophages and dendritic cells by cortical spreading depression
Schain AJ, Melo‐Carrillo A, Borsook D, Grutzendler J, Strassman AM, Burstein R. Activation of pial and dural macrophages and dendritic cells by cortical spreading depression. Annals Of Neurology 2018, 83: 508-521. PMID: 29394508, PMCID: PMC5965700, DOI: 10.1002/ana.25169.Peer-Reviewed Original ResearchConceptsBlood-brain barrierDendritic cellsDural macrophagesImmune cellsAnatomical relationshipMigratory dendritic cellsAnn NeurolTRPV1 axonsMeningeal nociceptorsHead painMigraine attacksNociceptor activationSubarachnoid spaceMeningeal macrophagesMacrophagesCortical eventsAxonsActivationAuraDuraDepressionMinutesCellsCellular eventsCSD