2011
Transcranial Two-Photon Imaging of the Living Mouse Brain
Grutzendler J, Yang G, Pan F, Parkhurst CN, Gan WB. Transcranial Two-Photon Imaging of the Living Mouse Brain. Cold Spring Harbor Protocols 2011, 2011: pdb.prot065474. PMID: 21880826, PMCID: PMC4641516, DOI: 10.1101/pdb.prot065474.Peer-Reviewed Original ResearchConceptsMouse brainAxonal varicositiesSurgical proceduresDendritic spinesSide effectsBrain cellsTwo-photon imagingInvasive methodBlood vesselsSame animalsPathological conditionsTwo-photon microscopyIntact skullBrainTranscranialImagingMicrogliaSurgeryVaricositiesImaging methodNeuronsLong time intervalsSpine
2007
Long-term two-photon transcranial imaging of synaptic structures in the living brain.
Grutzendler J, Gan WB. Long-term two-photon transcranial imaging of synaptic structures in the living brain. Cold Spring Harbor Protocols 2007, 2007: pdb.prot4766. PMID: 21357119, DOI: 10.1101/pdb.prot4766.Peer-Reviewed Original ResearchLiving brainNeurological disease modelsMouse brain areasIndividual dendritic spinesAxonal varicositiesFrontal cortexDendritic spinesBrain areasTherapeutic interventionsSynaptic structureFunctional changesNeuronal structuresTranscranial imagingTwo-photon microscopyDisease modelsBrainLiving mouseSensitive toolImaging approachMemory processesImagingSomatosensoryVaricositiesCortexMiceVarious Dendritic Abnormalities Are Associated with Fibrillar Amyloid Deposits in Alzheimer's Disease
GRUTZENDLER J, HELMIN K, TSAI J, GAN W. Various Dendritic Abnormalities Are Associated with Fibrillar Amyloid Deposits in Alzheimer's Disease. Annals Of The New York Academy Of Sciences 2007, 1097: 30-39. PMID: 17413007, DOI: 10.1196/annals.1379.003.Peer-Reviewed Original ResearchConceptsAmyloid depositsAlzheimer's diseasePSAPP miceFibrillar amyloid depositsAmyloid depositionDendritic abnormalitiesHuman AD tissueFibrillar amyloid depositionHuman AD brainsTransgenic mouse modelHuman postmortem brainDystrophic neuritesSpine lossAD brainAD tissueAmyloid plaquesCommon abnormalityMouse modelPostmortem brainsDendritic spinesNeuronal circuitsVaricosity formationSynaptic structureDiseaseDendritic branches
2006
Two-photon imaging of synaptic plasticity and pathology in the living mouse brain
Grutzendler J, Gan WB. Two-photon imaging of synaptic plasticity and pathology in the living mouse brain. Neurotherapeutics 2006, 3: 489-496. PMID: 17012063, PMCID: PMC3593400, DOI: 10.1016/j.nurx.2006.07.005.Peer-Reviewed Original ResearchConceptsTwo-photon microscopyMouse brainAcute brain injuryPostsynaptic dendritic spinesAdult mouse brainCerebral ischemiaSynaptic pathologyCerebrovascular diseaseBrain injuryMouse modelDendritic spinesAnimal modelsBrain cellsIntact brainTwo-photon imagingNeuronal connectionsSynaptic plasticityAlzheimer's diseaseNeuronal structuresDiseaseBrainStructural plasticityPathologyTechnical considerationsIschemia