1993
Inhibition of VIP-stimulated ion transport by a novel Y-receptor phenotype in rabbit distal colon
Ballantyne G, Goldenring J, Fleming F, Rush S, Flint J, Fielding L, Binder H, Modlin I. Inhibition of VIP-stimulated ion transport by a novel Y-receptor phenotype in rabbit distal colon. American Journal Of Physiology 1993, 264: g848-g854. PMID: 8388641, DOI: 10.1152/ajpgi.1993.264.5.g848.Peer-Reviewed Original ResearchConceptsVIP-stimulated increasesPeptide YYNeuropeptide YPancreatic polypeptideRabbit distal colonDistal colonRabbit distal colonic mucosaBasal short-circuit currentTetrodotoxin-insensitive mechanismVasoactive intestinal polypeptideDistal colonic mucosaColonic secretionIntestinal polypeptideReceptor phenotypeColonic mucosaParacrine regulatorVIP stimulationUssing chambersTissue cAMPPotent inhibitionCl fluxCyclic monophosphateColonInhibitionStimulation
1989
Regulation of active sodium and potassium transport in the distal colon of the rat. Role of the aldosterone and glucocorticoid receptors.
Turnamian S, Binder H. Regulation of active sodium and potassium transport in the distal colon of the rat. Role of the aldosterone and glucocorticoid receptors. Journal Of Clinical Investigation 1989, 84: 1924-1929. PMID: 2592566, PMCID: PMC304073, DOI: 10.1172/jci114380.Peer-Reviewed Original ResearchConceptsElectrogenic sodium absorptionReceptor-specific agonistsSodium absorptionAldosterone receptorsRU 28362Continuous infusionDistal colonGlucocorticoid receptorAmiloride-sensitive sodium absorptionColonic electrolyte transportEffects of aldosteroneRat distal colonPotassium transportActive sodiumPotassium secretionAldosteroneSustained increasePotassium absorptionAgonistsReceptorsElectrolyte transportGlucocorticoidsUnidirectional NaInfusionColon
1987
Mechanism of electroneutral sodium chloride absorption in distal colon of the rat
Binder H, Foster E, Budinger M, Hayslett J. Mechanism of electroneutral sodium chloride absorption in distal colon of the rat. Gastroenterology 1987, 93: 449-455. PMID: 3609655, DOI: 10.1016/0016-5085(87)90905-x.Peer-Reviewed Original ResearchConceptsSodium chloride absorptionElectroneutral sodium chloride absorptionNet sodium absorptionNet chloride absorptionDistal colonChloride absorptionSodium absorptionRat distal colonSodium chloride cotransportVoltage-clamp conditionsMM furosemideMM amilorideMucosal bathing solutionChloride transportClamp conditionsColonBathing solutionRatsElectrogenic sodiumMechanism of sodiumAmilorideSodiumAbsence of potassiumCotransportMucosa
1985
The electrical basis for enhanced potassium secretion in rat distal colon during dietary potassium loading
Sandle G, Foster E, Lewis S, Binder H, Hayslett J. The electrical basis for enhanced potassium secretion in rat distal colon during dietary potassium loading. Pflügers Archiv - European Journal Of Physiology 1985, 403: 433-439. PMID: 2409517, DOI: 10.1007/bf00589258.Peer-Reviewed Original ResearchConceptsRat distal colonDistal colonPotassium secretionDietary potassium loadingPotassium channel blocker tetraethylammonium chlorideBasolateral membrane voltageChannel blocker tetraethylammonium chloridePotassium loadingSodium channel blocker amilorideActive potassium secretionElectrical basisEnhanced potassium secretionChannel blocker amilorideMembrane conductanceIntracellular potassium activityApical membrane resistanceMucosal additionPotassium-selective microelectrodesBasal conditionsControl tissuesTransepithelial voltageColonMembrane voltageSecretionTetraethylammonium chloride
1984
Apical membrane properties and amiloride binding kinetics of the human descending colon
Wills N, Alles W, Sandle G, Binder H. Apical membrane properties and amiloride binding kinetics of the human descending colon. American Journal Of Physiology 1984, 247: g749-g757. PMID: 6095681, DOI: 10.1152/ajpgi.1984.247.6.g749.Peer-Reviewed Original Research