1988
Glucocorticoids have a different action than aldosterone on target tissue
Halevy J, Boulpaep E, Budinger M, Binder H, Hayslett J. Glucocorticoids have a different action than aldosterone on target tissue. American Journal Of Physiology 1988, 254: f153-f158. PMID: 3337244, DOI: 10.1152/ajprenal.1988.254.1.f153.Peer-Reviewed Original ResearchConceptsRU 28362Same doseInhibitory actionDexamethasone-treated animalsBody wt-1Effects of glucocorticoidsEffect of dexamethasoneReceptor-independent actionsRat distal colonSodium channel blockersMarked inhibitory actionEquivalent short-circuit currentBasolateral potential differenceAldosterone receptorsEpithelial changesDistal colonChannel blockersAldosteroneSynthetic glucocorticoidDay 1WT-1Large intestineGlucocorticoidsEpithelial resistanceMarked inhibition
1985
Role of Aldosterone and Dietary Potassium in Potassium Adaptation in the Distal Colon of the Rat
Foster E, Jones W, Hayslett J, Binder H. Role of Aldosterone and Dietary Potassium in Potassium Adaptation in the Distal Colon of the Rat. Gastroenterology 1985, 88: 41-46. PMID: 3964771, DOI: 10.1016/s0016-5085(85)80130-x.Peer-Reviewed Original ResearchConceptsPotassium-enriched dietChronic potassium loadingNet potassium secretionAldosterone levelsDietary potassiumPotassium adaptationNet potassium transportPotassium secretionAldosterone-independent mechanismsBasal aldosterone levelsPotassium-loaded animalsRole of aldosteronePotassium loadingInfusion of aldosteroneDistal colonic mucosaEffects of aldosteroneIntact adrenal glandsNet potassium absorptionPotassium transportAdrenal glandDistal colonColonic mucosaIntact ratsAdrenalectomized animalsExperimental rats