1999
Bacterial translocation in cirrhotic rats stimulates eNOS-derived NO production and impairs mesenteric vascular contractility
Wiest R, Das S, Cadelina G, Garcia-Tsao G, Milstien S, Groszmann R. Bacterial translocation in cirrhotic rats stimulates eNOS-derived NO production and impairs mesenteric vascular contractility. Journal Of Clinical Investigation 1999, 104: 1223-1233. PMID: 10545521, PMCID: PMC409820, DOI: 10.1172/jci7458.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBacterial TranslocationDose-Response Relationship, DrugLiver Cirrhosis, ExperimentalLymph NodesMaleMesenteric ArteriesMethoxamineNitric OxideNitric Oxide SynthasePerfusionPressureProtein IsoformsRatsRats, Sprague-DawleyStress, MechanicalTumor Necrosis Factor-alphaVasoconstrictionVasoconstrictor AgentsConceptsMesenteric lymph nodesEndothelial NO synthaseTNF-alpha productionAscitic cirrhotic ratsBacterial translocationCirrhotic ratsMesenteric vasculatureNitric oxidePresence of BTSuperior mesenteric arterial bedMesenteric arterial bedNitro-L-arginineTNF-alpha synthesisVascular hyporesponsivenessArterial vasodilationLiver cirrhosisLymph nodesVascular contractilityVascular responsesTNF-alphaArterial bedNO inhibitorNOS activityNO overproductionNO synthase
1995
Bacterial translocation to mesenteric lymph nodes is increased in cirrhotic rats with ascites
Garcia-Tsao G, Lee F, Barden G, Cartun R, West A. Bacterial translocation to mesenteric lymph nodes is increased in cirrhotic rats with ascites. Gastroenterology 1995, 108: 1835-1841. PMID: 7768390, DOI: 10.1016/0016-5085(95)90147-7.Peer-Reviewed Original ResearchConceptsMesenteric lymph nodesLymph nodesBacterial translocationCirrhotic ratsPositive mesenteric lymphRegional lymph nodesDevelopment of ascitesE. coli translocationStandard bacteriologic cultureCCl4 inhalationSpontaneous bacteremiaCirrhotic patientsMesenteric lymphSubmucosal edemaPassage of bacteriaRat modelBACKGROUND/Systemic circulationAscitesCecal wallNormal controlsIntestinal lumenCirrhosisSpontaneous infectionBacteriologic culture
1993
Bacterial translocation in acute and chronic portal hypertension
Garcia‐Tsao G, Albillos A, Barden G, West A. Bacterial translocation in acute and chronic portal hypertension. Hepatology 1993, 17: 1081-1085. PMID: 8514258, DOI: 10.1002/hep.1840170622.Peer-Reviewed Original ResearchConceptsChronic portal hypertensionPortal hypertensionAcute portal hypertensionBacterial translocationLymph nodesPartial portal vein ligationExperimental portal hypertensionPositive mesenteric lymphMesenteric lymph nodesPortal vein ligationRegional lymph nodesSham-operated controlsFragments of ileumMesenteric inflammationSpontaneous bacteremiaChronic ratsVein ligationControl surgeryMesenteric lymphBowel wallPassage of bacteriaHypertensionHistological examinationSystemic circulationControl animals