2023
WED-352 Gender differences in the patient-reported outcomes and perception of ascites burden amongst outpatients with decompensated cirrhosis and ascites
Wong F, Reddy K, Tandon P, Lai J, Garcia-Tsao G, O’Leary J, Biggins S, Vargas H, Thacker L, Bajaj J. WED-352 Gender differences in the patient-reported outcomes and perception of ascites burden amongst outpatients with decompensated cirrhosis and ascites. Journal Of Hepatology 2023, 78: s256. DOI: 10.1016/s0168-8278(23)00822-x.Peer-Reviewed Original Research
2021
SACRED: Effect of simvastatin on hepatic decompensation and death in subjects with high-risk compensated cirrhosis: Statins and Cirrhosis: Reducing Events of Decompensation
Kaplan D, Mehta R, Garcia-Tsao G, Albrecht J, Aytaman A, Baffy G, Bajaj J, Hernaez R, Hunt K, Ioannou G, Johnson K, Kanwal F, Lee T, Monto A, Pandya P, Schaubel D, Taddei T. SACRED: Effect of simvastatin on hepatic decompensation and death in subjects with high-risk compensated cirrhosis: Statins and Cirrhosis: Reducing Events of Decompensation. Contemporary Clinical Trials 2021, 104: 106367. PMID: 33771685, PMCID: PMC8422958, DOI: 10.1016/j.cct.2021.106367.Peer-Reviewed Original ResearchConceptsHepatic decompensationPortal hypertensionEvents of decompensationHepatic decompensation eventsLiver-related deathSignificant portal hypertensionAcceptable safety profileProspective human studiesRole of statinsChronic liver diseaseClasses of medicationsPatient-reported outcomesDevelopment of decompensationEffect of simvastatinVA Medical CenterCompensated cirrhosisDecompensation eventsStatin therapyVariceal hemorrhageCirrhotic patientsStandard therapyVascular reactivityExert pleiotropic effectsLiver diseaseRetrospective study
2020
Factors associated with health‐related quality of life in patients with cirrhosis: a systematic review
Rabiee A, Ximenes R, Nikayin S, Hickner A, Juthani P, Rosen RH, Garcia‐Tsao G. Factors associated with health‐related quality of life in patients with cirrhosis: a systematic review. Liver International 2020, 41: 6-15. PMID: 32998172, DOI: 10.1111/liv.14680.Peer-Reviewed Original ResearchConceptsHealth-related qualityPoor HRQOLMuscle crampsHepatic encephalopathyPoor sleepSystematic reviewPoor health-related qualityPatient-reported outcomesPoor social supportPatient-centered careFull-text screeningAdult patientsPoor HRQoL.Cirrhosis etiologyHRQoLCirrhosisGeneric instrumentsEligibility criteriaCognitive impairmentPatientsMajority of studiesIdentified factorsCrampsDemographic factorsFrailty