2022
Association of serum metabolites and gut microbiota at hospital admission with nosocomial infection development in patients with cirrhosis
Bajaj JS, Reddy KR, Tandon P, Garcia‐Tsao G, Kamath PS, O'Leary JG, Wong F, Lai J, Vargas H, Thuluvath PJ, Subramanian RM, Pena‐Rodriguez M, Sikaroodi M, Thacker LR, Gillevet PM. Association of serum metabolites and gut microbiota at hospital admission with nosocomial infection development in patients with cirrhosis. Liver Transplantation 2022, 28: 1831-1840. PMID: 36017804, PMCID: PMC11097235, DOI: 10.1002/lt.26552.Peer-Reviewed Original ResearchConceptsNosocomial infectionsGut microbiotaAnalysis of covariancePoor outcomeClinical variablesSerum metabolitesCommensal microbiotaNI developmentIntensive care unit transferHigh MELD scoreLiquid chromatography-mass spectrometry metabolomicsSpontaneous bacterial peritonitisCommon nosocomial infectionAdmission WBCHospital courseInpatient outcomesMELD scoreBacterial peritonitisHospital admissionOrgan failureStool microbiotaSerum metabolomicsStool samplesCirrhosisPatientsTHU494 Serum metabolites on admission associate with the development of nosocomial infections in inpatients with cirrhosis
Bajaj J, O’Leary J, Tandon P, Garcia-Tsao G, Kamath P, Thuluvath P, Subramanian R, Vargas H, McGeorge S, Fagan A, Wong F, Lai J, Thacker L, Reddy R. THU494 Serum metabolites on admission associate with the development of nosocomial infections in inpatients with cirrhosis. Journal Of Hepatology 2022, 77: s339-s340. DOI: 10.1016/s0168-8278(22)01041-8.Peer-Reviewed Original Research82: SERUM METABOLITES ON ADMISSION ASSOCIATE WITH OCCURRENCE OF NOSOCOMIAL INFECTIONS IN HOSPITALIZED PATIENTS WITH CIRRHOSIS
Bajaj J, O'Leary J, Tandon P, Garcia-Tsao G, Kamath P, Thuluvath P, Subramanian R, Lai J, Vargas H, Mcgeorge S, Fagan A, Wong F, Thacker L, Reddy K. 82: SERUM METABOLITES ON ADMISSION ASSOCIATE WITH OCCURRENCE OF NOSOCOMIAL INFECTIONS IN HOSPITALIZED PATIENTS WITH CIRRHOSIS. Gastroenterology 2022, 162: s-1114. DOI: 10.1016/s0016-5085(22)62677-5.Peer-Reviewed Original Research
2016
The 3‐month readmission rate remains unacceptably high in a large North American cohort of patients with cirrhosis
Bajaj JS, Reddy KR, Tandon P, Wong F, Kamath PS, Garcia‐Tsao G, Maliakkal B, Biggins SW, Thuluvath PJ, Fallon MB, Subramanian RM, Vargas H, Thacker LR, O'Leary JG, Disease N. The 3‐month readmission rate remains unacceptably high in a large North American cohort of patients with cirrhosis. Hepatology 2016, 64: 200-208. PMID: 26690389, PMCID: PMC4700508, DOI: 10.1002/hep.28414.Peer-Reviewed Original ResearchConceptsEnd-stage liver diseaseNosocomial infectionsLiver diseaseEnd-stage Liver Disease cohortEnd-stage liver disease (MELD) scoreSmall single-center studiesLarge North American cohortHigher readmission riskInfection-related readmissionLiver disease cohortPercent of readmissionsLiver Disease scoreSingle-center studyMultivariable logistic regressionNorth American cohortNorth American ConsortiumIndex admissionNonelective indicationsAdvanced cirrhosisProphylactic antibioticsCirrhosis severityInhibitor useReadmission ratesMonths postdischargeReadmission risk
2012
High Prevalence of Antibiotic-Resistant Bacterial Infections Among Patients With Cirrhosis at a US Liver Center
Tandon P, DeLisle A, Topal JE, Garcia–Tsao G. High Prevalence of Antibiotic-Resistant Bacterial Infections Among Patients With Cirrhosis at a US Liver Center. Clinical Gastroenterology And Hepatology 2012, 10: 1291-1298. PMID: 22902776, PMCID: PMC3891826, DOI: 10.1016/j.cgh.2012.08.017.Peer-Reviewed Original ResearchConceptsSystemic antibioticsBacterial infectionsAntibiotic-resistant bacterial infectionsOdds ratioTertiary care transplant centerCulture-positive infectionsSpontaneous bacterial peritonitisUrinary tract infectionMultivariate logistic regressionPercent of infectionsFirst bacterial infectionInfectious episodesLiver centersLiver unitTract infectionsBacterial peritonitisTransplant centersRisk factorsHigh prevalenceNosocomial infectionsPatientsUS hospitalsCirrhosisAbstractTextInfection