2021
Significant Liver Injury During Hospitalization for COVID-19 Is Not Associated With Liver Insufficiency or Death
Chew M, Tang Z, Radcliffe C, Caruana D, Doilicho N, Ciarleglio MM, Deng Y, Garcia-Tsao G. Significant Liver Injury During Hospitalization for COVID-19 Is Not Associated With Liver Insufficiency or Death. Clinical Gastroenterology And Hepatology 2021, 19: 2182-2191.e7. PMID: 34004326, PMCID: PMC8123528, DOI: 10.1016/j.cgh.2021.05.022.Peer-Reviewed Original ResearchConceptsSignificant liver injuryLiver injuryLiver insufficiencyCOVID-19High-sensitivity C-reactive protein valuesC-reactive protein valuesDrug-induced liver injuryHepatocellular liver injuryInternational normalized ratioMultivariate logistic regressionHyperinflammatory stateTocilizumab useVasopressor useConcomitant medicationsConsecutive patientsIndependent predictorsLiver failureBilirubin levelsD-dimerTest abnormalitiesNormalized ratioAlanine aminotransferaseHospitalizationPatientsInjury
2019
Emricasan (IDN‐6556) Lowers Portal Pressure in Patients With Compensated Cirrhosis and Severe Portal Hypertension
Garcia‐Tsao G, Fuchs M, Shiffman M, Borg BB, Pyrsopoulos N, Shetty K, Gallegos‐Orozco J, Reddy KR, Feyssa E, Chan JL, Yamashita M, Robinson JM, Spada AP, Hagerty DT, Bosch J. Emricasan (IDN‐6556) Lowers Portal Pressure in Patients With Compensated Cirrhosis and Severe Portal Hypertension. Hepatology 2019, 69: 717-728. PMID: 30063802, PMCID: PMC6587783, DOI: 10.1002/hep.30199.Peer-Reviewed Original ResearchConceptsSevere portal hypertensionPortal hypertensionAlanine aminotransferaseCompensated cirrhosisEnd-stage liver disease (MELD) scoreAspartate aminotransferaseAST/alanine aminotransferaseChild class ALiver Disease scoreOpen-label studyNonserious adverse eventsPortal venous inflowAnti-inflammatory effectsHepatitis C virusSplanchnic vasodilationAdverse eventsHVPG measurementIntrahepatic inflammationPortal pressureBlood pressureCirrhosis etiologyMedian ageNonalcoholic steatohepatitisVenous inflowSignificant changes