2024
Innate Immune Mechanisms Associated With Exacerbations on Mepolizumab
Wilson G, Liu Q, Gautam S, Knight J, Shelar A, Stewart E, Visness C, Sanders J, Gill M, Gruchalla R, Liu A, Kattan M, Khurana Hershey G, Togias A, Becker P, Altman M, Busse W, Jackson D, Montgomery R, Chupp G. Innate Immune Mechanisms Associated With Exacerbations on Mepolizumab. 2024, a6984-a6984. DOI: 10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a6984.Peer-Reviewed Original ResearchActivated sputum eosinophils associated with exacerbations in children on mepolizumab
Wilson G, Knight J, Liu Q, Shelar A, Stewart E, Wang X, Yan X, Sanders J, Visness C, Gill M, Gruchalla R, Liu A, Kattan M, Khurana Hershey G, Togias A, Becker P, Altman M, Busse W, Jackson D, Montgomery R, Chupp G. Activated sputum eosinophils associated with exacerbations in children on mepolizumab. Journal Of Allergy And Clinical Immunology 2024, 154: 297-307.e13. PMID: 38485057, PMCID: PMC11305967, DOI: 10.1016/j.jaci.2024.01.031.Peer-Reviewed Original ResearchAirway eosinophilsSputum eosinophilsPatients treated with mepolizumabPlacebo-controlled clinical trialAnti-IL-5 treatmentEffect of mepolizumabEosinophil subpopulationsSevere eosinophilic asthmaAnti-interleukin-5Expression of CD62LFrequency of exacerbationsEosinophilic asthmaActivation markersSputum samplesUnsupervised cluster analysisMepolizumabTreatment armsReduce exacerbationsCD62LClinical trialsExacerbationMass cytometryEosinophilsExacerbation riskIntracellular markers
2023
Functional Analysis of Sputum Eosinophil Subpopulations in Children With Asthma
Wilson G, Liu Q, Knight J, Shelar A, Stewart E, Visness C, Sanders J, Gill M, Gruchalla R, Liu A, Kattan M, Hershey G, Togias A, Becker P, Altman M, Busse W, Jackson D, Montgomery R, Chupp G. Functional Analysis of Sputum Eosinophil Subpopulations in Children With Asthma. 2023, a3016-a3016. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a3016.Peer-Reviewed Original Research
2022
Exploring the Effect of Anti-IL5 Therapy on Sputum Eosinophils in Children with Asthma
Wilson G, Liu Q, Knight J, Visness C, Villarreal M, Gill M, Gruchalla R, Liu A, Kattan M, Hershey G, Togias A, Becker P, Altman M, Busse W, Jackson D, Montgomery R, Chupp G. Exploring the Effect of Anti-IL5 Therapy on Sputum Eosinophils in Children with Asthma. 2022, a4833-a4833. DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a4833.Peer-Reviewed Original Research
2019
Analysis of Sputum Immune Cell Populations and Their Functional Status in Asthmatics
Stewart E, Chupp G, Montgomery R, Liu Q, Estrom J. Analysis of Sputum Immune Cell Populations and Their Functional Status in Asthmatics. 2019, a2916-a2916. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a2916.Peer-Reviewed Original Research
2017
Multiparameter Single Cell Profiling of Airway Inflammatory Cells
Yao Y, Welp T, Liu Q, Niu N, Wang X, Britto CJ, Krishnaswamy S, Chupp G, Montgomery RR. Multiparameter Single Cell Profiling of Airway Inflammatory Cells. Cytometry Part B Clinical Cytometry 2017, 92: 12-20. PMID: 27807928, PMCID: PMC5250532, DOI: 10.1002/cyto.b.21491.Peer-Reviewed Original ResearchConceptsSingle-cell methodsComplex trait diseasesSubgroup of asthmaticsSingle-cell analysisMultiparameter single cell analysisMillions of patientsTranscriptional analysisImmunologic underpinningsInduced sputumAirway diseaseAsthmatic patientsAirway samplesCell subsetsImmune statusFunctional statusClinical severityDistinct biologic mechanismsTreatment successPhysiologic manifestationsBiologic mechanismsCystic fibrosisCellular analysisPatientsCytometry studiesU.S. population