2009
The chitinase and chitinase-like proteins: a review of genetic and functional studies in asthma and immune-mediated diseases
Ober C, Chupp GL. The chitinase and chitinase-like proteins: a review of genetic and functional studies in asthma and immune-mediated diseases. Current Opinion In Allergy And Clinical Immunology 2009, 9: 401-408. PMID: 19644363, PMCID: PMC3018778, DOI: 10.1097/aci.0b013e3283306533.Peer-Reviewed Original ResearchConceptsChitinase-like proteinsNovel asthma susceptibility genesAsthma susceptibility genesRegulatory SNPsNonsynonymous SNPsNonfunctional allelesDiverse ancestryGenetic studiesChitinase activityGenesSusceptibility genesFunctional studiesChitinaseDuplication alleleMammalian chitinaseProteinMajor chitinaseEnzyme activityPolymorphismSNPsChiaAllelesCHIT1CHI3L1Present review
2008
Effect of Variation in CHI3L1 on Serum YKL-40 Level, Risk of Asthma, and Lung Function
Ober C, Tan Z, Sun Y, Possick JD, Pan L, Nicolae R, Radford S, Parry RR, Heinzmann A, Deichmann KA, Lester LA, Gern JE, Lemanske RF, Nicolae DL, Elias JA, Chupp GL. Effect of Variation in CHI3L1 on Serum YKL-40 Level, Risk of Asthma, and Lung Function. New England Journal Of Medicine 2008, 358: 1682-1691. PMID: 18403759, PMCID: PMC2629486, DOI: 10.1056/nejmoa0708801.Peer-Reviewed Original ResearchMeSH KeywordsAdipokinesAdolescentAdultAgedAged, 80 and overAsthmaBiomarkersBronchial HyperreactivityCase-Control StudiesChildChitinase-3-Like Protein 1FemaleFounder EffectGenetic Predisposition to DiseaseGenotypeGlycoproteinsHumansLectinsMaleMiddle AgedPhenotypePolymorphism, Single NucleotidePulmonary VentilationConceptsSerum YKL-40 levelsYKL-40 levelsLung functionYears of ageBronchial hyperresponsivenessPulmonary functionSingle nucleotide polymorphismsYKL-40Elevated serum YKL-40 levelsBirth cohortChitinase-like protein YKL-40Presence of asthmaProtein YKL-40Risk of asthmaPromoter single nucleotide polymorphismsEuropean descentSubepithelial basement membraneCase-control populationCase patientsAsthma statusAsthmaHigh riskChitinase 3Same single nucleotide polymorphismCHI3L1