2012
Administration of Vincristine in a Patient with Machado-Joseph Disease
Colpo A, Wilson FH, Nardi V, Hochberg E. Administration of Vincristine in a Patient with Machado-Joseph Disease. Oncology 2012, 82: 165-167. PMID: 22433430, PMCID: PMC3701890, DOI: 10.1159/000336602.Peer-Reviewed Original ResearchConceptsMachado-Joseph diseaseChemotherapy-induced peripheral neurotoxicityDose-limiting side effectVinca alkaloidsSevere vincristine neurotoxicityAdministration of vincristinePeripheral neurotoxicitySpinocerebellar ataxia type 3Vincristine neurotoxicityNeurological symptomsAtaxia type 3Side effectsHereditary neuropathyAntineoplastic drugsType 3NeurotoxicityDiseaseSignificant numberNeuropathyExacerbationPatientsVincristineSymptomsAdministration
2006
WNK3, a kinase related to genes mutated in hereditary hypertension with hyperkalaemia, regulates the K+ channel ROMK1 (Kir1.1)
Leng Q, Kahle KT, Rinehart J, MacGregor GG, Wilson FH, Canessa CM, Lifton RP, Hebert SC. WNK3, a kinase related to genes mutated in hereditary hypertension with hyperkalaemia, regulates the K+ channel ROMK1 (Kir1.1). The Journal Of Physiology 2006, 571: 275-286. PMID: 16357011, PMCID: PMC1796803, DOI: 10.1113/jphysiol.2005.102202.Peer-Reviewed Original ResearchConceptsDistal convoluted tubuleInhibition of ROMK1KCNQ1/KCNE1Renal NaCl reabsorptionEpithelial sodium channelAmiloride-sensitive currentDistal nephronVivo effectsConvoluted tubulesKinase-dependent activationQT syndromeNCC activityNaCl reabsorptionNephron segmentsDuct principal cellsHereditary hypertensionSodium channelsPrincipal cellsII cellsRenal NaClSurface expressionXenopus laevis oocytesHypertensionHomeostatic systemDisease
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