2025
MAT2A inhibitor AG-270/S095033 in patients with advanced malignancies: a phase I trial
Gounder M, Johnson M, Heist R, Shapiro G, Postel-Vinay S, Wilson F, Garralda E, Wulf G, Almon C, Nabhan S, Aguado-Fraile E, He P, Romagnoli M, Hossain M, Narayanaswamy R, Sadou-Dubourgnoux A, Cooper M, Askoxylakis V, Burris H, Tabernero J. MAT2A inhibitor AG-270/S095033 in patients with advanced malignancies: a phase I trial. Nature Communications 2025, 16: 423. PMID: 39762248, PMCID: PMC11704051, DOI: 10.1038/s41467-024-55316-5.Peer-Reviewed Original ResearchConceptsAdvanced malignanciesEvidence of clinical activityPaired tumor biopsiesTreatment-related toxicityPhase I trialPhase 1 trialFirst-in-humanLiver function testsProof-of-mechanismHomozygous MTAP deletionPlasma SAM concentrationsPartial responseConcentrations of S-adenosylmethionineTumor biopsiesI trialSafety profileMTAP deletionHomozygous deletionMAT2A inhibitionClinical activityPlasma concentrationsFunction testsPatientsSecondary objectivesMaximal reduction
2021
Osimertinib in EGFR-Mutant Non-Small Cell Lung Carcinoma: Clinical Activity and Mechanisms of Resistance
Talsania A, Zhang J, Wilson F. Osimertinib in EGFR-Mutant Non-Small Cell Lung Carcinoma: Clinical Activity and Mechanisms of Resistance. Current Cancer Research 2021, 65-73. DOI: 10.1007/978-3-030-74028-3_4.ChaptersNon-small cell lung carcinomaEGFR-mutant non-small cell lung carcinomaEpidermal growth factor receptorCell lung carcinomaLung carcinomaSmall cell lung carcinomaEGFR-Mutant NonMajor therapeutic challengeCare of patientsPotential therapeutic strategyConstitutive EGFR activationThird-generation EGFR inhibitorsUpregulation of pathwaysGrowth factor receptorResistance mechanismsAdjuvant settingTherapeutic challengeMechanisms of resistanceClinical activityTherapeutic strategiesClinical developmentSmall molecule inhibitorsEGFR inhibitorsFactor receptorEGFR activation
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