2012
The natural history of hormone receptor-positive breast cancer.
Lim E, Metzger-Filho O, Winer EP. The natural history of hormone receptor-positive breast cancer. Oncology 2012, 26: 688-94, 696. PMID: 22957400.Peer-Reviewed Original ResearchConceptsBreast cancerEstrogen receptorLate relapseProgesterone receptorHormone receptor-positive breast cancerAdjuvant anti-estrogen therapyHR-positive breast cancerReceptor-positive breast cancerNatural historyHormone receptorsAnti-estrogen therapyLong natural historyPredictors of responseBreast cancer subtypesHuman breast tumorsSignificant clinical challengePatient tumor samplesTranslational research strategiesCurrent clinical strategiesAntiestrogen therapyRelapse patternsPreclinical modelsClinical challengeTreatment resistanceTumor relapse
2007
Brain Metastases: The HER2 Paradigm
Lin NU, Winer EP. Brain Metastases: The HER2 Paradigm. Clinical Cancer Research 2007, 13: 1648-1655. PMID: 17363517, DOI: 10.1158/1078-0432.ccr-06-2478.Peer-Reviewed Original ResearchConceptsHER2-positive breast cancerCNS diseaseBreast cancerCentral nervous system metastasesExtra-CNS diseaseImportant sanctuary siteNervous system metastasesProportion of patientsTerms of prognosisCNS metastasesCNS progressionBrain metastasesCytotoxic chemotherapySystemic therapyAdvanced cancerTherapeutic challengePrimary diagnosisHistorical controlsTargeted therapyPreventive strategiesSanctuary siteTumor subtypesParticular tumor subtypesPatientsNatural history